Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome
dc.contributor.buuauthor | Ursavaş, Ahmet | |
dc.contributor.buuauthor | Karadağ, Mehmet | |
dc.contributor.buuauthor | İlçöz, Yasemin | |
dc.contributor.buuauthor | Ercan, İlker | |
dc.contributor.buuauthor | Burgazoğlu, Başak | |
dc.contributor.buuauthor | Coşkun, Funda | |
dc.contributor.buuauthor | Gözü, R. Oktay | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-3604-8826 | tr_TR |
dc.contributor.orcid | 0000-0002-2382-290X | tr_TR |
dc.contributor.orcid | 0000-0002-9027-1132 | tr_TR |
dc.contributor.researcherid | AAI-3169-2021 | tr_TR |
dc.contributor.researcherid | AAG-8744-2021 | tr_TR |
dc.contributor.researcherid | AAD-1271-2019 | tr_TR |
dc.contributor.researcherid | AAL-8873-2021 | tr_TR |
dc.contributor.scopusid | 8329319900 | tr_TR |
dc.contributor.scopusid | 6601970351 | tr_TR |
dc.contributor.scopusid | 35741320500 | tr_TR |
dc.contributor.scopusid | 6603789069 | tr_TR |
dc.contributor.scopusid | 15836471100 | tr_TR |
dc.contributor.scopusid | 21734137500 | tr_TR |
dc.contributor.scopusid | 15836640800 | tr_TR |
dc.date.accessioned | 2022-09-12T07:59:18Z | |
dc.date.available | 2022-09-12T07:59:18Z | |
dc.date.issued | 2007-09 | |
dc.description.abstract | The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1. | en_US |
dc.identifier.citation | Ursavaş, A. vd. (2007). "Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome". Lung, 185(5), 309-314. | en_US |
dc.identifier.endpage | 314 | tr_TR |
dc.identifier.issn | 0341-2040 | |
dc.identifier.issn | 1432-1750 | |
dc.identifier.issue | 5 | tr_TR |
dc.identifier.pubmed | 17721831 | tr_TR |
dc.identifier.scopus | 2-s2.0-34548577002 | tr_TR |
dc.identifier.startpage | 309 | tr_TR |
dc.identifier.uri | https://doi.org/10.1007/s00408-007-9026-x | |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00408-007-9026-x | |
dc.identifier.uri | http://hdl.handle.net/11452/28638 | |
dc.identifier.volume | 185 | tr_TR |
dc.identifier.wos | 000249459000011 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.journal | Lung | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Insulin-like growth factor | en_US |
dc.subject | Growth-factor-i | en_US |
dc.subject | Respiratory system | en_US |
dc.subject | Obesity | en_US |
dc.subject | Sleep apnea | en_US |
dc.subject | Coronary-artery disease | en_US |
dc.subject | Hormone secretion | en_US |
dc.subject | Somatomedin-c | en_US |
dc.subject | Heart-disease | en_US |
dc.subject | Serum-levels | en_US |
dc.subject | Body-mass | en_US |
dc.subject | Insulin | en_US |
dc.subject | Association | en_US |
dc.subject | Gender | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Oxygen | en_US |
dc.subject.emtree | Somatomedin C | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Apnea | en_US |
dc.subject.emtree | Arousal | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Body mass | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Correlational study | en_US |
dc.subject.emtree | Fatty acid desaturation | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Oxygen saturation | en_US |
dc.subject.emtree | Insulin blood level | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Obesity | en_US |
dc.subject.emtree | Regression analysis | en_US |
dc.subject.emtree | Polysomnography | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Risk factor | en_US |
dc.subject.emtree | Sleep apnea syndrome | en_US |
dc.subject.mesh | Down-regulation | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Cardiovascular diseases | en_US |
dc.subject.mesh | Case-control studies | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Insulin-like growth factor I | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Risk factors | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Obesity | en_US |
dc.subject.mesh | Polysomnography | en_US |
dc.subject.mesh | Severity of illness index | en_US |
dc.subject.mesh | Sleep apnea, obstructive | en_US |
dc.subject.scopus | Obstructive Sleep Apnea; Positive End Expiratory Pressure; Polysomnography | en_US |
dc.subject.wos | Respiratory system | en_US |
dc.title | Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome | en_US |
dc.type | Article | |
dc.wos.quartile | Q4 | en_US |
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