Person: ÖZGENEL, GÜZİN YEŞİM
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ÖZGENEL
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GÜZİN YEŞİM
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Publication The effects of fat graft and platelet-rich fibrin combination after epineurectomy in rats(Assoc Medica Brasileira, 2023-01-01) Kastamoni, Menekşe; KASTAMONİ, MENEKŞE; Yavaş, Senem Esin; Ersoy, Semiha; ERSOY, SEMİHA; Özgenel, Güzin Yeşim; ÖZGENEL, GÜZİN YEŞİM; Tıp FakültesiOBJECTIVE: One of the most important factors that adversely affects the outcome of peripheral nerve surgery is the formation of epineural and extraneural scar tissue after surgery. Many surgical methods and pharmacological and chemical agents have been used to prevent the formation of epineural scar tissue, but satisfactory results have not been achieved in clinical applications. The purpose of this study was to investigate the combined effect of fat graft and platelet-rich fibrin on the formation of epineural scar tissue and on nerve healing in the mature rat model.METHODS: A total of 24 female Sprague-Dawley rats were used. A circumferential segment of epineurium was excised from both bilateral sciatic nerves. The epineurectomized right nerve segment was wrapped with a combination of fat graft and platelet-rich fibrin (experimental group), while the left nerve segment did not receive any surgical procedure other than the epineurectomy (sham group). Notably, 12 randomly selected rats were sacrificed in the fourth week for histopathological examination of early results. The other 12 rats were sacrificed in the eighth week for late results.RESULTS: The formation of fibrosis, inflammation, and myelin degeneration were less common in the experimental group, while nerve regeneration was found to be higher at both 4 and 8 weeks.CONCLUSION: The intraoperative application of a combination of fat graft and platelet-rich fibrin appears to be effective on nerve healing after surgery at both the early and late periods.Publication Outcomes of elderly burn patients requiring hospitalization(Taylor ve Francis, 2015-06-01) Şimşek, Muhammed Eren; Özgenel, G. Yeşim; Kahveci, Ramazan; Akın, Selçuk; Özbek, Serhat; Tufan, Fatih; ÖZGENEL, GÜZİN YEŞİM; KAHVECİ, RAMAZAN; AKIN, SELÇUK; ÖZBEK, SERHAT; Tıp Fakültesi; Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı; 0000-0003-3245-1618; 0000-0003-1683-0722; 0000-0003-0000-8355; AAH-5064-2021; AAH-5441-2021; AAH-4233-2021; AAG-4626-2019Background: The elderly population is more likely to be affected by accidents, such as burns, compared to younger populations because of their diminished host defense. There is limited data about the outcomes of elderly burn patients requiring hospitalization.Methods: In this retrospective study, we assessed the epidemiology and outcomes of burn injuries in elderly patients (>60 years old) admitted to a burn unit of a tertiary medical center based on patient characteristics, type and extent of burns, treatment, hospital stay and mortality rates.Results: Forty-eight elderly burn patients among 870 burn patients during the study period were evaluated. Fire was the most common cause of burns (77.1%). Most of the burns involved more than 20% of total body surface area. Twenty-six (54.2%) patients died during hospitalization. Although burn surface area slightly and non-significantly increased in patients over 75 years, there was a significantly increased mortality rate in these patients. Multivariate linear regression analysis revealed burn area and age as independent associates of mortality.Conclusion: Our data show a high mortality rate in elderly burn patients. Extensive burns and increased age seem to increase the mortality risk.Publication The effect of topical 5-fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve(Marmara Üniversitesi, 2018-01-01) Çavuş Özkan, Melekber; Tuncel, Betül; Özgenel, Güzin Yeşim; ÖZGENEL, GÜZİN YEŞİM; Tıp Fakültesi; Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı; AAH-4233-2021Objective: This study investigated the effect of topical 5-fluorouracil (5-FU) application on the epineural scar tissue, which has a negative impact on the outcome after a peripheral nerve surgery, and whether the application of two doses of 5-FU would change the outcome.Materials