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Recent Submissions
Serological screening for celiac disease and gastrointestinal absorption disorders in patients with autoimmune endocrine diseases
(Georg Thieme Verlag Kg, 2023-10-05) Kocaeli, Ayşen Akkurt; Cander, Soner; Gül, Özen Öz; Şişman, Pınar; Ersoy, Canan; Ertürk, Erdinç; CANDER, SONER; ÖZ GÜL, ÖZEN; ERSOY, CANAN; ERTÜRK, ERDİNÇ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Anabilim Dalı.; CJH-1319-2022; JML-9116-2023; AAH-8861-2021; JME-6802-2023
Celiac disease (CD) accompanying autoimmune endocrine diseases (AED) is generally asymptomatic. This study aimed to evaluate the frequency of clinically overt or silent CD in patients diagnosed with autoimmune endocrinopathy and the clinical effects of silent CD in these endocrinopathies. The study included 166 patients with known or newly diagnosed mono-/polyglandular AED and 90 age- and gender-matched healthy controls. The patients were classified into four groups: type 1 diabetes mellitus (DM) (n=44), Hashimoto's thyroiditis (HT) (n=68), Addison's disease (AD) (n=17), and autoimmune polyglandular syndrome (APS) (n=37). All subjects were serologically screened for tissue transglutaminase antibody (tTG) IgA and IgG. In addition, to evaluate the possible systemic consequences of CD, serum parathormone (PTH), 25-hydroxicholecalsiferol (25-OH-Vit D), vitamin B12, folic acid, iron, iron-binding capacity (IBC), and ferritin levels were measured. In the total series, 193 (75.4%) individuals were females, and 63 (24.6%) were males. TTG IgA antibody positivity was found in 23 among 166 patients, while no positivity was encountered in the healthy control group. The highest rates of positive tTg IgA frequency were detected in AD, with 29.4% (5/17). Serum 25-OH-Vit D, vitamin B12, folic acid, iron, and ferritin levels were significantly lower in AEDs compared to controls (p<0.001), and the lowest these parameters were detected in patients with AD. The serologic CD prevalence is higher in autoimmune mono-/and polyglandular endocrine diseases than in the control group. The data support recommends regular screening for CD in all patients with AEDs.
The interrelationship between FYN and miR-128/193a-5p/494 in imatinib resistance in prostate cancer
(Bentham Science Publ Ltd, 2023-01-01) Ergün, Sercan; Akgün, Oğuzhan; Hekim, Neslihan Taşkurt; Aslan, Senanur; Arı, Ferda; Güneş, Sezgin; Abur, Ümmet; Akgün, Oğuzhan; ARI, FERDA; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Moleküler Biyoloji Bölümü.; 0000-0002-8410-1786; 0000-0002-6729-7908; A-5608-2019; AAG-7012-2021
Background: C-KIT is a receptor tyrosine kinase with oncogenic properties overexpressed in PCa cases. Through the use of an alternative promoter, a truncated c-KIT protein (tr-KIT) of 30-50 kDa is generated, lacking the extracellular and transmembrane domain. Tr-KIT promotes the formation of a multi-molecular complex composed of Fyn, Plc gamma 1, and Sam68. Imatinib blocks the activity of full-length c-KIT but has no effect on tr-KIT. LNCaP is the human PCa cell line that shows tr-KIT overexpression and PC3 does not show tr-KIT overexpression. miR-128/193a-5p/494 are miRNAs targeting FYN, PLC gamma 1, and SAM68 combinatorially. The study's question is: can miR-128/193a-5p/494 be related to imatinib resistance in PCa?Methods: LNCaP and PC3 cells were treated with imatinib in IC50 doses. Before and after imatinib administration, RNA was isolated and cDNA conversion was performed. By qPCR analysis, expression changes of tr-KIT specific pathway elements and miR-128/193a-5p/494 were analyzed before and after imatinib administration.Results: After imatinib administration, miR-128/193a-5p/494 were significantly overexpressed in LNCaP cells while downregulated significantly in PC3 cells (p<0.05). Also, FYN was upregulated in LNCaP cells (p<0.05) but there was no change in PC3 after imatinib administration.Conclusion: Especially upregulation of FYN may sponge miR128/193a-5p/494 and downregulate their transcriptional activity in LNCaP cells having tr-KIT activity. So, miR-128/193a-5p/494 may have a critical role in imatinib resistance via a tr-KIT pathway.
