Publication:
Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures

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dc.contributor.buuauthorEgeli, Ünal
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Biyoloji Ana Bilim Dalı
dc.contributor.scopusid55665145000
dc.date.accessioned2022-01-18T10:43:29Z
dc.date.available2022-01-18T10:43:29Z
dc.date.issued1998
dc.description.abstractThis study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/ml. The results of the cytogenetic and statistical evaluations showed that the frequency of SCEs increased significantly in a dose-dependent manner. Thus, it is shown that PYR has a genotoxic effect on human chromosomes.
dc.identifier.citationEgeli, Ü. (1998). "Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures". Teratogenesis Carcinogenesis and Mutagenesis, 18(4), 163-169.
dc.identifier.endpage169
dc.identifier.issn0270-3211
dc.identifier.issue4
dc.identifier.pubmed9804272
dc.identifier.scopus2-s2.0-0031768395
dc.identifier.startpage163
dc.identifier.urihttps://doi.org/10.1002/(SICI)1520-6866(1998)18:4<163::AID-TCM2>3.0.CO;2-L
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/(SICI)1520-6866(1998)18:4%3C163::AID-TCM2%3E3.0.CO;2-L
dc.identifier.urihttp://hdl.handle.net/11452/24137
dc.identifier.volume18
dc.identifier.wos000076584800002
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley-Liss
dc.relation.journalTeratogenesis Carcinogenesis and Mutagenesis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOncology
dc.subjectGenetics & heredity
dc.subjectToxicology
dc.subjectPyrimethamine
dc.subjectSister chromatid exchanges
dc.subjectHuman lymphocyte culture
dc.subjectGenotoxicity
dc.subjectToxoplasmosis
dc.subjectFragile sites
dc.subjectSuspected aneugens
dc.subjectSHL cells
dc.subjectCancer
dc.subjectRearrangements
dc.subjectInvitro
dc.subjectAberrations
dc.subjectAneuploidy
dc.subjectGene
dc.subject.emtreeFolic acid antagonist
dc.subject.emtreePyrimethamine
dc.subject.emtreeArticle
dc.subject.emtreeCarcinogenicity
dc.subject.emtreeCytogenetics
dc.subject.emtreeDna replication
dc.subject.emtreeDrug effect
dc.subject.emtreeEnzyme inhibition
dc.subject.emtreeGenotoxicity
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeLymphocyte culture
dc.subject.emtreeMutagenicity
dc.subject.emtreePeripheral lymphocyte
dc.subject.emtreePriority journal
dc.subject.emtreeProtein induction
dc.subject.emtreeSister chromatid exchange
dc.subject.emtreeToxoplasmosis
dc.subject.meshAdult
dc.subject.meshAntiprotozoal agents
dc.subject.meshCells, cultured
dc.subject.meshDose-response relationship, drug
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymphocytes
dc.subject.meshMale
dc.subject.meshPyrimethamine
dc.subject.meshSister chromatid exchange
dc.subject.scopusHyperpigmentation; Vitamin B 12 Deficiency; Megaloblastic Anemia
dc.subject.wosOncology
dc.subject.wosGenetics & heredity
dc.subject.wosToxicology
dc.titleInduction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Biyoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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