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Title: Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: The role of vasopressin
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.
Savcı, Vahide
Ulus, İsmail Hakkı
Keywords: Pharmacology & pharmacy
Blood pressure
Nicotinic receptor
Increases acetylcholine-release
Central nervous-system
Brattleboro rats
Corpus striatum
Conscious rats
Issue Date: 12-Sep-1996
Publisher: Elsevier
Citation: Savcı, V. ve Ulus, İ. H. (1996). "Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: The role of vasopressin". European Journal of Pharmacology, 311(2-3), 153-161.
Abstract: The effect of intracerebrovenricularly (i.c.v.) injected choline on blood pressure was investigated in rats made hypotensive by blocking peripheral alpha-adrenoceptors or autonomic ganglionic transmission. Choline (50-150 mu g; i.c.v.) increased blood pressure in a dose-dependent manner and 150 mu g of choline restored blood pressure to the resting level. The presser response to choline was associated with an increase in plasma vasopressin levels. Pretreatment with mecamylamine (50 mu g; i.c.v.), but not atropine (10 mu g; i.c.v.), blocked both the presser and vasopressin responses to i.c.v. choline. The vasopressin receptor antagonist, [beta-mercapto-beta,beta-cyclopenta-methylene-propionyl(1),O-Me-Try(2),Arg(8)]vasopressin (10 mu g/kg; i.v.), given 5 min after i.c.v. choline (150 mu g), abolished the presser effect of choline acid blood pressure returned to the pre-choline levels. It is concluded that the precursor of acetylcholine, choline, can increase blood pressure and reverse hypotension in alpha-adrenoceptor or ganglionic transmission blocked rats, by increasing plasma vasopressin.
ISSN: 0014-2999
Appears in Collections:Scopus
Web of Science

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