Person: SERDAR, OSMAN AKIN
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SERDAR
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OSMAN AKIN
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Publication Coronary risk factors and coronary angiography results of 12.257 patients(Elsevier, 2013-10-29) Günay, Şeyda; Serdar, Osman Akın; Özyılmaz, Sinem Özbay; Dereli, Seçkin; Aydınlar, Ali; Baran, İbrahim; Özdemir, Bülent; Yeşilbursa, Dilek; Güllülü, Sümeyye; GÜNAY POLATKAN, ŞEYDA; SERDAR, OSMAN AKIN; Özyılmaz, Sinem Özbay; Dereli, Seçkin; AYDINLAR, ALİ; Baran, İbrahim; ÖZDEMİR, BÜLENT; YEŞİLBURSA, DİLEK; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı; 0000-0003-1744-8883; 0000-0002-7788-9739; 0000-0003-0090-3835; AAF-5116-2019; AAG-8709-2020; AAI-5350-2021; AAI-6632-2021; AAJ-3962-2020; AAB-5861-2021; CDA-1396-2022; JHE-3353-2023; EHA-0046-2022; JGR-6552-2023Publication Acute coronary syndromes(Galenos Yayincilik, 2008-01-01) Aktürk, Yusuf; Serdar, Osman Akın; SERDAR, OSMAN AKIN; Sur, Ülkü; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0003-1744-8883; AAF-5116-2019Acute coronary syndromes has been defined as cardiovascular diseases with acute myocardial ischemia conditions which is one of the most important cause of death and in increasing frequency. It's very important because of their high rates of mortality and complications.Recent developments in both medical treatment and invasive procedures has increased the treatment success and influenced the prognosis favorably. Coronary care units and patient care has an important role in this clinical condition.Publication Evaluation of the association between serum uric acid level and the predicted risk score of sudden cardiac death in five years in patients with hypertrophic cardiomyopathy(Kare Yayınevi, 2018-03-01) Özyılmaz, Sinem; Satılmişoğlu, Muhammet Hulusi; Gül, Mehmet; Uyarel, Hüseyin; Serdar, Osman Akın; SERDAR, OSMAN AKIN; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; AAF-5116-2019Objective: The aim of this study was to determine the relationship between serum uric acid (UA) level and the predicted risk score for sudden cardiac death in 5 years (the HCM Risk-SCD), galectin-3 level, and positive fragmented QRS (fQRS) on electrocardiography (ECG) in patients with hypertrophic cardiomyopathy (HCM).Methods: This was a prospective, observational study. In all, 115 consecutive patients (age > 17 years) with HCM and 80 healthy participants were included in the study. The HCM Risk-SCD score (%), galectin-3 level, and fQRS on ECG were evaluated in all patients.Results: The serum UA, galectin-3 level, UA/Creatinine ratio, incidence of ventricular tachycardia (VT) and syncope, and some echocardiographic parameters were significantly higher in the patient group than in the control group (all p<0.05). The UA value was significantly higher in patients with a high score on the HCM Risk-SCD, a positive fQRS, a high galectin-3 level, VT incidence, and need for implantable cardioverter defibrillator (ICD) implantation or cardiopulmonary resuscitation (CPR) than in those without (HCM Risk-SCD >6%. Namely, HCM Risk-SCD >6%, UA: 6.71 +/- 1.29 mg/dL, HCM Risk-SCD <= 5.9%, UA: 5.84 +/- 1.39 mg/dL, p=0.001; fQRS(+), UA: 6.56 +/- 1.20 mg/dL, fQRS(-), UA: 5.63 +/- 1.49 mg/dL, p<0.001; galectin-3 >6.320 pg/mL, UA: 6.56 +/- 1.27 mg/dL, galectin-3 <= 6.310 pg/mL, p=0.016; left atrium anterior-posterior dimension (LAAPD) > 36 mm, UA: 6.31 +/- 1.33 mg/dL, LAAPD <36 mm, UA: 5.20 +/- 1.60 mg/dL, p=0.005; VT(+), UA: 6.83 +/- 1.19 mg/dL, VT(-), UA: 5.97 +/- 1.42 mg/dL, p=0.008; ICD(+), UA: 7.08 +/- 0.88 mg/dL, ICD(-), UA: 6.06 +/- 1.42 mg/dL, p=0.022; CPR(+), UA: 7.03 +/- 0.96 mg/dL, CPR(-), UA: 6.04 +/- 1.42 mg/dL, p=0.018. A statistically significant correlation was observed between UA and HCM Risk-SCD, galectin-3 level, LAAPD, and left ventricular (LV) mass (LVM) (r and p values, respectively: 0.355, <0.001; 0.297, 0.002; 0.309, 0.001; 0.276, 0.003.Conclusion: The serum UA level was significantly higher in patients with HCM compared with the control group. A high UA level was associated with a higher HCM Risk-SCD score, positive fQRS, higher galectin-3 level, greater LAAPD, VT incidence, and the need for ICD implantation and CPR in patients with HCM.Publication Comparison of pneumatic compression device and