Person: ALTAN İNCEOĞLU, LALE
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ALTAN İNCEOĞLU
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LALE
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Publication Attitudes of patients with spondylarthritis or rheumatoid arthritis regarding biological treatment during covid-19 pandemic: A multi-center, phone-based, cross-sectional study(Türkiye Romatizma Araştırma ve Savaş Derneği, 2021-12-01) Zateri, Coskun; Birtane, Murat; Aktaş, İlknur; Sarıkaya, Selda; Rezvani, Aylin; Altan, Lale; Dursun, Nigar; Dursun, Erbil; Taştekin, Nurettin; Çeliker, Reyhan; Özdolap, Şenay; Akgün, Kenan; ALTAN İNCEOĞLU, LALE; 0000-0002-7948-5383; 0000-0002-1050-9666; 0000-0002-8015-0513; 0000-0002-6552-7204; AAH-1652-2021Objectives: In this study, we aimed to investigate the medical treatment attitudes of patients with spondylarthritis or rheumatoid arthritis (RA) who were using biological drugs during the novel coronavirus-2019 (COVID-19) pandemic.Patients and methods: In this multi-center, cross-sectional study, a total of 277 patients (178 males, 99 females; median age: 45 years; range, 20 to 77 years) who were using biological disease-modifying anti-rheumatic drugs (bDMARDs) for rheumatic diseases and were reached by phone between June 1st, 2020 and June 30th, 2020 were included. Demographic characteristics, working status, type of the rheumatic disease, comorbidities, smoking habits, and type of the bDMARDs were recorded. Disease activity was evaluated using the Visual Analog Scale (VAS). The patients were asked whether they continued the treatment plan, as it was before or changed and, if changed, how they changed the plan and what happened after the change.Results: Of the patients, 229 had spondylarthritis and 48 had RA. A total of 36.1% of the patients were smokers, and the most common comorbidity was hypertension (17.3%). Totally, 5.8% of the patients had a history of contact with a COVID-19 positive person. Only three (1.1%) patients were diagnosed with COVID-19 infection and none of them died. Of the patients, 64.3% continued their treatment, while 35.7% adopted various changes. Most patients made the decision about the treatment plan on their own (n=160, 57.8%), while 38.3% of them consulted their physicians and 13.9% of them consulted any health staff. The only significant parameter for changing the drug course was receiving intravenous bDMARDs (by infusion at hospital) (p=0.001). These patients had also a higher disease activity as measured by VAS, compared to the patients receiving non-infusion therapy (p=0.021). As a result of these changes, severity of the symptoms increased in 91 (32.9%) patients. Disruption of regular biological treatment and prior infusion therapy more likely worsened the complaints (p<0.001 and p=0.024, respectively).Conclusion: Intravenous bDMARD therapy seems to be the main factor affecting the continuity of the treatment in the pandemic period. During the pandemic period, alternative treatment options should be considered other than infusion therapy not to interrupt the treatment of these patients.Publication Central sensitisation in primary Sjogren Syndrome and its effect on sleep quality(Oxford Univ Press, 2021-09-23) Ökmen, Burcu Metin; Ayar, Koray; Altan, Lale; Yeşilöz, Özgür; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı; AAH-1652-2021Objective The aim of the present study is to evaluate the presence and frequency of central sensitisation (CS) in primary Sjogren Syndrome (pSS) and to determine the effect of CS on sleep quality. Materials and Methods In this cross-sectional study, 50 patients diagnosed with pSS between the ages of 18 and 75 were included. The healthy control group was composed of 43 healthcare workers. Each participant underwent a physical examination, and demographic data and the medications they used were recorded. Central sensitisation inventory and Pittsburgh Sleep Quality Index questionnaires were filled in to garner data on CS and sleep quality, respectively, from all participants. Results While central sensitisation inventory >40 was detected in 74% of