Person: YILDIZ, ABDULMECİT
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YILDIZ
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ABDULMECİT
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Publication Membranous nephropathy in Turkey: Turkish society of nephrology glomeruler diseases (tsn-gold) database results(Oxford University Press, 2020-06-01) Yıldız, Abdülmecit; Ulu, Memnune Sena; Oruç, Ayşegül; Uçar, Ali Rıza; Öztürk, Savaş; Alagöz, Selma; Eren, Necmi; Koçyiğit, İsmail; Cevher, Simal Köksal; Haraş, Ali Burak; Sumnu, Abdullah; Arınsoy, Turgay; Şahin, Garip; Süleymanlar, Gültekin; Çavdar, Caner; Gahin, Gizem Kumru; Kurultak, İlhan; Ünsal, Abdülkadir; Şahin, Gülizar Manga; Kazan, Sinan; Vatansever, Bülent; Dikeç, Mehmet; Dursun, Belda; Sayarlıoğlu, Hayriye; Türkmen, Kultiin; Artan, Ayşe Serra; Aktaş, Nimet; Yılmaz, Zülfikar; Behlül, Ahmet; Dheir, Hamad; Kutlay, Sim; Seyahi, Nurhan; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-0342-9692; AAH-4002-2021; HIG-9032-2022Publication The importance of complement levels and clinical characteristics of primary membranoproliferative glomerulonephritis in Turkey(Oxford Univ Press, 2020-06-01) Tatar, Erhan; Oygar, Deren; Seyahi, Nurhan; Eren, Necmi; Cantürk, Yağmur; Güngor, Özkan; Derici, Ulver; Sipahioğlu, Murat; Sümnü, Abdullah; Odabaş, Ali Riza; Turgut, Didem; Çavdar, Caner; Şahin, Garip; Dursun, Belda; Taymez, Dilek Güven; Aydın, Fatma Yılmaz; Ulu, Memnune Sena; Baştürk, Taner; Yadigar, Serap; Bozacı, Ilter; Behlül, Ahmet; Sipahi, Savaş; Bahçebaşı, Zerrin Bicik; Karadag, Serhat; Yıldız, Abdulmecit; YILDIZ, ABDULMECİT; Bursa Uludağ Üniversitesi/Tıp Fakültesi; HIG-9032-2022Publication The effect of smoking on endothelial dysfunction in autosomal dominant polycystic kidney disease patients with preserved renal function(Taylor & Francis, 2021-06-23) Gül, Cuma Bülent; Yıldız, Abdülmecit; Sağ, Saim; Oruç, Ayşegül; Ersoy, Alparslan; Güllülü, Sümeyye; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; ERSOY, ALPARSLAN; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-0342-9692; AAH-4002-2021; HIG-9032-2022; CPX-5894-2022; EXG-3181-2022Background In autosomal dominant polycystic kidney disease (ADPKD), endothelial dysfunction (ED) is common and occurs much earlier than kidney function impairment. The impact of smoking on ED in ADPKD patients has not been previously studied. The aim of this study was to investigate the potential contribution of smoking habits to ED and subclinical atherosclerosis in these patients. Methods This case-control study included 54 ADPKD patients with preserved renal function and 45 healthy control subjects. ED was assessed using ischemia-induced forearm flow-mediated dilatation (FMD). Carotid intima-media thickness (CIMT) was measured from 10 mm proximal to the right common carotid artery. Clinical demographic characteristics and laboratory data were recorded for the patients and control group. Regression analysis was used to determine independent associations of ED and CIMT. Results FMD was significantly lower in the ADPKD patients (19.5 +/- 5.63 vs. 16.56 +/- 6.41, p = .018). Compared with nonsmoker ADPKD patients, smoker patients had significantly lower FMD values (18.19 +/- 6.52 vs. 13.79 +/- 5.27, p = .013). In multiple regression analysis, age (beta = -0.294, 95% CI: -0.392: -1.96, p = .001) for FMD and smoking (beta = 1.328, 95% CI: 0.251, 2.404, p = .017) for CIMT were independent predictors. Conclusions Patients with ADPKD had more impaired endothelial function and subclinical atherosclerosis compared with control subjects. Smoking may increase the risk of subclinical atherosclerosis in ADPKD patients.Publication Screening for fabry disease in patients who underwent renal biopsy and identification of a novel mutation(Aves, 2021-04-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Akgür, Suat; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; AKGÜR, SUAT; Aydın, Mehmet Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-4002-2021; HIG-9032-2022; EJA-1761-2022; CPX-5894-2022; EHM-7377-2022; EUF-5229-2022; JGS-9425-2023Background: The X-linked Fabry disease (FD) with lysosomal storage of globotriaosylceramide (Gb3) due to alpha-galactosidase deficiency contributes to nephropathy consisting of proteinuria and renal failure eventually. Early initiation of the enzyme replacement therapy promises favorable renal outcomes. With the importance of early diagnosis, we screened FD among proteinuric patients in whom biopsy findings revealed Fabry nephropathy.Methods: Patients with light microscopic biopsy findings of vacuolated cells, focal and/or segmental glomerular sclerosis, tubular atrophy, and interstitial fibrosis were not associated with particular etiology, the presence of acro-paresthesia, angiokeratomas, and cornea verticillata, stroke history younger than 50 years, family history of renal failure with no cardiovascular risk factors were screened. Fifty-three of 308 