Yayın: Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in children and adults
Tarih
Kurum Yazarları
İlçol, Yeşim Özarda
Dönmez, Osman
Yavuz, Mahmut
Dilek, Kamil
Yurtkuran, Mustafa
Ulus, İsmail Hakkı
Yazarlar
Danışman
Dil
Türü
Yayıncı:
Pergamon-Elsevier Science
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Özet
Objectives: This study tested whether continuous ambulatory peritoneal dialysis (CAPD) changes free or phospholipid-bound choline concentrations in serum or peritoneal dialysis fluid of patients with end stage renal disease (ESRD).
Design and methods: Serum and dialysate choline and phospholipid-bound choline were measured before, during and after 6 h CAPD.
Results: Serum choline concentrations were higher in patients with ESRD compared with age-matched controls. CAPD lowered serum choline concentrations significantly although it did not influence phospholipid-bound choline. Choline accumulated in the dialysate, reaching 28.4 +/- 2.7 muM in children and 18.2 +/- 1.4 muM in adults, during six hours CAPD; phospholipid-bound choline increased to 22.9 +/- 2.5 muM and 10.8 +/- 1.4 muM in children and adults, respectively. The total daily loss of choline into the dialysate was 181 +/- 20 mumoles in children and 260 +/- 18 mumoles in adults.
Conclusion: CAPD causes a substantial loss of choline into peritoneal dialysates and reduces serum choline concentrations significantly.
Açıklama
Kaynak:
Anahtar Kelimeler:
Konusu
Choline, Phospholipid-bound choline, End stage renal disease, CAPD, Peritoneal dialysis, Rat corpus striatum, Acetylcholine-release, Parenteral-nutrition, Tyrosine-Hydroxylase, Plasma choline, Brain, Metabolism, Deficiency, Transport, Cytidine, Liver, Medical laboratory technology
Alıntı
Özarda, Y. vd. (2002). "Free choline and phospholipid-bound choline concentrations in serum and dialysate during peritoneal dialysis in children and adults". Clinical Biochemistry, 35(4), 307-313.