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Immunohistochemical localization of transforming growth factor beta(1) and beta(2) in mouse testes during postnatal development

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dc.contributor.buuauthorÖzgüden, Cansel Güzin Akkoç
dc.contributor.buuauthorÖzer, Aytekin
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentHistoloji Embriyoloji Ana Bilim Dalı
dc.contributor.scopusid36138936300
dc.contributor.scopusid7005139374
dc.date.accessioned2022-05-06T06:08:37Z
dc.date.available2022-05-06T06:08:37Z
dc.date.issued2012-02
dc.description.abstractWe examined age-related changes in the expression of transforming growth factor-beta(1) (TGF-beta(1)) and transforming growth factor-beta(2) in mouse testes. The mice were assigned to three age groups: 35, 50, and 75 days old. Paraffin embedded testis sections were processed for the standard streptavidin biotin peroxidase complex immunohistochemistry method. TGF-beta(1) expression increased in aging round spermatids over the time studied. There was no expression in 35-day-old Leydig cells, whereas strong expression of TGF-beta(1) was observed in 50-day-old Leydig cells. Expression decreased in 75-day-old Leydig cells. TGF-beta(2) expression was weak in 35- and 50-day-old mouse spermatids, but expression was greater in 75-day-old elongated spermatids. In Leydig cells, TGF-beta(2) expression was strong in both 35- and 50-day-old mice, whereas the expression of TGF-beta(2) was less in 75-day-old Leydig cells. Our results suggest that TGF-beta(1) and TGF-beta(2) may play significant roles in testicular functions and germ cell development in mice.
dc.identifier.citationÖzgüden C. G. A. ve Özer, A. (2012). "Immunohistochemical localization of transforming growth factor beta(1) and beta(2) in mouse testes during postnatal development". Biotechnic & Histochemistry, 87(2), 154-159.
dc.identifier.doi10.3109/10520295.2011.592150
dc.identifier.endpage159
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue2
dc.identifier.pubmed21905961
dc.identifier.scopus2-s2.0-84855464783
dc.identifier.startpage154
dc.identifier.urihttps://doi.org/10.3109/10520295.2011.592150
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/10520295.2011.592150
dc.identifier.urihttp://hdl.handle.net/11452/26291
dc.identifier.volume87
dc.identifier.wos000313111600011
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.journalBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak105 O 348
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiotechnology & applied microbiology
dc.subjectCell biology
dc.subjectImmunohistochemistry
dc.subjectMouse
dc.subjectTestis
dc.subjectTgf-beta(1)
dc.subjectTgf-beta(2)
dc.subjectII receptors
dc.subjectTgf-beta
dc.subjectExpression
dc.subjectSpermatogenesis
dc.subjectProtein
dc.subjectMus
dc.subject.emtreeTransforming growth factor beta1
dc.subject.emtreeTransforming growth factor beta2
dc.subject.emtreeAge
dc.subject.emtreeAnimal
dc.subject.emtreeArticle
dc.subject.emtreeChemistry
dc.subject.emtreeGerm cell
dc.subject.emtreeGrowth, development and aging
dc.subject.emtreeImmunohistochemistry
dc.subject.emtreeLeydig cell
dc.subject.emtreeMale
dc.subject.emtreeMouse
dc.subject.emtreeSpermatid
dc.subject.emtreeTestis
dc.subject.meshAge factors
dc.subject.meshAnimals
dc.subject.meshGerm cells
dc.subject.meshImmunohistochemistry
dc.subject.meshLeydig cells
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshSpermatids
dc.subject.meshTestis
dc.subject.meshTransforming growth factor beta1
dc.subject.meshTransforming growth factor beta2
dc.subject.scopusSertoli Cells; Azoospermia; Neovison Vison
dc.subject.wosBiotechnology & applied microbiology
dc.subject.wosCell biology
dc.titleImmunohistochemical localization of transforming growth factor beta(1) and beta(2) in mouse testes during postnatal development
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Histoloji Embriyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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