A case of parry-romberg syndrome: Examining the efficacy of lipofilling by statistical shape analysis

Abstract

Parry-Romberg syndrome is an acquired progressive hemifacial atrophy characterized by the atrophy of subcutaneous fat and bone. The aim of this study was to demonstrate the degree of facial asymmetry before and after treatment with systemic azathioprine and autologous lipofilling. We presented a dramatic case of Parry-Romberg syndrome with central nervous system involvement that was treated with systemic azathioprine and autologous lipofilling. The statistical shape analysis was performed on anatomical landmarks to demonstrate the degree of facial asymmetry before and after therapy. On the face of the subject, 32 anthropometric landmarks on the anterior aspect of the face were defined. Thin-plate spline analysis was performed. Prior to the Thin-plate spline analysis, the right side of the photo was superimposed on the left side of the midsagittal plane and Bookstein coordinates were calculated. After systemic azathioprine and autologous lipofilling, analysis results were evaluated according to the references of the community. While the results were similar to the values of the healthy population in 64% (9/14) of the asymmetry regions, they were different in 29% (4/14). Facial atrophy seen after Parry-Romberg syndrome can include all tissue planes in different grades of severity. Several treatments have been developed to correct this deformity. Lipofilling was demonstrated to decrease the asymmetry to a degree close to the healthy population. © 2013 by Türkiye Klinikleri.