pSS patients, it was 25.6% in healthy controls, and there is a statistically significant difference between the groups (p < .05). A correlation analysis of the central sensitisation inventory and Pittsburgh Sleep Quality Index values of all participants revealed a statistically significant correlation between all parameters other than the duration of sleep (p < .05). Conclusions CS was found to have a negative effect on sleep quality in patients with pSS. We suggest that the cause of widespread pain seen in patients with pSS as the possible development of CS should be considered.Publication Serum progranulin levels in axial spondyloarthropathy and relationship with clinical features(Turkish League Against Rheumatism, 2021-10-16) Dogangun, Didem Ildemir; Aksoy, Meliha Kasapoglu; Altan, Lale; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-4688-0464Objectives: In this study, we aimed to investigate the serum progranulin (PGRN) levels in patients with axial spondyloarthropathy (AxSpA) and to identify the correlation between disease activity, symptom severity, acute phase reactant (APR), and serum PGNR levels in patients with AxSpA. Patients and methods: This prospective, cross-sectional study included a total of 152 patients (105 males, 47 females; mean age: 41.8 +/- 10.3; range 20 to 65 years) with AxSpA according to the 2009 Assessment of SpondyloArthritis Society (ASAS) criteria who received treatment and 100 healthy individuals (61 males, 39 females; mean age 43.4 +/- 14.2; range 20 to 65 years) between February 2018 and February 2019. Serum PGRN levels from the venous blood were analyzed in both groups. The clinical AxSpA assessment scales were used in the patient group. Erythrocyte sedimentation rate and C-reactive protein levels were examined. Results: The mean serum PGRN level was 6.9 +/- 5.4 ng/mL in the patient group and 11.2 +/- 6.0 ng/mL in the control group. Serum PGRN level was significantly higher in the control group (p<0.001). No significant correlation was found between the PGRN levels and disease activity, symptom severity, duration of disease, and age of the patient (p>0.05). Serum PGRN levels were significantly higher in female patients in the patient group (p<0.01). In the control group, the serum PGRN levels of individuals with a high body mass index were significantly higher (p=0.001). Conclusion: Serum PGRN levels of patients with AxSpA who are under treatment and follow-up are significantly lower than healthy individuals. Serum PGRN levels in female patients with AxSpA are also significantly higher than male patients. Serum PGRN levels do not seem to be related to disease activity.Publication Evaluation of disease burden, unmet treatment and management needs of patients with hip and knee osteoarthritis: Consensus statements from a delphi-method panel in Turkey(Springer London, 2021-12-01) Cay, H. F.; Tuncer, T.; Akinci, A.; Ataman, S.; Aydogdu, S.; Diracoglu, D.; Genc, H.; Hepguler, S.; Ketenci, A.; Ones, K.; Uyar, M.; Olmez, A.; Gumru, S.; Altan, L.; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizik Tedavi ve Rehabilitasyon Anabilim Dalı.; 0000-0003-3570-3825; HIK-2784-2022; ABN-7109-2022Publication Investigation of the effect of kinesiotaping on the respiratory function and depression in male patients with chronic obstructive pulmonary disease: A prospective, randomized, controlled, and single-blind study(Taylor & Francis, 2020-04-09) Ökmen, Burcu Metin; Dikiş, Özlem Şengören; Ökmen, Korgun; Altan, Lale; Yıldız, Tekin; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; 0000-0002-6453-8382; AAH-1652-2021ObjectivesWe aimed to investigate the effect of kinesiotaping (KT) on the respiratory parameters as measured by spirometry and depression in the chronic obstructive pulmonary disease (COPD) patients.MethodsIn this prospective, randomized, controlled, single-blind study 42 male patients with COPD diagnosis were randomized into two groups. In Group1 (n = 21) routine COPD medical treatment plus kinesiotaping and in Group2 (n = 21) only routine COPD medical treatment was given. KT was changed on every fifth day (for a