Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures

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dc.contributor.buuauthorEgeli, Ünal
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.scopusid55665145000tr_TR
dc.date.accessioned2022-01-18T10:43:29Z
dc.date.available2022-01-18T10:43:29Z
dc.date.issued1998
dc.description.abstractThis study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/ml. The results of the cytogenetic and statistical evaluations showed that the frequency of SCEs increased significantly in a dose-dependent manner. Thus, it is shown that PYR has a genotoxic effect on human chromosomes.en_US
dc.identifier.citationEgeli, Ü. (1998). "Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures". Teratogenesis Carcinogenesis and Mutagenesis, 18(4), 163-169.en_US
dc.identifier.endpage169tr_TR
dc.identifier.issn0270-3211
dc.identifier.issue4tr_TR
dc.identifier.pubmed9804272tr_TR
dc.identifier.scopus2-s2.0-0031768395tr_TR
dc.identifier.startpage163tr_TR
dc.identifier.urihttps://doi.org/10.1002/(SICI)1520-6866(1998)18:4<163::AID-TCM2>3.0.CO;2-L
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/(SICI)1520-6866(1998)18:4%3C163::AID-TCM2%3E3.0.CO;2-L
dc.identifier.urihttp://hdl.handle.net/11452/24137
dc.identifier.volume18tr_TR
dc.identifier.wos000076584800002tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.journalTeratogenesis Carcinogenesis and Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectGenetics & heredityen_US
dc.subjectToxicologyen_US
dc.subjectPyrimethamineen_US
dc.subjectSister chromatid exchangesen_US
dc.subjectHuman lymphocyte cultureen_US
dc.subjectGenotoxicityen_US
dc.subjectToxoplasmosisen_US
dc.subjectFragile sitesen_US
dc.subjectSuspected aneugensen_US
dc.subjectSHL cellsen_US
dc.subjectCanceren_US
dc.subjectRearrangementsen_US
dc.subjectInvitroen_US
dc.subjectAberrationsen_US
dc.subjectAneuploidyen_US
dc.subjectGeneen_US
dc.subject.emtreeFolic acid antagonisten_US
dc.subject.emtreePyrimethamineen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCarcinogenicityen_US
dc.subject.emtreeCytogeneticsen_US
dc.subject.emtreeDna replicationen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeEnzyme inhibitionen_US
dc.subject.emtreeGenotoxicityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeLymphocyte cultureen_US
dc.subject.emtreeMutagenicityen_US
dc.subject.emtreePeripheral lymphocyteen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein inductionen_US
dc.subject.emtreeSister chromatid exchangeen_US
dc.subject.emtreeToxoplasmosisen_US
dc.subject.meshAdulten_US
dc.subject.meshAntiprotozoal agentsen_US
dc.subject.meshCells, cultureden_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocytesen_US
dc.subject.meshMaleen_US
dc.subject.meshPyrimethamineen_US
dc.subject.meshSister chromatid exchangeen_US
dc.subject.scopusHyperpigmentation; Vitamin B 12 Deficiency; Megaloblastic Anemiaen_US
dc.subject.wosOncologyen_US
dc.subject.wosGenetics & heredityen_US
dc.subject.wosToxicologyen_US
dc.titleInduction of sister chromatid exchanges by pyrimethamine in human lymphocyte culturesen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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