sand bag with respect to peripheral vascular complications in elective cardiac catheterization and percutaneous femoral artery interventions(Turkish Soc Cardiology, 2013-09-01) Besli, Feyzullah; Alışır, Mehmet Fethi; Keçebaş, Mesut; Serdar, Osman Akin; SERDAR, OSMAN AKIN; Güngören, Fatih; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-6206-8700; 0000-0003-1744-8883; AAF-5116-2019; AAA-3163-2021Objectives: After coronary angiography (CAG) and percutaneous coronary intervention (PCI), the classic sand bag method and compression devices are widely used for control of bleeding and prevention of vascular complications on the intervention site. The purpose of our study was to assess the major peripheral vascular complications and compare the sand bag and a pneumatic compression device ("Close Pad") in terms of major peripheral vascular complications occurring after CAG, and PCI.Study design: Between June 2011 and November 2011, a total of 434 patients who were admitted to the Department of Cardiology of Uludag University Faculty of Medicine were included in the study. 396 patients underwent coronary angiography and 38 patients, PCI. Sand bag, and Close Pad were applied in 209, and 225 patients, respectively. Bleeding requiring transfusion, hematomas larger than 10 cm(2), pseudoaneurysm, and arteriovenous (AV) fistula were defined as the major local complications. Logistic regression analysis were used to evaluate the data.Results: Major vascular complications occurred in 2% of diagnostic angiography and in 13.2% of PCIs (p=0.003). The major vascular complications were significantly higher with the Close Pad device compared with sand bag (5.3% vs. 0.5%, p=0.007). Smoking, PCI, Close Pad application, use of clopidogrel, and anticoagulants were observed to have increased risk for major local complications. In the logistic regression analysis, only smoking and Close Pad usage were evaluated as independent variables that increased the risk of major vascular complications (p<0.05).Conclusion: Close Pad usage increases risk of vascular complications when compared with the sand bag in patients undergoing cardiac catheterizations. Especially after PCI, patients who will use Close Pad should be selected carefullyPublication Dislodgement of a sirolimus-eluting stent in the circumflex artery and its successful deployment with a small-balloon technique(Turkish Soc Cardiology, 2011-07-01) Şentürk, Tunay; YEŞİLBURSA, DİLEK; ŞENTÜRK, TUNAY; ÖZDEMİR, BÜLENT; Özdemir, Bülent; Serdar, Osman Akın; SERDAR, OSMAN AKIN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0003-1744-8883; AAF-5116-2019; C-1517-2017Coronary stent dislodgement or embolization before deployment is a rare but serious complication in interventional cardiology. A 60-year-old male presented with unstable angina five years after coronary artery bypass surgery. There was a stenosis (70%) in the obtuse marginal branch of the circumflex artery. During percutaneous coronary intervention, a sirolimus-eluting stent was stripped from its balloon mainly because of significant proximal angulation and incarcerated within the proximal circumflex artery. A smaller balloon dilatation catheter was advanced and pushed through the inside of the slipped stent. Using this technique, the stent could be advanced into the lesion and was successfully deployed. To our knowledge, this is the first case report on sirolimus-eluting stent dislodgement.Publication Arterial elasticity measurement in patients with Behcet's disease(Elsevier Science Inc, 2013-10-29) Uçar, Hakan; Karaağaç, Kemal; Aktürk, Yusuf; Serdar, Osman Akin; SERDAR, OSMAN AKIN; Saricaoglu, Hayriye; SARICAOĞLU, HAYRİYE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0003-1744-8883; AAF-5116-2019Publication The relationship of acute exacerbation severity with uric acid and uric acid to creatinine ratio in patients with chronic obstructive pulmonary disease(Galenos Yayincilik, 2013-12-01) Özyılmaz, İsa; Özyılmaz, Sinem Ozbay; Serdar, Osman Akın; SERDAR, OSMAN AKIN; Uzaslan, Esra; UZASLAN, AYŞE ESRA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 0000-0003-1744-8883; AAJ-3962-2020; AAG-8709-2020; AAF-5116-2019Aim: Acute exacerbation in chronic obstructive pulmonary disease (COPD) may result in a lot of systemic consequences due to hypoxemia and systemic inflammation. We