consecutive adult patients (45.34 +/- 15.23 years old, 60.1% male) who underwent renal biopsy because of proteinuria were enrolled in the study. Screening for FD was performed by assessing alpha-Gal A activity in dried blood spots (DBS) for males and by genetic testing for females.Results: Fifty-three patients (39.94 +/- 11.97 years, 69.8% male) who underwent renal biopsy were screened. Laboratory findings revealed mean serum creatinine of 1.44 +/- 1.06 mg/dL, mean estimated glomerular filtration rate of 78.31 +/- 39.89 mL/min/1.73 m(2), and mean proteinuria of 4.32 +/- 3 g/day, whereas the females genetic screening was negative. Two of 37 males had low enzyme activity (<0.1 micmol/L/h) and confirmed FD by genetic analysis in whom one had a novel mutation of GLA gene (c.(1047G>A) p.(Trp349*)).Conclusion: It is worth noting that FD screening in patients with proteinuria, in whom vacuolated cells, mesangial expansion, glomerulosclerosis, interstitial fibrosis, and tubular atrophy of unknown etiology, are present in the renal biopsy either with or without a family history of kidney disease.Publication Combining binary and continuous biomarkers by maximizing the area under the receiver operating characteristic curve(Taylor & Francis, 2020-03-08) Ahmadian, Robab; Ercan, İlker; Sığırlı, Deniz; Yıldız, Abdulmecit; Ahmadian, Robab; ERCAN, İLKER; SIĞIRLI, DENİZ; YILDIZ, ABDULMECİT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0003-1550-639X; 0000-0002-2382-290X; AAE-5602-2019; ABF-2367-2020; AAA-7472-2021; ABF-2368-2020In any clinical case, a decision is made with the maximum possible accuracy. To achieve such accuracy, in the presence of multiple diagnostic tests or biomarkers, biomarker combinations aim to achieve maximum accuracy. As existing biomarker combination methods combine only continuous biomarkers, therefore in this study biomarker combination for binary biomarkers was created by suggesting an approach using Youden's J statistic for combining binary biomarkers. The proposed approach will facilitate binary and continuous biomarker combinations. A simulation study was conducted to compare the performance of our proposed combination approach according to different sample sizes. Both in the analysis of real data and the simulation studies for different samples, the proposed approach has been shown to yield favorable results and higher area under the curve.Publication Effect of parathyroidectomy timing in kidney transplant recipients on graft function(Başkent Üniversitesi, 2021-04-01) Oruc, Aysegul; Ersoy, Alparslan; Yildiz, Abdulmecit; Gul, Ozen Oz; Ersoy, Canan; Oruc, Aysegul; ORUÇ, AYŞEGÜL; Ersoy, Alparslan; ERSOY, ALPARSLAN; Yildiz, Abdulmecit; YILDIZ, ABDULMECİT; Gul, Ozen Oz; ÖZ GÜL, ÖZEN; Ersoy, Canan; ERSOY, CANAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0342-9692; 0000-0002-1332-4165; AAH-8861-2021; AAH-4002-2021Objectives: Persistent hyperparathyroidism can have a deleterious effect on graft function in kidney transplant recipients, although serum calcium, phosphorus, and parathyroid hormone levels tend to normalize after successful transplant. Parathyroidectomy can result in sustained amelioration of persistent hyperparathyroidism despite graft failure risk and unfavorable graft outcomes. Data on this issue are limited and conflicting. Here, we evaluated the effects of parathyroidectomy on graft function in kidney transplant recipients.Materials and Methods: This retrospective study included 249 adult kidney transplant recipients (121 deceased-donor/128 living-donor; 142 males/107 females; mean age of 39.3 +/- 11.6 y; mean follow-up of 46.5 +/- 23.5 mo). Participants were grouped as those without (n = 222), those with pretransplant (n = 12), and those with posttransplant (n = 15) parathyroidectomy. Graft outcomes and serum calcium, phosphorus, and parathyroid hormone levels were studied.Results: Serum calcium levels at baseline and at 1, 3, 6, and 12 months and parathyroid hormone levels at baseline and at 6 and 12 months were higher and serum phosphorus levels at 3, 6, and 12 months were lower in the posttransplant parathyroidectomy group versus the other groups (P <.001). We observed no significant differences between groups regarding serum calcium, phosphorus, and parathyroid hormone levels at last visit. Estimated glomerular filtration rates at 3, 6, and 12 months and at last visit in the pretransplant parathyroidectomy group were higher than in those without parathyroidectomy (P <.05) and higher at 6 and 12 months than in the posttransplant parathyroidectomy group (P <.05). No significant differences regarding graft loss and patient mortality were observed among the 3 groups (P >.05).Conclusions: Parathyroidectomy resulted in sustained decreased levels of serum calcium and parathyroid hormone. We observed no graft failure risk associated with parathyroidectomy in our study. Parathyroidectomy before transplant is advantageous with better graft function.