Person: DİLEK, KAMİL
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Publication Screening for fabry disease in patients who underwent renal biopsy and identification of a novel mutation(Aves, 2021-04-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Akgür, Suat; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; AKGÜR, SUAT; Aydın, Mehmet Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-4002-2021; HIG-9032-2022; EJA-1761-2022; CPX-5894-2022; EHM-7377-2022; EUF-5229-2022; JGS-9425-2023Background: The X-linked Fabry disease (FD) with lysosomal storage of globotriaosylceramide (Gb3) due to alpha-galactosidase deficiency contributes to nephropathy consisting of proteinuria and renal failure eventually. Early initiation of the enzyme replacement therapy promises favorable renal outcomes. With the importance of early diagnosis, we screened FD among proteinuric patients in whom biopsy findings revealed Fabry nephropathy.Methods: Patients with light microscopic biopsy findings of vacuolated cells, focal and/or segmental glomerular sclerosis, tubular atrophy, and interstitial fibrosis were not associated with particular etiology, the presence of acro-paresthesia, angiokeratomas, and cornea verticillata, stroke history younger than 50 years, family history of renal failure with no cardiovascular risk factors were screened. Fifty-three of 308 consecutive adult patients (45.34 +/- 15.23 years old, 60.1% male) who underwent renal biopsy because of proteinuria were enrolled in the study. Screening for FD was performed by assessing alpha-Gal A activity in dried blood spots (DBS) for males and by genetic testing for females.Results: Fifty-three patients (39.94 +/- 11.97 years, 69.8% male) who underwent renal biopsy were screened. Laboratory findings revealed mean serum creatinine of 1.44 +/- 1.06 mg/dL, mean estimated glomerular filtration rate of 78.31 +/- 39.89 mL/min/1.73 m(2), and mean proteinuria of 4.32 +/- 3 g/day, whereas the females genetic screening was negative. Two of 37 males had low enzyme activity (<0.1 micmol/L/h) and confirmed FD by genetic analysis in whom one had a novel mutation of GLA gene (c.(1047G>A) p.(Trp349*)).Conclusion: It is worth noting that FD screening in patients with proteinuria, in whom vacuolated cells, mesangial expansion, glomerulosclerosis, interstitial fibrosis, and tubular atrophy of unknown etiology, are present in the renal biopsy either with or without a family history of kidney disease.Publication Lower gastrointestinal tract hemorrhage due to ectopic pancreatic tissue in a renal transplant recipient: : A case report(Elsevier, 2002-06-01) Ersoy, Alpaslan; Yavuz, M; Tokyay, R; Yerci, Ömer; Kıyıcı, Murat; Usta, M; Güllülü, Mustafa; Dilek, Kamil; Oktay, B; Yurtkuran, Merih; ERSOY, ALPARSLAN; Yavuz, M; Tokyay, R; YERCİ, ÖMER; KIYICI, MURAT; Usta, M; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; Oktay, B; Yurtkuran, M.; Uludağ Tıp Fakültesi/Tıp Fakültesi/Nefroloji Bölümü; Uludağ Tıp Fakültesi/Tıp Fakültesi/Patoloji Bölümü; Uludağ Tıp Fakültesi/Tıp Fakültesi/Gastroenteroloji Bölümü; Uludağ Tıp Fakültesi/Tıp Fakültesi/Üroloji Bölümü; 0000-0002-3208-6211; AAH-5054-2021; AAI-4213-2021; IHY-2104-2023; DZX-1258-2022; EIS-5114-2022; GGE-6952-2022; JGS-9425-2023; EUU-1912-2022; FRV-0139-2022; EGT-2006-2022Publication A family with IgA nephropathy and hereditary lymphoedema praecox(Wiley, 2002-05-01) Usta, M; Dilek, Kamil; Ersoy, Ahmet; Alper, E; Özbek, Serhat; Özdemir, Bülent; Filiz, G; Yavuz, M; Güllülü, Mustafa; Yurtkuran, Merih; Usta, M; DİLEK, KAMİL; Ersoy, Ahmet; Alper, E; ÖZBEK, SERHAT; ÖZDEMİR, BÜLENT; Filiz, G; Yavuz, M; GÜLLÜLÜ, MUSTAFA; Yurtkuran, Merih; Uludağ Üniversitesi Tıp Fakültesi/Nefroloji Bölümü; Uludağ Üniversitesi Tıp Fakültesi/Nükleer Tıp Bölümü; Uludağ Üniversitesi Tıp Fakültesi/Plastik ve Rekonstrüktif Cerrahi; Uludağ Üniversitesi Tıp Fakültesi/Patoloji