No association between the SOCS-1 −1478CA/del polymorphism and ulcerative colitis in Turkish subjects

Abstract

Suppressor of cytokine signaling (SOCS)-1 is an essential regulator of many cytokine signaling pathways, including those upregulated in the inflamed colonic mucosa of patients with ulcerative colitis. We sought to investigate whether the functional SOCS-1 -1478CA > del polymorphism is associated with UC susceptibility and its disease phenotype in a Turkish clinical sample. A total of 104 subjects were enrolled in a case-control study (52 UC cases and 52 controls). The SOCS-1 -1478CA > del polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The odds ratio of the del allele for UC relative to the CA allele was not significant (OR = 1.04, 95 % CI 0.59-1.82, P = 0.88). These results did not change after adjustment for age and sex in multivariable regression analysis (OR = 1.07, 95 % CI 0.42-1.69, P = 0.73). When the SOCS-1 -1478CA > del polymorphism was analyzed among UC patients according to continuous disease and non-continuous disease, the del allele was not associated with disease recurrence (OR = 1.56, 95 % CI 0.78-4.56, P = 0.83). Furthermore, when we divided UC patients into two groups according to a previous history of colectomy, we found no significant effect of the del allele (OR = 1.94, 95 % CI 0.55-5.61, P = 0.91). Taken together, these findings suggest that SOCS-1 -1478CA > del polymorphism does not contribute to UC susceptibility and its disease phenotype in Turkish subjects.