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Nutritional modifiers of aging brain function: Use of uridine and other phosphatide precursors to increase formation of brain synapses

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dc.contributor.authorWurtman, Richard J.
dc.contributor.authorSakamoto, Toshimasa
dc.contributor.authorUlus, İsmael
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Farmakoloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-2918-5064
dc.contributor.researcheridM-9071-2019
dc.contributor.scopusid8872816100
dc.date.accessioned2021-11-10T08:50:28Z
dc.date.available2021-11-10T08:50:28Z
dc.date.issued2010-12
dc.description.abstractBrain phosphatide synthesis requires three circulating compounds: docosahexaenoic acid (DHA), uridine, and choline. Oral administration of these phosphatide precursors to experimental animals increases the levels of phosphatides and synaptic proteins in the brain and per brain cell as well as the numbers of dendritic spines on hippocampal neurons. Arachidonic acid fails to reproduce these effects of DHA. If similar increases occur in human brain, administration of these compounds to patients with diseases that cause loss of brain synapses, such as Alzheimer's disease, could be beneficial.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Mental Health (NIMH) (R01MH028783)
dc.identifier.citationWurtman, Richard. J. vd. (2010). "Nutritional modifiers of aging brain function: Use of uridine and other phosphatide precursors to increase formation of brain synapses". Nutrition Reviews, 68(12), 88-101.
dc.identifier.endpage101
dc.identifier.issn0029-6643
dc.identifier.issn1753-4887
dc.identifier.issue12
dc.identifier.pubmed21091953
dc.identifier.scopus2-s2.0-78649436932
dc.identifier.startpage88
dc.identifier.urihttps://doi.org/10.1111/j.1753-4887.2010.00344.x
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/21091953/
dc.identifier.urihttp://hdl.handle.net/11452/22616
dc.identifier.volume68
dc.identifier.wos000284587300006
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherOxford University Press
dc.relation.collaborationYurt içi
dc.relation.collaborationYurt dışı
dc.relation.collaborationSanayi
dc.relation.journalNutrition Reviews
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAging brain function
dc.subjectNutritional modifiers
dc.subjectPhosphatide precursors
dc.subjectUridine
dc.subjectPlus docosahexaenoic acid
dc.subjectCDP-choline levels
dc.subjectRat-brain
dc.subjectAlzheimers-disease
dc.subjectFatty-acid
dc.subjectNeurite outgrowth
dc.subjectPheochromocytoma cells
dc.subjectTranscription factors
dc.subjectGlutamate receptors
dc.subjectSynaptic plasticity
dc.subjectNutrition & dietetics
dc.subjectAnimalia
dc.subject.emtreeCholine
dc.subject.emtreeDocosahexaenoic acid
dc.subject.emtreeOmega 3 fatty acid
dc.subject.emtreeUridine
dc.subject.emtreeAlzheimer disease
dc.subject.emtreeArticle
dc.subject.emtreeBehavior
dc.subject.emtreeBrain cell
dc.subject.emtreeBrain development
dc.subject.emtreeBrain function
dc.subject.emtreeClinical trial
dc.subject.emtreeCognition
dc.subject.emtreeHuman
dc.subject.emtreeNerve cell network
dc.subject.emtreeNeurite
dc.subject.emtreeNonhuman
dc.subject.emtreeProtein synthesis
dc.subject.emtreeSynapse
dc.subject.emtreeSynaptic membrane
dc.subject.emtreeSynaptogenesis
dc.subject.emtreeVerbal memory
dc.subject.scopusCholine Phosphate Cytidylyltransferase; Phosphatidylcholines; Citicoline
dc.subject.wosNutrition & dietetics
dc.titleNutritional modifiers of aging brain function: Use of uridine and other phosphatide precursors to increase formation of brain synapses
dc.typeArticle
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Farmakoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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