Person: TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR
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TAŞKAPILIOĞLU
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MEVLÜT ÖZGÜR
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Publication Retrospective analysis of decompressive craniectomy performed in pediatric patients with subdural hematoma(Travma Acil Cerrahisi, 2019-07-01) Taşkapılıoğlu, Mevlüy Özgür; Özmarasalı, Ali İmran; Ocakoğlu, Gökhan; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; ÖZMARASALI, ALİ İMRAN; OCAKOĞLU, GÖKHAN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0001-5472-9065; 0000-0002-7529-2808; 0000-0002-1114-6051; HLG-6346-2023; AAW-5254-2020; CAI-5927-2022; AAH-5180-2021; ABB-8161-2020BACKGROUND: The impact of decompressive craniectomy (DC) on the overall outcome of pediatric acute subdural hematoma patients has not been fully determined to date. In this paper, we aimed to investigate the role of decompressive craniectomy performed to treat traumatic subdural hematoma in patients from the pediatric age group.METHODS: We described our experience with DC in pediatric acute subdural hematoma patients and analyzed the outcomes.RESULTS: Eleven (7 unilateral and 4 bilateral) DCs were performed. The patients' ages ranged from 8 months to 15 years. The mean GCS score at admission was 7.8. All patients underwent DC with duraplasty within 2 hours of injury. All the patients were admitted to the intensive care unit for 10 days postoperatively. The mean hospital stay was 22 days and the mean follow-up period was 3.7 years.CONCLUSION: Early DC for pediatric subdural hematoma patients, independent of their initial GCS, was recommended. Larger studies are needed to define the indications, surgical techniques, and timing of DC in the pediatric population.Publication NEAT1 Is a novel oncogenic LncRNA and correlated with miR-143 in pediatric oligodendrogliomas(Karger, 2021-03-19) Ak Aksoy, Seçil; Mutlu, Melis; Balçin, Rabia Nur; Taşkapılıoğlu, Mevlut Özgür; Tekin, Çağla; Kaya, Seçkin; Civan, Muhammet Nafi; Kocaeli, Hasan; Bekar, Ahmet; Eser Ocak, Pınar; Çeçener, Gülşah; Egeli, Ünal; Tolunay, Şahsine; Tunca, Berrin; Ak Aksoy, Seçil; Mutlu, Melis; BALÇIN, RABİA NUR; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; Tekin, Çağla; KAYA, İSMAİL SEÇKİN; Civan, Muhammet Nafi; KOCAELİ, HASAN; BEKAR, AHMET; Eser Ocak, Pınar; ÇEÇENER, GÜLŞAH; EGELİ, ÜNAL; TOLUNAY, ŞAHSİNE; TUNCA, BERRİN; Tıp Fakültesi; Beyin Cerrahisi Ana Bilim Dalı; 0000-0001-5472-9065; 0000-0002-4256-2250; 0000-0003-0132-9927; 0000-0002-3820-424X; 0000-0001-7904-883X; 0000-0002-1619-6680; ADM-8457-2022; FPB-0403-2022; GXV-3107-2022; AAW-5254-2020; GDC-6329-2022; JGS-1849-2023; HKP-0793-2023; FDK-3229-2022; CGB-7869-2022; AAI-2073-2021; AAP-9988-2020; AAH-1420-2021; AAI-1612-2021; ABI-6078-2020Introduction: The noncoding RNAs (ncRNAs) play a role in biological processes of various cancers including gliomas. The majority of these transcripts are uniquely expressed in differentiated tissues or specific glioma types. Pediatric oligodendroglioma (POG) is a rare subtype of diffuse glioma and accounts for <1% of pediatric brain tumors. Because histologically POG resembles adult OG, the same treatment is applied as adults. However, the significance in predicting outcomes in POG patients is unclear. In this study, we aimed to investigate the prognostic significance of expression -profiles of microRNA (miRNA) and long noncoding RNA -(LncRNA) in POGs. Methods: We investigated the levels of 13 known miRNAs and 6 LncRNAs in tumor samples from 9 patients with primary POG by using RT-PCR and analyzed their association with outcomes. Results: The expression levels of miR-21, miR-106a, miR-10b, and LncRNA NEAT1 were higher, and the expression level of miR-143 was lower in POG tissues