Anabilim Dallarından; 0000-0003-3427-8337; 0009-0001-9179-9107; HYD-3798-2023; CNY-9323-2022; GXG-1656-2022; CCY-8570-2022; FTG-3544-2022; JHE-3353-2023; EVQ-8652-2022; HJG-9929-2022; JGS-9425-2023; GLB-5791-2022Immunoglobulin A (IgA) nephropathy is the most common primary glomerulonephritis worldwide. The pathogenesis is still unknown and treatment has not yet been established. Rarely it can be associated with other disorders. Its association with hereditary lymphoedema is not reported before. We report four patients, a 60-year-old father, his two sons and his daughter, with hereditary lymphoedema. The family had nine members and in four of them lymphoedema was evident. The other members had neither lymphoedema nor IgA nephropathy. This is the first report of IgA nephropathy in association with hereditary lymphoedema.Publication Effects of anti-tumor necrosis factor therapy on kidney function in patients with inflammatory arthritis(Oxford Univ Press, 2013-05-01) Öztürk, Oğuzhan; Yıldız, Abdulmecit; Gül, Cuma Bülent; Dilek, Kamil; GÜL, CUMA BÜLENT; DİLEK, KAMİL; Uludağ Üniversitesi/Tıp Fakültesi; 0000-0003-2467-9356; A-7063-2018; EUF-5229-2022Publication A case of behcet's disease concomitant with kaposi's sarcoma(Wolters Kluwer Medknow Publications, 2010-06-01) Erdem, Hatice; Hacıoğlu, Şenay Yıldız; Sarıcaoğlu, Hayriye; Dilek, Kamil; Adım, Şaduman Balaban; Erdem, Hatice; Hacıoğlu, Şenay Yıldız; SARICAOĞLU, HAYRİYE; DİLEK, KAMİL; BALABAN ADIM, ŞADUMAN; Uludağ Üniversitesi/Tıp Fakültesi/Dermatol Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefrol Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; HIZ-7238-2022; ICQ-8894-2023; DPU-8534-2022; EUF-5229-2022; EMN-0789-2022Iatrogenic Kaposi's sarcoma is a subtype of Kaposi's sarcoma (KS), which is a vascular malignant tumor and is seen in organ transplant recipients and in patients receiving immunosuppressive therapy due to other reasons. Iatrogenic KS can develop after corticosteroid or immunosuppressive drug therapy due to systemic lupus erythematosus, rheumatoid arthritis, polymyositis, dermatomyositis, polymyalgia rheumatica and Beh double dagger et's disease, generally with ocular involvement. Our case was a 44-year old male patient. Colchicine and prednisolone were administered for his mucocutaneous findings and polyarthritis. In the seventh month of the therapy, four symmetric, brown-red coloured, asymptomatic macules developed on the inner surface of his left foot. In histopathologic specimens; CD34 positive, atypical spindle cells with swollen nuclei formed bundles and vascular spaces filled with erythrocytes. The patient was diagnosed as KS histopathologically and clinically. HHV-8 DNA was positive with PCR. Regression was observed in the lesions after the cessation of corticosteroid treatment. This case is presented because he was the only case with iatrogenic Kaposi's sarcoma among our Behcet's disease patients receiving corticosteroids or immunosuppressive therapies.Publication Clinical significance of genetic in patients with C3 glomerulopathies(Oxford Univ Press, 2017-05-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Berdeli, Afig; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; Ersoy, Alparslan; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; ERSOY, ALPARSLAN; Uludağ Üniversitesi; 0000-0002-0342-9692; 0000-0002-4791-8367; 0000-0002-0710-0923; AAH-4002-2021; AAH-5054-2021; HIG-9032-2022; EHM-7377-2022; EUF-5229-2022; CTG-8811-2022; AAH-5054-2021Publication Prevalence of transfusion transmitted virus infection and its effect on renal graft survival in renal transplant recipients(Informa Healthcare, 2002-01-01) Usta, M; Dilek, Kamil; Ersoy, A; Özdemir, B; Mıstık, R; Vuruşkan, H; Güllülü, M; Yavuz, M; Oktay, B; Yurtkuran, M; Usta, M; DİLEK, KAMİL; Ersoy, A; Özdemir, B; Mıstık, R; Mıstık, R; Vuruşkan, H; Güllülü, M; Yavuz, M; Oktay, B; Yurtkuran, M; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı; 0000-0002-7528-3557; X-8540-2019; AAH-5054-2021; AAZ-9075-2021; DFY-3761-2022; EFH-9523-2022; CTG-8811-2022; EHM-7377-2022; DKK-2716-2022; EGT-2006-2022Objective: Little is known about the prevalence of transfusion transmitted virus (TTV) infection in renal transplant recipients (RTxs) and its effects on allograft survival. We investigated the prevalence of TTV and its effects on liver injury and graft survival in RTxs.Material and Methods: The study was performed in 33 consecutive RTxs (8 females. 