Yayın: Comparison of clinical and molecular wnt and shh subgroups in medulloblastoma tumor cases
Yükleniyor...
Dosyalar
Tarih
2021-01-01
Kurum Yazarları
Kaya, Ismail Seckin
Aksoy, Secil
Mutlu, Melis
Tekin, Cagla
Taskapilioglu, Mevlut Ozgur
Tunca, Berrin
Yazarlar
Kaya, Ismail Seckin
Aksoy, Secil
Mutlu, Melis
Tekin, Cagla
Taskapilioglu, Mevlut Ozgur
Tunca, Berrin
Civan, Muhammet Nafi
Ocak, Pinar Eser
Kocaeli, Hasan
Bekar, Ahmet
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayımcı
Turkish Neurosurgical Soc
Özet
AIM: To determine the Wnt and SHH subtypes at the molecular level, and to compare them clinically by examining the changes in CTNNB1, AXIN, PTCH1, SMO, SUFU, and GLI1 mRNA expression in the medulloblastoma of a Turkish population determined according to patient selection criteria. In this context, the clinical distinction between Wnt and SHH groups are realized by considering the age, gender, survival time, location of the lesion, and radiological features of the patients.MATERIAL and METHODS: Molecular separation was performed by RT-PCR analysis of CTNNB1, AXIN, PTCH1, SMO, SUFU, and GLI1 mRNA expression changes.RESULTS: About 17.8% and 22.2% of the cases were included in the Wnt and the SHH group, respectively. When comparing group differences based on clinical and molecular data, 72.7% and 66.6% of matches were observed in the Wnt and the SHH group, respectively.CONCLUSION: It has been revealed that molecular analysis and grouping of patients with medulloblastoma can provide support for clinically determined subgroups.
Açıklama
Anahtar kelimeler
Expression, Gene, Medulloblastoma, Wnt, Shh, Molecular diagnosis, Science & technology, Life sciences & biomedicine, Clinical neurology, Surgery, Neurosciences & neurology, Surgery