compared with normal brain tissues (p = 0.006, p = 0.032, p = 0.034, p = 0.002, and p = 0.001, respectively). High levels of NEAT1 and low expression of miR-143 were associated with decreased probability of short disease-free survival (p = 0.018 and p = 0.022, respectively). Discussion: NEAT1 and miR-143 levels could serve as reciprocal prognostic predictors of disease progression in patients with POG. New treatment models to regulate the expression levels of NEAT1 and miR-143 will bring a new approach to the therapy of POG.Publication Diabetes mellitus-mediated MALAT1 expression induces glioblastoma aggressiveness(Turkish Neurosurgical Soc, 2023-01-01) Kocaeli, Aysen Akkurt; Aksoy, Seçil A. K.; Erçelik, Melis; Tezcan, Gülçin; Tekin, Çağla; Kocaeli, Hasan; Bekar, Ahmet; Taşkapılıoğlu, Mevlüt Özgür; Tolunay, Şahsine; Tunca, Berrin; AKSOY, SEÇİL; Erçelik, Melis; TEZCAN, GÜLÇİN; Tekin, Çağla; KOCAELİ, HASAN; BEKAR, AHMET; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; TOLUNAY, ŞAHSİNE; TUNCA, BERRİN; Tıp Fakültesi; Tıbbi Biyoloji Ana Bilim Dalı; 0000-0002-3760-9755; ADM-8457-2022; EUG-3329-2022; JJL-1176-2023; GDC-6329-2022; FDK-3229-2022; JWS-5881-2024; IRO-2619-2023; AAI-1612-2021; JXJ-7901-2024AIM: To describe the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in glioblastoma (GB) progression in patients concurrently diagnosed with diabetes mellitus (DM).MATERIAL and METHODS: Formalin-fixed paraffin-embedded (FFPE) tumor samples of 47 patients diagnosed with GB only and 13 patients diagnosed with GB and DM (GB-DM) were enrolled in this study. Data for p53 and Ki67 immunohistochemical staining of the tumors and blood HbA1c levels of patients with DM were retrospectively collected. MALAT1 expression was assessed using quantitative real-time polymerase chain reaction.RESULTS: The coexistence of GB and DM induced the nuclear expression of p53 and Ki67 compared with GB only. MALAT1 expression was higher in GB-DM tumors than in GB only tumors. The expression of MALAT1 and HbA1c levels were positively correlated. Additionally, MALAT1 was positively correlated with tumoral p53 and Ki67. The disease-free survival of patients with GB-DM with high MALAT1 expression was shorter than that of those diagnosed with GB only and with a lower MALAT1 expression.CONCLUSION: Our findings suggest that one of the mechanisms of the facilitating effect of DM on GB tumor aggressiveness is via MALAT1 expression.Publication Statistical shape analysis of cerebellum in patients with chiari malformation I(Lippincott, 2019-09-01) Ocakoğlu, Gökhan; Baykal, Duygu; Altunyuva, Oğuz; Taşkapılıoğlu, Mevlüt Özgür; Yılmazlar, Selçuk; OCAKOĞLU, GÖKHAN; ALTUNYUVA, OĞUZ; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; YILMAZLAR, SELÇUK; Tıp Fakültesi; Beyin Cerrahi Ana Bilim Dalı; 0000-0003-3633-7919; 0000-0002-3450-0471; 0000-0001-5472-9065; ABB-8161-2020; AAW-5254-2020; HLG-6346-2023; AAH-5180-2021; AAK-9899-2020; AAH-5070-2021The surgical procedure is viewed as a typical treatment choice for patients with Chiari malformation (CM). Decompression is the preferred method for surgery, but it is not always possible to understand whether decompression has been successful especially in an early period. The present study focuses on investigating the shape differences in the cerebellums of Chiari patients compared with healthy controls, and to assess the clinical application of this situation whether if present. The MRI scans were reviewed retrospectively. Cerebellar data were obtained from the digital images and 9 anthropometric landmarks were marked on each image. Shape difference was assessed by performing Generalized Procrustes analysis. The cerebellar shape deformation from control to the patient was evaluated performing the Thin Plate Spline approach. There is a statistically significant cerebellar