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Comparison of clinical and molecular wnt and shh subgroups in medulloblastoma tumor cases

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dc.contributor.authorKaya, Ismail Seckin
dc.contributor.authorAksoy, Secil
dc.contributor.authorMutlu, Melis
dc.contributor.authorTekin, Cagla
dc.contributor.authorTaskapilioglu, Mevlut Ozgur
dc.contributor.authorTunca, Berrin
dc.contributor.authorCivan, Muhammet Nafi
dc.contributor.authorOcak, Pinar Eser
dc.contributor.authorKocaeli, Hasan
dc.contributor.authorBekar, Ahmet
dc.contributor.authorEgeli, Unal
dc.contributor.authorCecener, Gulsah
dc.contributor.authorTolunay, Sahsine
dc.contributor.buuauthorKaya, Ismail Seckin
dc.contributor.buuauthorKAYA, İSMAİL SEÇKİN
dc.contributor.buuauthorAksoy, Secil
dc.contributor.buuauthorAKSOY, SEÇİL
dc.contributor.buuauthorMutlu, Melis
dc.contributor.buuauthorTekin, Cagla
dc.contributor.buuauthorTaskapilioglu, Mevlut Ozgur
dc.contributor.buuauthorTAŞKAPILIOĞLU, MEVLÜT ÖZGÜR
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorTUNCA, BERRİN
dc.contributor.buuauthorCivan, Muhammet Nafi
dc.contributor.buuauthorOcak, Pinar Eser
dc.contributor.buuauthorKocaeli, Hasan
dc.contributor.buuauthorKOCAELİ, HASAN
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorBEKAR, AHMET
dc.contributor.buuauthorEgeli, Unal
dc.contributor.buuauthorEGELİ, ÜNAL
dc.contributor.buuauthorCecener, Gulsah
dc.contributor.buuauthorÇEÇENER, GÜLŞAH
dc.contributor.buuauthorTolunay, Sahsine
dc.contributor.buuauthorTOLUNAY, ŞAHSİNE
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahi Bölümü.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Medikal Biyoloji Bölümü.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Pataloji Anabilim Dalı.
dc.contributor.orcid0000-0001-5472-9065
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.orcid0000-0003-0132-9927
dc.contributor.orcid0000-0001-7904-883X
dc.contributor.orcid0000-0002-3820-424X
dc.contributor.researcheridAAH-1420-2021
dc.contributor.researcheridAAH-8540-2021
dc.contributor.researcheridABX-9081-2022
dc.contributor.researcheridHKP-0793-2023
dc.contributor.researcheridAAI-2073-2021
dc.date.accessioned2024-06-12T11:44:21Z
dc.date.available2024-06-12T11:44:21Z
dc.date.issued2021-01-01
dc.description.abstractAIM: To determine the Wnt and SHH subtypes at the molecular level, and to compare them clinically by examining the changes in CTNNB1, AXIN, PTCH1, SMO, SUFU, and GLI1 mRNA expression in the medulloblastoma of a Turkish population determined according to patient selection criteria. In this context, the clinical distinction between Wnt and SHH groups are realized by considering the age, gender, survival time, location of the lesion, and radiological features of the patients.MATERIAL and METHODS: Molecular separation was performed by RT-PCR analysis of CTNNB1, AXIN, PTCH1, SMO, SUFU, and GLI1 mRNA expression changes.RESULTS: About 17.8% and 22.2% of the cases were included in the Wnt and the SHH group, respectively. When comparing group differences based on clinical and molecular data, 72.7% and 66.6% of matches were observed in the Wnt and the SHH group, respectively.CONCLUSION: It has been revealed that molecular analysis and grouping of patients with medulloblastoma can provide support for clinically determined subgroups.
dc.identifier.doi10.5137/1019-5149.JTN.32057-20.3
dc.identifier.endpage565
dc.identifier.issn1019-5149
dc.identifier.issue4
dc.identifier.startpage554
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.32057-20.3
dc.identifier.urihttps://hdl.handle.net/11452/42079
dc.identifier.volume31
dc.identifier.wos000672802600011
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.bapOUAP(T)-2019/3.
dc.relation.journalTurkish Neurosurgery
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectExpression
dc.subjectGene
dc.subjectMedulloblastoma
dc.subjectWnt
dc.subjectShh
dc.subjectMolecular diagnosis
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectClinical neurology
dc.subjectSurgery
dc.subjectNeurosciences & neurology
dc.subjectSurgery
dc.titleComparison of clinical and molecular wnt and shh subgroups in medulloblastoma tumor cases
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication121a3732-be5d-4aff-9195-357c8347daca
relation.isAuthorOfPublication077eba38-acbc-49db-8784-0153575936ae
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relation.isAuthorOfPublication.latestForDiscovery3680f3c9-4426-404e-ac7e-a9a4309aa94c

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