Publication:
Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: The role of vasopressin

dc.contributor.buuauthorSavcı, Vahide
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.researcheridD-5340-2015
dc.date.accessioned2021-08-18T07:38:14Z
dc.date.available2021-08-18T07:38:14Z
dc.date.issued1996-09-12
dc.description.abstractThe effect of intracerebrovenricularly (i.c.v.) injected choline on blood pressure was investigated in rats made hypotensive by blocking peripheral alpha-adrenoceptors or autonomic ganglionic transmission. Choline (50-150 mu g; i.c.v.) increased blood pressure in a dose-dependent manner and 150 mu g of choline restored blood pressure to the resting level. The presser response to choline was associated with an increase in plasma vasopressin levels. Pretreatment with mecamylamine (50 mu g; i.c.v.), but not atropine (10 mu g; i.c.v.), blocked both the presser and vasopressin responses to i.c.v. choline. The vasopressin receptor antagonist, [beta-mercapto-beta,beta-cyclopenta-methylene-propionyl(1),O-Me-Try(2),Arg(8)]vasopressin (10 mu g/kg; i.v.), given 5 min after i.c.v. choline (150 mu g), abolished the presser effect of choline acid blood pressure returned to the pre-choline levels. It is concluded that the precursor of acetylcholine, choline, can increase blood pressure and reverse hypotension in alpha-adrenoceptor or ganglionic transmission blocked rats, by increasing plasma vasopressin.
dc.identifier.citationSavcı, V. ve Ulus, İ. H. (1996). "Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: The role of vasopressin". European Journal of Pharmacology, 311(2-3), 153-161.
dc.identifier.endpage161
dc.identifier.issn0014-2999
dc.identifier.issue2-3
dc.identifier.pubmed8891595
dc.identifier.scopus2-s2.0-0030581485
dc.identifier.startpage153
dc.identifier.urihttps://doi.org/10.1016/0014-2999(96)00424-4
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/0014299996004244
dc.identifier.urihttp://hdl.handle.net/11452/21456
dc.identifier.volume311
dc.identifier.wosA1996VJ94200008
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.journalEuropean Journal of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPharmacology & pharmacy
dc.subjectCholine
dc.subjectAcetylcholine
dc.subjectBlood pressure
dc.subjectHypotension
dc.subjectVasopressin
dc.subjectNicotinic receptor
dc.subjectIncreases acetylcholine-release
dc.subjectCentral nervous-system
dc.subjectHemorrhagic-shock
dc.subjectTyrosine-hydroxylase
dc.subjectBlood-pressure
dc.subjectCardiovascular-responses
dc.subjectBrattleboro rats
dc.subjectCorpus striatum
dc.subjectConscious rats
dc.subjectLong-evans
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholine
dc.subject.wosPharmacology & pharmacy
dc.titleCentral choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: The role of vasopressin
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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