total of three times and 15 days). The patients were assessed using Visual Analog Scale (VAS) for difficulty experienced by the patients during respiration, respiratory function test (RFT), modified medical research council (mMRC) dyspnea scale and beck depression inventory (BDI). The data were obtained before treatment and posttreatment.ResultsIn Group 1; statistically significant improvement was found in all parameters except for FVC and FVC % following treatment compared to pretreatment values. Comparison of the difference scores (the amount of recovery between posttreatment and pretreatment) of the two groups showed significantly superior improvement in Group1 for all parameters except for FVC, FVC % and FEV1% following the treatment (p < .05).ConclusionsThe results of this study showed that supplementary kinesiotaping improved respiratory function and depression significantly compared to only routine medical treatment in COPD patients who were in stable condition.Publication The efficacy of transcutaneous electrical nerve stimulation therapy in pain control after cesarean section delivery associated with uterine contractions and abdominal incision(Bayçınar Medikal Yayın, 2020-01-01) Kasapoğlu, Işıl; Aksoy, Meliha Kasapoğlu; Demir, Bilge Çetinkaya; Altan, Lale; KASAPOĞLU, IŞIL; ÇETİNKAYA DEMİR, BİLGE; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı; 0000-0002-6453-8382; 0000-0001-6845-9991; 0000-0002-1953-2475; AAH-9834-2021; AAH-1652-2021; CXJ-7203-2022Objectives: This study aims to investigate the effects of transcutaneous electrical nerve stimulation ( TENS) therapy on the intensity of pain associated with uterine contractions and abdominal incision in patients undergoing cesarean section (C-section) delivery.Patients and methods: This single-blind, prospective, randomized-controlled study included a total of 90 female patients (mean age 30.5 years; range, 25 to 36 years) who had a scheduled C- section delivery between November 2017 and April 2018. Forty-five postpartum patients were randomly assigned into the treatment group (Group 1) and TENS electrodes were placed below and above the abdominal incision. The control group (n=45) consisted of 45 patients who had a scheduled C- section (Group 2) (n=45) and received routine follow-up care. The Visual Numeric Scale (VNS) scores were obtained separately for abdominal, low back, and groin pain at baseline (within 1 h after C-section before the TENS replacement), at postpartum 2, 6, 24, and 48 h. In addition to instant scoring, the percentages of change in pain scores from baseline were also calculated for each time points.Results: Data of a total of 87 patients were analyzed. No statistically significant difference was found in the baseline VNS scores measured in any body regions between the groups (p>0.05). However, there was a statistically significant difference in the instant VNS scores for abdominal pain at 2, 6, 24, and 48 h in favor of Group 1 (p<0.05). No significant differences were found in the instant VNS scores for low back and groin pain (p>0.05). The comparison of changes in pain scores from baseline (% change) over time between the groups revealed a statistically significant difference in favor of Group 1 in all VNS scores for abdominal, low back, and groin pain at 2, 6, 24, and 48 h (p<0.05).Conclusion: Our study results suggest that TENS is an effective and safe non-invasive, non-pharmacological treatment modality. It may be preferred as an alternative method in pain control in postpartum women after C-section delivery.Publication Central sensitization and its relationship with health profile in behcet's disease(Taylor, 2020-07-03) Ayar, Koray; Ökmen, Burcu M.; Altan, Lale; Öztürk, Esra K.; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı; AAH-1652-2021Objectives:In this study, we aimed to evaluate the level of central sensitization (CS) and its relationship with health profile, including neuropathic pain and sleep quality in Behcet's disease (BD). Method:Eighty-eight patients with BD and 60 healthy controls (HCs) were included in the study between May 2018 and February 2019. Nottingham