Publication: Acute effect of hemodialysis on arterial elasticity
Date
2015-01-01
Authors
Sağ, Saim
Yeşilbursa, Dilek
Yıldız, Abdülmecit
Dilek, Kamil
Şentürk, Tunay
Serdar, Osman Akın
Aydınlar, Ali
Journal Title
Journal ISSN
Volume Title
Publisher
TÜBİTAK
Abstract
Background/aim: Reduced arterial elasticity is an independent predictor of cardiovascular mortality in patients with end-stage renal disease (ESRD). Hemodialysis (HD) treatment per se can bring additional risk factors for vascular disease. Our study was designed to determine whether a single hemodialysis session leads to an acute alteration in parameters of arterial elasticity in ESRD.Materials and methods: In this study, 58 patients undergoing chronic hemodialysis and 29 healthy controls were enrolled. Large artery elasticity index (LAEI) and the small artery elasticity index (SAEI) were measured by applanation tonometry. The acute effect of a hemodialysis session on arterial elasticity indices was assessed by comparison of prehemodialysis and posthemodialysis determinations.Results: At baseline, LAEI did not differ significantly in patients compared with controls. In contrast, the SAEI was significantly lower in patients (4.1 +/- 2.6 mL/mmHg x 100) than in healthy individuals (8.9 +/- 3.4 mL/mmHg x 100, P < 0.05). In patients with ESRD, no significant changes in LAEI was observed after HD, but SAEI deteriorated significantly (from 4.1 +/- 2.6 mL/mmHg x 100 to 3.4 +/- 2.3, P < 0.05).Conclusion: We conclude that ESRD patients face a significant reduction in SAEI, which is exacerbated by a dialysis procedure.
Description
Keywords
Cardiovascular-disease, Endothelial function, Stiffness, Predicts, Therapy, Death, Arterial elasticity, Hemodialysis, Applanation tonometry, General & internal medicine