Publication: The relationship between CRP gene polymorphism (rs2794521, rs3091244), ASDAS-CRP and ASDAS-ESR in ankylosing spondylitis
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Date
2019-07-20
Authors
Authors
Aksoy, Meliha Kasapoğlu
Altan, Lale
Görükmez, Orhan
Güner, Altuğ
Ayar, Koray
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor
Abstract
Background: We aimed to investigate the haplotypes and alleles of two variants (rs2794521 and rs3091244) in AS patients and to examine their relationship with ASDAS-CRP and ASDAS-ESR values. Methods: We evaluated 160 AS patients diagnosed according to the ASAS criteria. ASDAS-CRP and ASDAS-ESR values were calculated. ESR and CRP were examined. The restriction fragment length polymorphism (RFLP) method was used for detecting the rs2794521 and rs3091244 regions on the CRP gene. Results: As a result of the evaluation of rs2794521 gene polymorphism using PCR, TT, TC and CC genotypes were observed in 90, 81 and 9 individuals, respectively. As a result of the evaluation of rs3091244 gene polymorphism, CC, AC and TT genotypes were observed in 104, 51 and 5 individuals, respectively. T allele and C allele were found in rs2794521 gene by 75% and 25%, respectively. In addition, T allele, C allele and A allele were found in rs3091244 gene by 80%, 17% and 3%, respectively. With the help of regression equation, ASDAS-CRP level was 0.34 units higher in cases with rs3091244 C allele than cases without rs3091244 C alleles. Conclusion: CRP rs3091244 C allele may be associated with the increased relative risk for ASDAS-CRP.
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Keywords
C-reactive protein, Disease-activity, Association, Hla-b27, Spondyloarthritis, Prediction, Promoter, Cancer, Allele, Snp, Ankylosing spondylitis, Crp gene polymorphism, Asdas crp, Asdas esr, Acute phase reactants, Science & technology, Life sciences & biomedicine, Rheumatology