Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome

dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorİlçöz, Yasemin
dc.contributor.buuauthorErcan, İlker
dc.contributor.buuauthorBurgazoğlu, Başak
dc.contributor.buuauthorCoşkun, Funda
dc.contributor.buuauthorGözü, R. Oktay
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-3604-8826tr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.orcid0000-0002-9027-1132tr_TR
dc.contributor.researcheridAAI-3169-2021tr_TR
dc.contributor.researcheridAAG-8744-2021tr_TR
dc.contributor.researcheridAAD-1271-2019tr_TR
dc.contributor.researcheridAAL-8873-2021tr_TR
dc.contributor.scopusid8329319900tr_TR
dc.contributor.scopusid6601970351tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.contributor.scopusid15836471100tr_TR
dc.contributor.scopusid21734137500tr_TR
dc.contributor.scopusid15836640800tr_TR
dc.date.accessioned2022-09-12T07:59:18Z
dc.date.available2022-09-12T07:59:18Z
dc.date.issued2007-09
dc.description.abstractThe aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.en_US
dc.identifier.citationUrsavaş, A. vd. (2007). "Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome". Lung, 185(5), 309-314.en_US
dc.identifier.endpage314tr_TR
dc.identifier.issn0341-2040
dc.identifier.issn1432-1750
dc.identifier.issue5tr_TR
dc.identifier.pubmed17721831tr_TR
dc.identifier.scopus2-s2.0-34548577002tr_TR
dc.identifier.startpage309tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00408-007-9026-x
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00408-007-9026-x
dc.identifier.urihttp://hdl.handle.net/11452/28638
dc.identifier.volume185tr_TR
dc.identifier.wos000249459000011tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.journalLungen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInsulin-like growth factoren_US
dc.subjectGrowth-factor-ien_US
dc.subjectRespiratory systemen_US
dc.subjectObesityen_US
dc.subjectSleep apneaen_US
dc.subjectCoronary-artery diseaseen_US
dc.subjectHormone secretionen_US
dc.subjectSomatomedin-cen_US
dc.subjectHeart-diseaseen_US
dc.subjectSerum-levelsen_US
dc.subjectBody-massen_US
dc.subjectInsulinen_US
dc.subjectAssociationen_US
dc.subjectGenderen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeOxygenen_US
dc.subject.emtreeSomatomedin Cen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeApneaen_US
dc.subject.emtreeArousalen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorrelational studyen_US
dc.subject.emtreeFatty acid desaturationen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeOxygen saturationen_US
dc.subject.emtreeInsulin blood levelen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeObesityen_US
dc.subject.emtreeRegression analysisen_US
dc.subject.emtreePolysomnographyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeSleep apnea syndromeen_US
dc.subject.meshDown-regulationen_US
dc.subject.meshAdulten_US
dc.subject.meshCardiovascular diseasesen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin-like growth factor Ien_US
dc.subject.meshMaleen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshObesityen_US
dc.subject.meshPolysomnographyen_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.meshSleep apnea, obstructiveen_US
dc.subject.scopusObstructive Sleep Apnea; Positive End Expiratory Pressure; Polysomnographyen_US
dc.subject.wosRespiratory systemen_US
dc.titleLow level of IGF-1 in obesity may be related to obstructive sleep apnea syndromeen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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