Yayın: Hemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method
Tarih
Kurum Yazarları
Kasımoğulları, Serap Çelik
Yazarlar
Yılmaz, Begümhan
Doğan, Serap
Danışman
Dil
Türü
Yayıncı:
Taylor & Francis
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Özet
The aim of this study was to show the hemocompatibility, cytotoxicity, and genotoxicity of nanocomposites that were synthesized with different molecular weights of poly(methyl methacrylate) (PMMA) and different concentrations of nanohydroxyapatite (nHAp). Different techniques to characterize the nanocomposites were used. The cytotoxicity and genotoxic effects of the polymers and nanocomposites on human lymphocytes were determined by acid phosphatase assay, viability test, and comet assay. Moreover, hemocompatibility test was performed. It was found that all of the PMMA/nHAp nanocomposites are highly hemocompatible and biocompatible, none of the nanocomposites showed a cytotoxic effect, and nHAp addition decreased the genotoxicity.
Açıklama
Kaynak:
Anahtar Kelimeler:
Konusu
Materials science, biomaterials, Polymer science, Cytotoxicity, Genotoxicity, Hemocompatibility, Nanocomposite, Nanohydroxyapatite, PMMA, Electrophoresis comet assay, DNA-damage, In-vitro, Human-lymphocytes, Individual cells, Resin monomers, Composite, Cement, Tissue, Bone, Biocompatibility, Blending, Esters, Nanocomposites, Phosphatases, Cytotoxic effects, Genotoxicities, Human lymphocytes, Melt-blending methods, Poly(methyl methacrylate) (PMMA)
Alıntı
Yılmaz, B. vd. (2018). ''Hemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method''. International Journal of Polymeric Materials and Polymeric Biomaterials, 67(6), 351-360.