and Methods: The study involved 72, 3-month-old female Sprague-Dawley rats weighing 250-300 g each. After the experimental animals were observed for a week to make certain that they were healthy, they were randomly divided into 3 main groups; Group A: skin incision + epineurotomy + isotonic solution (n=24), Group B: skin incision + epineurotomy + single dose of 5-FU (n=24) and Group C: skin incision + epineurotomy + two doses of 5-FU (n=24). Each group was divided into 2 subgroups based on the weeks in which they were examined. The two subgroups in each of the three groups were made subject to a walking test, and macroscopic and histopathological examinations at Week 4 and Week 8.Results: An evaluation of the macroscopic results showed that there was a statistically significant difference between Group A and Group C in sciatic nerve adhesion and severability of its branches. We obtained better results in Group C, when compared with the results obtained in Group A.Conclusion: We demonstrated in our study that 5-FU had a positive effect on the scar tissue developed around the epineurectomized nerve. This positive effect was also reflected in the nerve's functional capacity, and a second dose of 5-FU application further improved this effect.Publication Dressing of the axilla using a water-filled surgical glove after axilla grafting(Springer, 2008-03-01) Aydın, Ufuk; Menderes, V.; Özgenel, Güzin Yeşim; Aydın, Ufuk; Menderes, V.; ÖZGENEL, GÜZİN YEŞİM; Tıp Fakültesi; Plastik Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı; AAH-4233-2021; GTF-3191-2022; FKN-6890-2022Usually, after grafting of the axilla, it is difficult to obtain a reliable dressing using traditional materials including tulls and fluffy gauzes. As an alternative to this traditional approach, a sterile surgical glove filled with saline can be used to obtain a bulky dressing.Publication Treatment of recurrent temporomandibular joint dislocation(Springer India, 2013-12-01) Kahveci, Ramazan; Şimşek, M. Eren; Akın, Selçuk; Özbek, Serhat; Özgenel, Güzin Yeşim; Gökmen, Zeynep Gül; KAHVECİ, RAMAZAN; Şimşek, M. Eren; AKIN, SELÇUK; ÖZBEK, SERHAT; ÖZGENEL, GÜZİN YEŞİM; Gökmen, Zeynep Gül; Tıp Fakültesi; Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı; AAH-5441-2021; AAH-4233-2021; AAH-5064-2021; AAG-4626-2019; IHE-7148-2023; IEB-8849-2023Temporomandibular joint dislocation is defined as the movement of condyle out of the fossa and the advancement of the posterior surface of the condyle in front of the articular eminence. If this condition becomes chronic, surgical treatment is the only option. The goal of surgical treatment is to reposition the condyle and prevent further recurrences. In this study, a retrospective analysis is presented examining 73 patients and 83 joints that were treated with hook-shaped miniplates and miniscrews fixed to otolog bone grafts. Records were obtained from archives of the Uludag University Medical Faculty, Plastic, Reconstructive and Aesthetic Surgery Department. The duration of postoperative follow-up was 3-30 months. In one case, the miniplate was fractured, and in two cases, abscesses existed. This study aims to emphasize that using miniplates and otolog bone grafts is more cost effective.Publication Odontogenic keratocyst seen in three generations(Medknow Publications & Media Pvt Ltd, 2010-09-01) Özgenel, Güzin Yeşim; Özbek, Serhat; Akın, Selçuk; Kahveci, Ramazan; ÖZGENEL, GÜZİN YEŞİM; ÖZBEK, SERHAT; AKIN, SELÇUK; KAHVECİ, RAMAZAN; Tıp Fakültesi; Plastik Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı; AAG-4626-2019; AAH-5064-2021; AAH-5441-2021; AAH-4233-2021Odontogenic keratocyst, being most commonly seen in the jaws, is an epithelial developmental odontogenic cyst which has a high recurrence rate and a rapid growth potential. It is a bening interosseous pathology of the jaw. Most commonly seen clinical signs are swelling and pain at the localization of the cyst. The classic treatment of this pathology is surgical enucleation and curettage being performed through an intraoral approach. Multiple odontogenic cysts are sometimes seen with nevoid basal cell carcinoma syndrome. In this article, cases of odontogenic keratocysts with multiple basal cell carcinoma lesions in the different generations of the same family were presented.