health profile (NHP), pain DETECT, Pittsburgh sleep quality index (PSQI) questionnaires and the central sensitization inventory (CSI) were administered to all participants. To evaluate the correlations of the NHP, PSQI, and PDQ scores with the CSI score, the CSI was modified for each questionnaire. The activity of BD was determined by the Behcet's disease current activity form (BDCAF). Results:CSI scores were significantly higher in patients with BD than HCs (BD: 41.2 +/- 21.1 vs HCs: 20.4 +/- 16.9,p < .001). Clinical CS was detected in 69.3% of patients with BD and 28.3% of HCs (p < .001). Severe or extreme CS (CSI score >= 50) was present in 37.5% of patients with BD and 5.0% of HCs (p < .001). There were high correlations between the modified CSI scores and the NHP, PDQ and PSQI scores in patients with BD (R = 0.804;p < .001, Rho = 0.698;p < .001, and Rho = 0.734;p < .001, respectively). There was significant correlation between CSI and BDCAF scores (Rho= 0.470,p < .001). Conclusion:CS is more frequent and more severe in patients with BD than in HCs. There is a strong correlation between the severity of CS and poor health profile in patients with BD.Publication Assessment of knee osteoarthritis by ultrasonography and its association with knee pain(IOS Press, 2020-01-01) Kandemirli, Güzin Çakır; Başaran, Murat; Kandemirli, Sedat; İnceoğlu, Lale Altan; Kandemirli, Güzin Çakır; Kandemirli, Sedat; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; CXO-0560-2022 ; A-1409-2017; CVV-9193-2022BACKGROUND: Pain is a significant cause of disability in knee osteoarthritis. Conventional radiography is widely used in the assessment of knee osteoarthritis, however radiographic findings do not correlate well with pain. Ultrasonography can be used to evaluate the soft tissue structures of the knee that can be related to pain.OBJECTIVE: To evaluate pain-related soft tissue structures of the knee with ultrasonography.METHODS: This cross-sectional study included a total of 198 knees from 99 patients with knee osteoarthritis. Knee pain and functional status were evaluated by performing visual analogue scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). On the ultrasound, cartilaginous thickness, knee effusion and presence of Baker's cyst were assessed and the correlation to pain was investigated.RESULTS: Baker's cyst was significantly more frequent in symptomatic knees (13.9%) compared to asymptomatic knees (2.5%). Patients with Baker's cyst had a significantly more limited degree of knee flexion, significantly higher resting VAS pain scores and worse WOMAC scores compared to patients without Baker's cyst. In log-linear analysis, presence of Baker's cyst increased the risk of pain by 2.94 times.CONCLUSION: Ultrasound as a modality that is easily accessible, inexpensive and without radiation exposure is helpful to demonstrate factors related to pain in knee osteoarthritis by allowing assessment of soft tissue structures.Publication The effect of teriparatide treatment on the risk of clinical fragility fractures in postmenopausal women with osteoporosis: Results from the asian and latin america fracture observational study (alafos)(Wiley, 2020-11-01) Yang, Huilin; Al Ali, Nadia; Borges, Joao; Brnabic, Alan; Casas, Noemi; Chen, Chung-Hwan; Elsalmawy, Abdulaziz; Gürbüz, Sirel; Ish-Shalom, Sophia; Lim, Seung-Jae; Marin, Fernando; Moll, Thomas; Pavo, Imre; Florez, Sandra; Altan, Lale; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; AAH-1652-2021Publication The relationship between mri findings, pain and disability in the patients with cervical osteoarthritis(Springer, 2018-04-01) Altan, Lale; Ökmen, B. Metin; Tuncer, T.; Akarırmak, U.; Ayhan, F.; Bal, A.; Bozbaş, G.; Cerrahoğlu, L.; Çevik, R.; Durmaz, B.; Duruöz, T.; Dülgeroğlu, D.; Gürer, G.; Gürsoy, S.; Hepgüler, S.; Hizmetli, S.; Kaçar, C.; Kaptanoğlu, E.; Kocabaş, H.; Nas, K.; Nur, H.; Özçakır, Şuheda; Özdolap, S.; Sindel, D.; Şahin, O.; Sendur, F.; Tikiz, C.; Uğurlu, H.; ALTAN İNCEOĞLU, LALE; ÖZÇAKIR, ŞÜHEDA; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0003-0851-3620; AAH-1652-2021; AAH-5375-2021