Publication:
Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area

Simple item page
dc.contributor.authorMillington, William
dc.contributor.authorMyer, Brian
dc.contributor.authorCutrera, Rodolfo
dc.contributor.authorFeleder, Carlos
dc.contributor.buuauthorYılmaz, Mustafa Sertaç
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji ve Klinik Farmakoloji Ana Bilim Dalı
dc.contributor.orcid0000-0001-9496-1475
dc.contributor.researcheridAAH-1571-2021
dc.contributor.researcheridAAH-1448-2021
dc.contributor.scopusid8895544100
dc.contributor.scopusid6508023759
dc.date.accessioned2022-03-14T12:15:29Z
dc.date.available2022-03-14T12:15:29Z
dc.date.issued2008-10-15
dc.description.abstractWe recently reported that the preoptic anterior hypothalamic area (POA) mediates the hypotensive response evoked by lipopolysaccharide (LPS). In this study, we investigated how the inflammatory signal induced by Lips reaches the POA. Subdiaphragmatic vagotomy and abdominal perivagal lidocaine administration, or lidocaine injection into the nucleus tractus solitarius (NTS) prevented LPS hypotension. Microinjection of the alpha-adrenergic receptor antagonist phentolamine into the POA, blocked initiation of the hypotensive response and prevented the late decompensatory phase. These data suggest that LPS hypotension is mediated by the vagus nerve which conveys the signal to the NTS and, in turn, stimulates norepinephrine release within the POA.
dc.description.sponsorshipAlbany College of Pharmacy
dc.identifier.citationYılmaz, M.S. vd. (2008). ''Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area''. Journal of Neuroimmunology, 203(1), 39-49.
dc.identifier.endpage49
dc.identifier.issn0165-5728
dc.identifier.issn1872-8421
dc.identifier.issue1
dc.identifier.pubmed18653249
dc.identifier.scopus2-s2.0-52949137864
dc.identifier.startpage39
dc.identifier.urihttps://doi.org/10.1016/j.jneuroim.2008.06.023
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S016557280800249X
dc.identifier.urihttp://hdl.handle.net/11452/24998
dc.identifier.volume203
dc.identifier.wos000260695200006
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt dışı
dc.relation.journalJournal of Neuroimmunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlpha-adrenergic receptors
dc.subjectEndotoxic shock
dc.subjectHypotension
dc.subjectNucleus tractus solitarius
dc.subjectVagus nerve
dc.subjectTumor-necrosis-factor
dc.subjectC-fos expression
dc.subjectSubdiaphragmatic vagotomy
dc.subjectNitric-oxide
dc.subjectTnf-alpha
dc.subjectBody-temperature
dc.subjectEndotoxic fever
dc.subjectGuinea-pigs
dc.subjectCytokines
dc.subjectRat
dc.subject.emtreeAlpha adrenergic receptor
dc.subject.emtreeLidocaine
dc.subject.emtreeLipopolysaccharide
dc.subject.emtreeNoradrenalin
dc.subject.emtreePhentolamine
dc.subject.emtreePropranolol
dc.subject.emtreeAdrenergic system
dc.subject.emtreeAdrenergic transmission
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeAnterior hypothalamus
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeHypotension
dc.subject.emtreeImmune response
dc.subject.emtreeInflammation
dc.subject.emtreeMale
dc.subject.emtreeNeuropathology
dc.subject.emtreeNonhuman
dc.subject.emtreeNoradrenalin release
dc.subject.emtreePharmacological blocking
dc.subject.emtreePreoptic area
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeSolitary tract nucleus
dc.subject.emtreeVagotomy
dc.subject.emtreeVagus nerve
dc.subject.meshAcute disease
dc.subject.meshAdrenergic alpha-antagonists
dc.subject.meshAnesthetics, local
dc.subject.meshAnimals
dc.subject.meshHypotension
dc.subject.meshLidocaine
dc.subject.meshLipopolysaccharides
dc.subject.meshMale
dc.subject.meshPhentolamine
dc.subject.meshPreoptic -area
dc.subject.meshRats
dc.subject.meshRats, sprague-Dawled
dc.subject.meshReceptors, adrenergic, alpha
dc.subject.meshShock, septic
dc.subject.meshSignal transduction
dc.subject.meshSolitary nucleus
dc.subject.meshVagotomy
dc.subject.meshVagus nerve
dc.subject.scopusIllness Behavior; Leukocyte Endogenous Mediator; Antipyretics
dc.subject.wosImmunology
dc.subject.wosNeurosciences
dc.titleLipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area
dc.typeArticle
dc.wos.quartileQ3
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

İndeksli Yayınlar / Indexed Publications