25 males) and 100 blood donors (35 females, 65 males). A nested polymerase chain reaction was used to detect TTV DNA in serum. Serum creatinine and alanine aminotransferase (ALT) levels and 24-h protein excretion were determined in both TTV-positive and -negative patients. The total number of blood transfusions, the duration of hemodialysis and the total duration after transplantation were recorded in RTxs. In addition, hepatitis B surface antigen (HbsAg), anti-hepatitis C virus (HCV) and hepatitis G virus DNA antibodies were determined in all patients.Results: TTV DNA was detected in 51.5% of RTxs and in 7% of the control group and this difference was statistically significant 3<0.01). In the RTx group, 64.7% of TTV-positive and 56.2% of TTV-negative patients had undergone a previous blood transfusion. However, the blood transfusion replacement rate, total duration of dialysis therapy and post-transplant period did not differ between these two groups. Five (15.1%) patients in the RTx group had abnormal liver function tests (ALT >40 IU/l). Of these patients, 2 were anti-HCV-positive, 1 was HBsAg-positive and anti-HCV- plus TTV DNA-positive and the serologic tests of the remaining 2 patients were all negative. Among the TTV-positive patients, 2 (11.7%) were anti-HCV-positive, 1 (5.8%) was HBsAg-positive and 3 (17.6%) were HGV DNA-positive. The baseline serum creatinine levels did not differ significantly between the TTV-positive and -neptive patients, being 1.5 +/- 0.6 and 1.4 +/- 0.6 mg/dl, respectively (p > 0.05). Two of the TTV-positive patients and 1 of the TTV-negative patients had proteinuria. A 1-year follow-up of TTV-positive and -negative patients demonstrated neither acute nor chronic graft rejection.Conclusion: In RTxs, TTV infection was more prevalent than in the normal population. In our patients the virus did not have an important effect on renal graft rejection and did not cause liver injury. However, the question of whether TTV infection may affect graft survival requires further long-term investigation in larger groups.Publication Modified histopathological classification with age-related glomerulosclerosis for predicting kidney survival in ANCA-associated glomerulonephritis(Springer, 2022-09-25) Aydın, Mehmet Fethullah; Yıldız, Abdülmecit; Oruç, Ayşegül; Vuruşkan, Berna Aytaç; Akgür, Suat; Ayar, Yavuz; Güllülü, Mustafa; Dilek, Kamil; Yavuz, Mahmut; Ortaç, Hatice; Ersoy, Alparslan; Aydın, Mehmet Fethullah; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; AYTAÇ VURUŞKAN, BERNA; Ortaç, Hatice; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-0342-9692 ; 0000-0002-5665-7402 ; AAJ-8220-2020; HIG-9032-2022; AAH-4002-2021; EEJ-1452-2022; JGS-9425-2023; EUF-5229-2022; EHM-7377-2022; HJF-9598-2022; CPX-5894-2022Background The histopathological classification of ANCA-GN divides patients into four groups based on signs of glomerular injury. However, this classification did not consider age-related glomerulosclerosis. In this study, we aimed to compare the prediction of renal survival between Berden's ANCA-GN histopathological classification and ANCA-GN histopathological classification modified with age-related glomerulosclerosis. Methods Between January 2004 and December 2019, 65 patients diagnosed with ANCA-GN were enrolled. Demographic, laboratory, and