Evaluation of diagnosis and treatment results in children with graves' disease with emphasis on the pubertal status of patients
(Freund Publishing House Ltd, 2008-08-01) Poyrazoğlu, Sükran; Saka, Nurcin; Baş, Firdevs; İşgüven, Pınar; Doğu, Ayşegül; Turan, Serap; Turan, Abdullah; Sarıkaya, Sevil; Adal, Erdal; Çizmeci, Filiz; Sağlam, Halil; Ercan, Oya; Memioğlu, Nihal; Guenoz, Hülya; Bundak, Ruveyde; Darendeliler, Feyza; Yıldız, Metin; Güran, Tülay; Akçay, Teoman; Akın, Leyla; Hatun, Şükrü; SAĞLAM, HALİL; Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-0710-5422 ; C-7392-2019
This retrospective study evaluated the clinical and laboratory characteristics at presentation and treatment results of patients with Graves' disease (GD) with respect to pubertal status. Records of 143 patients (108 F, 35 M) were reviewed in a multicenter study. At diagnosis., 38% of patients were prepubertal. Anti-thyroid drugs (ATD) were used as initial therapy. There was no significant difference in clinical and laboratory characteristics at diagnosis, during treatment and adverse reaction to ATD with respect to pubertal status. Twenty patients (7 prepubertal, 13 pubertal) reached remission on ATD. Surgery was performed in seven and radioiodine (RAI) in four patients. Duration of treatment needed to achieve remission was longer in prepubertal (4.2 +/- 1.0 yr) than in pubertal patients (3.1 +/- 1.3 yr) (p = 0.02). The rate of remission was not different between prepubertal (25.9%) and pubertal patients (33.3%) (p = 0.59). ATD were associated with low remission rate in pediatric GD and required longer duration of therapy in prepubertal patients. For definitive treatment in older children, RAI could be evaluated as the initial therapy.
Reevaluation of the electroencephalogram recordings of patients with nonconvulsive status epilepticus by using salzburg consensus criteria
(Wolters Kluwer Medknow Publications, 2022-04-01) Timer, Emin; Yilgor, Abdullah; Bebek, Nerses; Baykan, Betül; Oğuz-Akarsu, Emel; OĞUZ AKARSU, EMEL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; IZQ-0662-2023
Objective: Nonconvulsive status epilepticus (NCSE) is a challenge to diagnose in some cases, and recently, Salzburg consensus criteria for NCSE (SCC-NCSE) were developed to contribute to clinical practice. We aimed to investigate their validity and usefulness by reevaluating the electroencephalogram (EEG) examinations of our patients in this study. Materials and Methods: We retrospectively evaluated all EEG recordings of patients diagnosed with NCSE by experienced clinical neurophysiologists in our EEG laboratory over a period of 2 years. Two neurologists trained in EEG reanalyzed all EEG data and categorized these patients as NCSE, possible NCSE, or non-NCSE using the SCC-NCSE. Results: Twenty-nine patients with a mean age of 31.5 & PLUSMN; 25.9 were reanalyzed. According to the SCC-NCSE, 24 patients (82.7%) were diagnosed as NCSE. Eighteen patients (62%) who fulfilled all SCC-NCSE were diagnosed as NCSE, whereas six patients (20.7%) were diagnosed only as possible NCSE. Five patients (17.3%) did not fulfill SCC-NCSE; the reasons are the lack of additional secondary criteria in 2 patients with encephalopathy, the absence of full compliance with the criteria in other 2 patients, and a diagnosis of electrical status epilepticus during sleep in the last patient. Conclusion: The results of our study show that SCC-NCSE is highly consistent with clinical practice to decide for the diagnosis of NCSE. The evaluation of NCSE according to a set of new standardized criteria is thought to be difficult in practice, but it provides a more objective assessment. Therefore, we believe that its use should be encouraged to increase experience and the possibility of correct diagnosis.
Use of posaconazole for pulmonary mucormycosis in persistent febrile neutropenia: A case report
(Aves, 2011-04-01) Erbay-Apaydin, Fatma; Orhan, Bulent; Bilgi, Selçuk; Akalın, Halis; AKALIN, EMİN HALİS; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.; 0000-0001-7530-1279; AAU-8952-2020
Pulmonary mucormycosis is an opportunist fungal infection with high mortality. Posaconazole, an azole antifungal which has a proven efficacy against zygomycetes in vitro, has been shown to be useful as salvage therapy in various studies. We reported herein a lymphoma patient with persistent febrile neutropenia treated for invasive aspergillosis who developed pulmonary mucormycosis subsequently, and shared our experience on his treatment using posaconazole as salvage therapy following amphothericin B, which is thought to enhance survival because of the positive outcome achieved.