investigated uric acid levels and uric acid to creatinine ratio in COPD patients developing acute exacerbation.Methods: We included 25 patients who had been admitted with acute exacerbation of COPD according to the GOLD diagnosis and treatment guidelines between May and December 2011. Uric acid and creatinine levels were recorded from blood samples of the patients.Results: Average uric acid and uric acid to creatinine ratio values were 5.7 +/- 2.09 mg/dl and 7.32 +/- 3.0 in patients with mild hypoxemia, 6.4 +/- 2.1 mg/dl and 7.01 +/- 2.9 in those with moderate hypoxemia, and 6.7 +/- 2.0 mg/dl and 9.1 +/- 1.8 in those with severe hypoxemia, respectively. While no statistically significant correlation was found between uric acid levels and uric acid to creatinine ratio in the three groups (p=0.97, p=0.76, respectively), these values were found to increase along with increasing severity of hypoxemia.Conclusion: Uric acid levels and the ratio of uric acid to creatinine remained unchanged while severity of hypoxemia increased during acute exacerbations of COPD, however, these values were found to increase with increasing severity of hypoxemia.Publication Arterial elasticity measurement in hemodialysis patients and early effect of hemodialysis on vascular compliance(Elsevier Ireland Ltd, 2008-05-01) YEŞİLBURSA, DİLEK; Sağ, Saim; Aktürk, Y.; Dilek, K.; Yeşilbursa, Dilek; Serdar, O.; SERDAR, OSMAN AKIN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0003-1744-8883; AAF-5116-2019; AAW-9185-2020Publication Coronary risk factors and coronary angiography results of 12.201 patients(Elsevier, 2015-07-01) Günay, Şeyda; Serdar, Osman Akın; Özyılmaz, Sinem; Dereli, Seçkin; Aydınlar, Ali; Baran, İbrahim; Özdemir, Burhan; Yeşilbursa, Dilek; Güllülü, Sumeyye; Kaderli, Aysel Aydın; Şentürk, Tunay; GÜNAY POLATKAN, ŞEYDA; SERDAR, OSMAN AKIN; Özyılmaz, Sinem; Dereli, Seçkin; AYDINLAR, ALİ; Baran, İbrahim; Özdemir, Burhan; YEŞİLBURSA, DİLEK; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Kaderli, Aysel Aydın; ŞENTÜRK, TUNAY; Uludağ Üniversitesi; 0000-0003-1744-8883; 0000-0003-0090-3835; 0000-0002-8974-8837; 0000-0003-4829-8400; 0000-0003-0012-345X; AAI-5350-2021; AAI-6632-2021; AAG-8709-2020; AAB-5861-2021; AAJ-3962-2020; C-1517-2017; AAF-5116-2019; CDA-1396-2022; FRF-3343-2022Publication Association between arterial stiffness and acute exacerbations in patients with chronic obstructive pulmonary disease(Aves, 2014-08-01) Özyılmaz, Isa; Özyılmaz, Sinem; Serdar, Osman Akin; SERDAR, OSMAN AKIN; Uzaslan, Esra; UZASLAN, AYŞE ESRA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 0000-0003-1744-8883; AAF-5116-2019; AAG-8709-2020; AAI-1004-2021; AAJ-3962-2020Objective: Acute exacerbation in chronic obstructive pulmonary disease (COPD) can result in a major systemic effect due to hypoxemia and systemic inflammation. In our study, we investigated the effects of acute exacerbation of COPD on arterial stiffness (AS) in patients admitted to our hospital.Methods: Enrolled in the study were 21 healthy volunteers who constituted the control group and 25 patients who had been admitted to our hospital between May and December 2011 with acute exacerbation of COPD diagnosed based on Global Initiative for Chronic Obstructive Lung Disease Diagnosis and Treatment Guidelines.Results: The average AS values were 1498.00+/-699.35 dyne. sec. cm(-5) in patients with mild hypoxemia, 2095.09+/-883.31 dyne. sec. cm(-5) in those with moderate hypoxemia, and 2077.66+/-99.15 dyne. sec. cm(-5) in those with severe hypoxemia. There was no statistically significant correlation between severity of hypoxemia and AS value (p> 0.05). But, there was a statistically significant difference in values of AS, compared between mild hypoxemia (PaO2 >= 60 mm Hg) and moderate and severe hypoxemia (PaO2 < 60 mm Hg) (p= 0.047). Arterial stiffness was significantly higher, while the large artery elasticity index (LAEI) and small artery elasticity index (SAEI) were lower in the patient group as compared to the control group (p= 0.002, p= 0.043, and p= 0.036, respectively).Conclusion: In PaO2 < 60 mmHg AS values were higher than in PaO2 >= 60 mmHg during acute exacerbation of COPD. The AS value was significantly higher while LAEI and SAEI were significantly lower in the patient group as compared to the control group.