shape difference between groups. Highest deformation was determined at the cerebellar tonsillar inferior area, posterior of the uvula, and anterior of inferior medullary velum. The present study demonstrated cerebellar shape differences in CM I patients using a landmark-based geometric morphometric approach, considering the topographic distribution of cerebellum for the first time.Publication Amount of reoperation following surgical repair of nonsyndromic craniosynostosis at a single center(Tubitak Scientific & Technological Research Council Turkey, 2022-01-01) Baykal, Duygu; Balcin, Rabia Nur; Taskapılıoğlu, Mevlut Özgür; Balcin, Rabia Nur; BALÇIN, RABİA NUR; Taskapılıoğlu, Mevlut Özgür; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; Tıp Fakültesi; Beyin Cerrahisi Ana Bilim Dalı; 0000-0001-9833-9392; 0000-0001-5472-9065; GXV-3107-2022Background/aim: Craniosynostosis is a deformity of the skull that occurs as a result of early fusion of one or more cranial sutures and can be accompanied by neurological deficits. Craniosynostosis can be classified as syndromic or nonsyndromic according to the type of suture involved. Surgical treatment of craniosynostosis in infants basically involves loosening and opening the fused sutures to reduce intracranial pressure, allow the brain to grow, and also fix the skull shape. However, in such cases there is a risk of resynostosis after surgery. According to the literature, resynostosis rates vary between 0% and 70%. In this study, we aimed to evaluate the reoperation rate in craniosynostosis cases treated surgically in our clinic.Material and methods: A retrospective analysis of 70 nonsyndromic craniosynostosis cases treated surgically in the Neurosurgery Department of Bursa Uludag University from 2005 to 2019 was performed. All patients had undergone total cranial vault remodeling surgically and had been followed up for at least a year.Results: The study group included 70 patients, comprising 40 (57.1%) male and 30 (42.9%) female patients. The mean age of the group was 10.9 +/- 7.8 months (range 3-34 months). Out of 70 patients, repeat surgery due to resynostosis had been performed once in 5 (7.1%) patients and twice in 1 (1.4%) patient.Conclusion: It should be kept in mind that resynostosis may occur in patients who have been operated for craniosynostosis. Patients should be examined cosmetically and if necessary, radiologically in the follow-up. Further studies based on larger sample size are recommended for more quantitative data and better results.Publication Effectiveness of multiple endoscopic fenestrations for the treatment of sylvian fissure arachnoid cysts: A multicenter study(Springer, 2022-09-27) Güler, Tuğba Morali; Şahinoğlu, Mert; Şen, Harun Emre; Eker, Oğuzhan; Taşkapılıoğlu, Mevlüt Özgür; Karabağlı, Hakan; Etus, Volkan; EKER, OĞUZHAN; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; Tıp Fakültesi; Beyin Cerrahi Ana Bilim Dalı; 0000-0001-5472-9065 ; GWT-7983-2022; AAW-5254-2020Purpose Arachnoid cysts are usually asymptomatic lesions. However, they can sometimes cause intracranial hypertension, headache, seizures, focal neurological deficits, and bleeding. The most commonly used surgical techniques are microsurgical cyst fenestration/excision/drainage, cyst shunting, and endoscopic procedures. We aimed to investigate the success of different surgical techniques.Methods Between 2000 and 2021, patients with Sylvan fissure arachnoid cysts who received treatment via an endoscopic approach chosen as the first-line treatment in three centers were enrolled. All case notes and radiological studies were evaluated retrospectively.Results The study included 131 (female, n=28; male, n=103) patients with a mean age of 87.04 +/- 66.76 (range, 0-216) months. Of the patients, 25 had Galassi type II left-sided arachnoid cysts, 