Publication: Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation
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Authors
Çavun, Sinan
Savcı, Vahide
Ulus, İsmail Hakkı
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Wiley
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Abstract
In the present study, both the effects of intracerebroventricular (i.c.v.) injection of cytidine-5′-diphosphate choline (CDP-choline) on plasma vasopressin levels and the choline involvement of these effects were investigated. I.c.v. administration of CDP-choline (0.5, 1.0 and 2.0 μmol) increased plasma vasopressin levels dose- and time-dependently. I.c.v. injection of equimolar dose of choline (1 μmol) produced similar vasopressin response. However equimolar dose of cytidine (1 μmol; i.c.v.), the other hydrolysis product of CDP-choline, did not affect plasma vasopressin levels. Pretreatment of rats with hemicholinium-3, neuronal high affinity choline uptake inhibitor (20 μg; i.c.v.) blocked the vasopressin response to i.c.v. CDP-choline (1 μmol). Pretreatment of rats with mecamylamine (50 μg; i.c.v.), a nonselective nicotinic receptor antagonist, abolished the increase in plasma vasopressin induced by CDP-choline while atropine (10 μg; i.c.v.), nonselective muscarinic receptor antagonist, failed to change the response. In conclusion, intracerebroventricularly injected CDP-choline can increase plasma vasopressin levels by activating central nicotinic cholinergic receptors through the activation of presynaptic cholinergic mechanisms.
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Keywords
Pharmacology and pharmacy, CDP-choline, Choline, Cytidine, Nicotinic receptor, Precursor, Vasopressin, Rat supraoptic nucleus, Conscious rats, Acetylcholine-receptors, Release, Neurons, Hypothalamus, Involvement, Hippocampal, Hemorrhage, Citicoline
Citation
Çavun, S. vd. (2004). “Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation”. Fundamental and Clinical Pharmacology, 18(1), 71-77.