Publication: Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome
Date
Authors
Ursavaş, Ahmet
Karadağ, Mehmet
İlçöz, Yasemin
Ercan, İlker
Burgazoğlu, Başak
Coşkun, Funda
Gözü, R. Oktay
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Springer
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Abstract
The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.
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Keywords
Insulin-like growth factor, Growth-factor-i, Respiratory system, Obesity, Sleep apnea, Coronary-artery disease, Hormone secretion, Somatomedin-c, Heart-disease, Serum-levels, Body-mass, Insulin, Association, Gender
Citation
Ursavaş, A. vd. (2007). "Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome". Lung, 185(5), 309-314.