33 had Galassi type II right-sided arachnoid cysts, 40 had Galassi type III left-sided arachnoid cysts, and 32 had Galassi type III right-sided arachnoid cysts. No difference was found between patients who underwent single and multiple fenestrations in terms of Galassi type, side, clinical outcome, and cyst size (p> 0.05). On the contrary, the rate of additional surgical intervention was lower in patients with multiple fenestrations than in those with single fenestration (36.10% vs. 5.30%; p <0.001).Conclusion Endoscopic fenestration of Sylvian fissure arachnoid cysts is a good alternative to open surgery or cystoperitoneal shunting, and the number of fenestrations made during this surgery decreases the need for a second surgical procedure.Publication Epidemiological comparison between two decades of pediatric head injury hospitalization in Turkey in 2000-2010 and 2011-2020(Turkish Neurosurgical Soc, 2023-01-01) Taşkapılıoğlu, Mevlüt O.; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; Özmaraşali, Ali, I; ÖZMARASALI, ALİ İMRAN; Balcı, Mustafa; Ocakoğlu, Gökhan; OCAKOĞLU, GÖKHAN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-7529-2808; 0000-0001-9912-3948; 0000-0002-1114-6051; JKH-6642-2023; AAH-5180-2021; CAI-5927-2022AIM: To understand the changing trends in pediatric head injury in a university hospital comparing two decades.MATERIAL and METHODS: The medical records of pediatric patients hospitalized for head injuries were evaluated retrospectively between 2000 and 2020 to investigate the epidemiological differences between decades. The patient files were evaluated in terms of age, sex, mechanism of trauma, whether there was additional trauma, radiological findings, Glasgow coma score (GCS), and Rankin scores.RESULTS: A difference was found between the ages of the patients who were hospitalized for head trauma in 2000-2010 (first decade) and 2011-2020 (second decade) (p<0.001). The admission rate of children in the preschool age group was higher in the second decade (p<0.05), whereas the admission rate of school-age children and adolescents was higher in the first decade (p<0.05). The admission rate of patients who had head trauma due to traffic accidents was higher in the first decade (p<0.05). The rate of linear fracture was higher in the second decade (29.90% vs. 55.60%, p<0.05). The incidence of epidural hemorrhage was higher in patients admitted in the first decade (18.50% vs. 7.90%, p<0.05).CONCLUSION: Some classical information has changed over the years. Multicenter studies with a higher number of patients will correct the changing knowledge about pediatric head trauma.Publication Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release(Elsevier, 2023-09-03) Erçelik, Melis; Tekin, Çağla; Parin, Fatma Nur; Mutlu, Büşra; Doğan, Hazal Yılmaz; Tezcan, Gülçin; Aksoy, Seçil Ak; Gürbüz, Melisa; Yıldırım, Kenan; Bekar, Ahmet; Kocaeli, Hasan; Taşkapılıoğlu, Mevlüt Özgür; Eser, Pınar; Tunca, Berrin; Erçelik, Melis; Tekin, Çağla; TEZCAN, GÜLÇİN; Aksoy, Seçil Ak; Gürbüz, Melisa; BEKAR, AHMET; KOCAELİ, HASAN; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; Eser, Pınar; TUNCA, BERRİN; Diş Hekimliği Fakültesi; Beyin Cerrahi Ana Bilim Dalı; 0000-0002-1640-6035; 0000-0003-0132-9927; 0000-0002-1619-6680; ABX-9081-2022; AAI-2073-2021; HKM-7750-2023; EUG-3329-2022; GDC-6329-2022; JJL-1176-2023; JJH-2235-2023; CGB-7869-2022; FDK-3229-2022; IRO-2619-2023Glioblastoma (GB) has susceptibility to post-surgical recurrence. Therefore, local treatment methods are required against recurrent GB cells in the post-surgical area. In this study, we developed a nanofiber-based local therapy against GB cells using Oleuropein (OL), and rutin and their combinations with Temozolomide (TMZ). The polylactic acid (PLA) coreshell nanofiber webs were encapsulated with OL (PLA(OL)), rutin (PLA(rutin)), and TMZ (PLA(TMZ)) by an electrospinning process. A SEM visualized the morphology and the total immersion method determined the release characteristics of PLA webs. Real-time cell tracking analysis for cell growth, dual Acridine Orange/Propidium Iodide staining for cell viability, a scratch wound healing assay for migration capacity, and a sphere formation assay for tumor spheroid aggressiveness were used. All polymeric nanofiber webs had core -shell structures with an average diameter between 133 +/- 30.7-139 +/- 20.5 nm. All PLA webs promoted apoptotic cell death, suppressed cell migration, and spheres growth (p < 0.0001). PLA(OL) and PLA(TMZ) suppressed GB cell viability with a controlled release that increased over 120 h, while PLA(rutin) caused rapid cell inhibition (p < 0.0001). Collectively, our findings suggest that core-shell nanowebs could be a novel and effective therapeutic tool for the controlled release of OL and TMZ against recurrent GB cells.Publication Retrospective analysis of decompressive craniectomy performed in pediatric patients with subdural hematoma(Travma Acil Cerrahisi, 2019-07-01) Taşkapılıoğlu, M. Özgür; Özmarasali, Ali İmran; Ocakoğlu, Gökhan; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; ÖZMARASALI, ALİ İMRAN; OCAKOĞLU, GÖKHAN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0001-5472-9065; 0000-0002-7529-2808; 0000-0002-1114-6051; CAI-5927-2022; AAW-5254-2020; HLG-6346-2023BACKGROUND: The impact of decompressive craniectomy (DC) on the overall outcome of pediatric acute subdural hematoma patients has not been fully determined to date. In this paper, we aimed to investigate the role of decompressive craniectomy performed to treat traumatic subdural hematoma in patients from the pediatric age group.METHODS: We described our experience with DC in pediatric acute subdural hematoma patients and analyzed the outcomes.RESULTS: Eleven (7 unilateral and 4 bilateral) DCs were performed. The patients' ages ranged from 8 months to 15 years. The mean GCS score at admission was 7.8. All patients underwent DC with duraplasty within 2 hours of injury. All the patients were admitted to the intensive care unit for 10 days postoperatively. The mean hospital stay was 22 days and the mean follow-up period was 3.7 years.CONCLUSION: Early DC for pediatric subdural hematoma patients, independent of their initial GCS, was recommended. Larger studies are needed to define the indications, surgical techniques, and timing of DC in the pediatric population.Publication Primary solitary and multiple intracranial hydatid cyst disease: Report of four cases(Aves Yayincilik, Ibrahim Kara, 2018-09-01) Çelebi, Solmaz; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; ÇELEBİ, SOLMAZ; Bozdemir, Şefika Elmas; Hacimustafaoğlu, Mustafa; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; Taşkapılıoğlu, Özgür; Tıp Fakültesi; Pediatri Ana Bilim Dalı; 0000-0001-5472-9065; 0000-0003-4646-660X; ABB-8161-2020Four patients suffered from headache and vomiting at the time of diagnosis. A preoperative diagnosis of the disease was made thanks to cranial magnetic resonance imaging findings and indirect hemagglutination test for Echinococcus granulosus. Of these four children, three had cysts in cerebral localization and one in cerebellar localization. Two children had multiple and one of them had recurrent cerebral hydatid disease. All patients received albendazole treatment. While three patients did well after surgical excision, a ventriculoperitoneal shunt was placed in one. Also, this child was operated for duramater defect. Histopathological nad microbiological studies were performed for surgical specimens. We consider that primary hydatid disease of brain is still a difficult problem despite all advances in diagnostic methods and surgical techniques.