Publication: Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation
dc.contributor.buuauthor | Çavun, Sinan | |
dc.contributor.buuauthor | Savcı, Vahide | |
dc.contributor.buuauthor | Ulus, İsmail Hakkı | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Tıbbi Farmakoloji Ana Bilim Dalı | |
dc.contributor.researcherid | AAC-9702-2019 | |
dc.contributor.researcherid | D-5340-2015 | |
dc.contributor.scopusid | 6507468595 | |
dc.contributor.scopusid | 6603687024 | |
dc.contributor.scopusid | 7004271086 | |
dc.date.accessioned | 2022-03-14T11:51:24Z | |
dc.date.available | 2022-03-14T11:51:24Z | |
dc.date.issued | 2004-02 | |
dc.description.abstract | In the present study, both the effects of intracerebroventricular (i.c.v.) injection of cytidine-5′-diphosphate choline (CDP-choline) on plasma vasopressin levels and the choline involvement of these effects were investigated. I.c.v. administration of CDP-choline (0.5, 1.0 and 2.0 μmol) increased plasma vasopressin levels dose- and time-dependently. I.c.v. injection of equimolar dose of choline (1 μmol) produced similar vasopressin response. However equimolar dose of cytidine (1 μmol; i.c.v.), the other hydrolysis product of CDP-choline, did not affect plasma vasopressin levels. Pretreatment of rats with hemicholinium-3, neuronal high affinity choline uptake inhibitor (20 μg; i.c.v.) blocked the vasopressin response to i.c.v. CDP-choline (1 μmol). Pretreatment of rats with mecamylamine (50 μg; i.c.v.), a nonselective nicotinic receptor antagonist, abolished the increase in plasma vasopressin induced by CDP-choline while atropine (10 μg; i.c.v.), nonselective muscarinic receptor antagonist, failed to change the response. In conclusion, intracerebroventricularly injected CDP-choline can increase plasma vasopressin levels by activating central nicotinic cholinergic receptors through the activation of presynaptic cholinergic mechanisms. | |
dc.identifier.citation | Çavun, S. vd. (2004). “Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation”. Fundamental and Clinical Pharmacology, 18(1), 71-77. | |
dc.identifier.endpage | 77 | |
dc.identifier.issn | 0767-3981 | |
dc.identifier.issue | 1 | |
dc.identifier.pubmed | 14748757 | |
dc.identifier.scopus | 2-s2.0-1042288132 | |
dc.identifier.startpage | 71 | |
dc.identifier.uri | https://doi.org/10.1046/j.0767-3981.2003.00213.x | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1046/j.0767-3981.2003.00213.x | |
dc.identifier.uri | http://hdl.handle.net/11452/24992 | |
dc.identifier.volume | 18 | |
dc.identifier.wos | 000188963800009 | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.relation.journal | Fundamental and Clinical Pharmacology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Pharmacology and pharmacy | |
dc.subject | CDP-choline | |
dc.subject | Choline | |
dc.subject | Cytidine | |
dc.subject | Nicotinic receptor | |
dc.subject | Precursor | |
dc.subject | Vasopressin | |
dc.subject | Rat supraoptic nucleus | |
dc.subject | Conscious rats | |
dc.subject | Acetylcholine-receptors | |
dc.subject | Release | |
dc.subject | Neurons | |
dc.subject | Hypothalamus | |
dc.subject | Involvement | |
dc.subject | Hippocampal | |
dc.subject | Hemorrhage | |
dc.subject | Citicoline | |
dc.subject.emtree | Atropine | |
dc.subject.emtree | Choline | |
dc.subject.emtree | Citicoline | |
dc.subject.emtree | Cytidine | |
dc.subject.emtree | Hemicholinium 3 | |
dc.subject.emtree | Mecamylamine | |
dc.subject.emtree | Muscarinic receptor blocking agent | |
dc.subject.emtree | Nicotinic receptor | |
dc.subject.emtree | Nicotinic receptor blocking agent | |
dc.subject.emtree | Vasopressin | |
dc.subject.emtree | Animal experiment | |
dc.subject.emtree | Article | |
dc.subject.emtree | Choline uptake | |
dc.subject.emtree | Cholinergic activity | |
dc.subject.emtree | Cholinergic system | |
dc.subject.emtree | Controlled study | |
dc.subject.emtree | Dose time effect relation | |
dc.subject.emtree | Drug effect | |
dc.subject.emtree | Drug hydrolysis | |
dc.subject.emtree | Drug mechanism | |
dc.subject.emtree | Drug response | |
dc.subject.emtree | Inhibition kinetics | |
dc.subject.emtree | Injection | |
dc.subject.emtree | Male | |
dc.subject.emtree | Nonhuman | |
dc.subject.emtree | Presynaptic nerve | |
dc.subject.emtree | Priority journal | |
dc.subject.emtree | Protein blood level | |
dc.subject.emtree | Rat | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Atropine | |
dc.subject.mesh | Cholinergic agents | |
dc.subject.mesh | Cytidine | |
dc.subject.mesh | Cytidine diphosphate choline | |
dc.subject.mesh | Dizocilpine maleate | |
dc.subject.mesh | Dose-response relationship, drug | |
dc.subject.mesh | Excitatory amino acid antagonists | |
dc.subject.mesh | Hemicholinium 3 | |
dc.subject.mesh | Injections, intraventricular | |
dc.subject.mesh | Male | |
dc.subject.mesh | Mecamylamine | |
dc.subject.mesh | Muscarinic antagonists | |
dc.subject.mesh | Nicotinic antagonists | |
dc.subject.mesh | Nootropic agents | |
dc.subject.mesh | Parasympathetic nervous system | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, wistar | |
dc.subject.mesh | Receptors, presynaptic | |
dc.subject.mesh | Stimulation, chemical | |
dc.subject.mesh | Synapses | |
dc.subject.mesh | Vasopressins | |
dc.subject.scopus | Citicoline; Brain Ischemia; Glycerylphosphorylcholine | |
dc.subject.wos | Pharmacology and pharmacy | |
dc.title | Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation | |
dc.type | Article | |
dc.wos.quartile | Q3 | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Tıbbi Farmakoloji Ana Bilim Dalı | |
local.indexed.at | PubMed | |
local.indexed.at | WOS |
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