Publication:
Hemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method

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dc.contributor.authorYılmaz, Begümhan
dc.contributor.authorDoğan, Serap
dc.contributor.buuauthorKasımoğulları, Serap Çelik
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.scopusid8234554800
dc.date.accessioned2023-09-25T11:11:07Z
dc.date.available2023-09-25T11:11:07Z
dc.date.issued2018
dc.description.abstractThe aim of this study was to show the hemocompatibility, cytotoxicity, and genotoxicity of nanocomposites that were synthesized with different molecular weights of poly(methyl methacrylate) (PMMA) and different concentrations of nanohydroxyapatite (nHAp). Different techniques to characterize the nanocomposites were used. The cytotoxicity and genotoxic effects of the polymers and nanocomposites on human lymphocytes were determined by acid phosphatase assay, viability test, and comet assay. Moreover, hemocompatibility test was performed. It was found that all of the PMMA/nHAp nanocomposites are highly hemocompatible and biocompatible, none of the nanocomposites showed a cytotoxic effect, and nHAp addition decreased the genotoxicity.
dc.description.sponsorshipBalıkesir Üniversitesi Bilimsel Araştırma Projeleri Komisyonu BAP 15/120
dc.identifier.citationYılmaz, B. vd. (2018). ''Hemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method''. International Journal of Polymeric Materials and Polymeric Biomaterials, 67(6), 351-360.
dc.identifier.endpage360
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85027382923
dc.identifier.startpage351
dc.identifier.urihttps://doi.org/10.1080/00914037.2017.1331349
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/00914037.2017.1331349
dc.identifier.urihttp://hdl.handle.net/11452/34020
dc.identifier.volume67
dc.identifier.wos000424789900003
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.collaborationYurt içi
dc.relation.journalInternational Journal of Polymeric Materials and Polymeric Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitakTUBITAK
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMaterials science, biomaterials
dc.subjectPolymer science
dc.subjectCytotoxicity
dc.subjectGenotoxicity
dc.subjectHemocompatibility
dc.subjectNanocomposite
dc.subjectNanohydroxyapatite
dc.subjectPMMA
dc.subjectElectrophoresis comet assay
dc.subjectDNA-damage
dc.subjectIn-vitro
dc.subjectHuman-lymphocytes
dc.subjectIndividual cells
dc.subjectResin monomers
dc.subjectComposite
dc.subjectCement
dc.subjectTissue
dc.subjectBone
dc.subjectBiocompatibility
dc.subjectBlending
dc.subjectEsters
dc.subjectNanocomposites
dc.subjectPhosphatases
dc.subjectCytotoxic effects
dc.subjectGenotoxicities
dc.subjectHuman lymphocytes
dc.subjectMelt-blending methods
dc.subjectPoly(methyl methacrylate) (PMMA)
dc.subject.scopusHydroxyapatite-Polylactide; Hydroxyapatite; Bone Regeneration
dc.subject.wosMaterials science, biomaterials
dc.subject.wosPolymer science
dc.titleHemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method
dc.typeArticle
dc.wos.quartileQ3 (Materials science, biomaterials)
dc.wos.quartileQ2 (Polymer science)
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.indexed.atScopus
local.indexed.atWOS

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