Publication: Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: The role of vasopressin
dc.contributor.buuauthor | Savcı, Vahide | |
dc.contributor.buuauthor | Ulus, İsmail Hakkı | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Farmakoloji Ana Bilim Dalı | |
dc.contributor.researcherid | D-5340-2015 | |
dc.date.accessioned | 2021-08-18T07:38:14Z | |
dc.date.available | 2021-08-18T07:38:14Z | |
dc.date.issued | 1996-09-12 | |
dc.description.abstract | The effect of intracerebrovenricularly (i.c.v.) injected choline on blood pressure was investigated in rats made hypotensive by blocking peripheral alpha-adrenoceptors or autonomic ganglionic transmission. Choline (50-150 mu g; i.c.v.) increased blood pressure in a dose-dependent manner and 150 mu g of choline restored blood pressure to the resting level. The presser response to choline was associated with an increase in plasma vasopressin levels. Pretreatment with mecamylamine (50 mu g; i.c.v.), but not atropine (10 mu g; i.c.v.), blocked both the presser and vasopressin responses to i.c.v. choline. The vasopressin receptor antagonist, [beta-mercapto-beta,beta-cyclopenta-methylene-propionyl(1),O-Me-Try(2),Arg(8)]vasopressin (10 mu g/kg; i.v.), given 5 min after i.c.v. choline (150 mu g), abolished the presser effect of choline acid blood pressure returned to the pre-choline levels. It is concluded that the precursor of acetylcholine, choline, can increase blood pressure and reverse hypotension in alpha-adrenoceptor or ganglionic transmission blocked rats, by increasing plasma vasopressin. | |
dc.identifier.citation | Savcı, V. ve Ulus, İ. H. (1996). "Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: The role of vasopressin". European Journal of Pharmacology, 311(2-3), 153-161. | |
dc.identifier.endpage | 161 | |
dc.identifier.issn | 0014-2999 | |
dc.identifier.issue | 2-3 | |
dc.identifier.pubmed | 8891595 | |
dc.identifier.scopus | 2-s2.0-0030581485 | |
dc.identifier.startpage | 153 | |
dc.identifier.uri | https://doi.org/10.1016/0014-2999(96)00424-4 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/0014299996004244 | |
dc.identifier.uri | http://hdl.handle.net/11452/21456 | |
dc.identifier.volume | 311 | |
dc.identifier.wos | A1996VJ94200008 | |
dc.indexed.wos | SCIE | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.relation.journal | European Journal of Pharmacology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Pharmacology & pharmacy | |
dc.subject | Choline | |
dc.subject | Acetylcholine | |
dc.subject | Blood pressure | |
dc.subject | Hypotension | |
dc.subject | Vasopressin | |
dc.subject | Nicotinic receptor | |
dc.subject | Increases acetylcholine-release | |
dc.subject | Central nervous-system | |
dc.subject | Hemorrhagic-shock | |
dc.subject | Tyrosine-hydroxylase | |
dc.subject | Blood-pressure | |
dc.subject | Cardiovascular-responses | |
dc.subject | Brattleboro rats | |
dc.subject | Corpus striatum | |
dc.subject | Conscious rats | |
dc.subject | Long-evans | |
dc.subject.scopus | Citicoline; Neuroprotective Agents; Glycerylphosphorylcholine | |
dc.subject.wos | Pharmacology & pharmacy | |
dc.title | Central choline reverses hypotension caused by alpha-adrenoceptor or ganglion blockade in rats: The role of vasopressin | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Farmakoloji Ana Bilim Dalı | |
local.indexed.at | Scopus | |
local.indexed.at | WOS |
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