histopathologic findings were retrospectively analyzed. Renal survival analyses were compared according to classical and modified ANCA-GN histopathological classifications. Multivariate Cox regression analysis for the factors affecting renal survival was performed. Results In Berden's ANCA-GN histopathological classification, 15 patients were in the focal group, 21 in the crescentic, 21 in the sclerotic, and 8 in the mixed group. The ANCA-GN histopathological classification model generated statistically significant predictions for renal survival (p = 0.022). When the histopathological classification was modified with age-related glomerulosclerosis, eight of the nine patients previously classified in the sclerotic group were classified in the mixed and one in the crescentic groups. Modification of histopathological classification with age-related glomerulosclerosis increases the statistical significance in renal survival analysis (p = 0.009). The multivariate Cox regression analysis showed that the disease-related global sclerotic glomeruli percentage and serum creatinine level were significant independent factors. Conclusion Modification of Berden's ANCA-GN histopathological classification model with age-related glomerulosclerosis may increase the statistical significance of the histopathological classification model.Publication Goodpasture's syndrome initially presenting with alveolar hemorrhage(Aves, 2007-12-01) Ursavaş, Ahmet; URSAVAŞ, AHMET; Dilek, Kamil; DİLEK, KAMİL; Kahveci, Serdar; Uzarslan, Esra; Gözü, R. Oktay; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; AAI-3169-2021Goodpasture's syndrome is characterized by rapidly progresive glomerulonephritis, presence of deposited and circulating anti-glomerular basement membrane (GBM) antibodies which often accompanied by lung haemorrhage. The antigen target in Goodpasture's syndrome is the alpha 3 chain of type IV collagen. Heamoptysis may be the initial symptom. We present a case of Goodpasture's syndrome presented with diffuse alveolar heamorrhage.Publication Acute effect of hemodialysis on arterial elasticity(TÜBİTAK, 2015-01-01) Sağ, Saim; Yeşilbursa, Dilek; Yıldız, Abdülmecit; Dilek, Kamil; Şentürk, Tunay; Serdar, Osman Akın; Aydınlar, Ali; Sağ, Saim; YEŞİLBURSA, DİLEK; YILDIZ, ABDULMECİT; DİLEK, KAMİL; ŞENTÜRK, TUNAY; SERDAR, OSMAN AKIN; AYDINLAR, ALİ; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0003-1744-8883; 0000-0001-8404-8252; AAW-9185-2020; C-1517-2017; AAF-5116-2019; AAI-6632-2021; EHA-0046-2022; HIG-9032-2022; EUF-5229-2022Background/aim: Reduced arterial elasticity is an independent predictor of cardiovascular mortality in patients with end-stage renal disease (ESRD). Hemodialysis (HD) treatment per se can bring additional risk factors for vascular disease. Our study was designed to determine whether a single hemodialysis session leads to an acute alteration in parameters of arterial elasticity in ESRD.Materials and methods: In this study, 58 patients undergoing chronic hemodialysis and 29 healthy controls were enrolled. Large artery elasticity index (LAEI) and the small artery elasticity index (SAEI) were measured by applanation tonometry. The acute effect of a hemodialysis session on arterial elasticity indices was assessed by comparison of prehemodialysis and posthemodialysis determinations.Results: At baseline, LAEI did not differ significantly in patients compared with controls. In contrast, the SAEI was significantly lower in patients (4.1 +/- 2.6 mL/mmHg x 100) than in healthy individuals (8.9 +/- 3.4 mL/mmHg x 100, P < 0.05). In patients with ESRD, no significant changes in LAEI was observed after HD, but SAEI deteriorated significantly (from 4.1 +/- 2.6 mL/mmHg x 100 to 3.4 +/- 2.3, P < 0.05).Conclusion: We conclude that ESRD patients face a significant reduction in SAEI, which is exacerbated by a dialysis procedure.