Publication: Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures
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Egeli, Ünal
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Wiley-Liss
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Abstract
This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/ml. The results of the cytogenetic and statistical evaluations showed that the frequency of SCEs increased significantly in a dose-dependent manner. Thus, it is shown that PYR has a genotoxic effect on human chromosomes.
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Keywords
Oncology, Genetics & heredity, Toxicology, Pyrimethamine, Sister chromatid exchanges, Human lymphocyte culture, Genotoxicity, Toxoplasmosis, Fragile sites, Suspected aneugens, SHL cells, Cancer, Rearrangements, Invitro, Aberrations, Aneuploidy, Gene
Citation
Egeli, Ü. (1998). "Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures". Teratogenesis Carcinogenesis and Mutagenesis, 18(4), 163-169.