Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area
Date
2008-10-15
Authors
Millington, William
Myer, Brian
Cutrera, Rodolfo
Feleder, Carlos
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
We recently reported that the preoptic anterior hypothalamic area (POA) mediates the hypotensive response evoked by lipopolysaccharide (LPS). In this study, we investigated how the inflammatory signal induced by Lips reaches the POA. Subdiaphragmatic vagotomy and abdominal perivagal lidocaine administration, or lidocaine injection into the nucleus tractus solitarius (NTS) prevented LPS hypotension. Microinjection of the alpha-adrenergic receptor antagonist phentolamine into the POA, blocked initiation of the hypotensive response and prevented the late decompensatory phase. These data suggest that LPS hypotension is mediated by the vagus nerve which conveys the signal to the NTS and, in turn, stimulates norepinephrine release within the POA.
Description
Keywords
Alpha-adrenergic receptors, Endotoxic shock, Hypotension, Nucleus tractus solitarius, Vagus nerve, Tumor-necrosis-factor, C-fos expression, Subdiaphragmatic vagotomy, Nitric-oxide, Tnf-alpha, Body-temperature, Endotoxic fever, Guinea-pigs, Cytokines, Rat
Citation
Yılmaz, M.S. vd. (2008). ''Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area''. Journal of Neuroimmunology, 203(1), 39-49.