Person: ALTAN İNCEOĞLU, LALE
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ALTAN İNCEOĞLU
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LALE
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Publication The relationship between CRP gene polymorphism (rs2794521, rs3091244), ASDAS-CRP and ASDAS-ESR in ankylosing spondylitis(Taylor, 2019-07-20) Aksoy, Meliha Kasapoğlu; Altan, Lale; Görükmez, Orhan; Güner, Altuğ; Ayar, Koray; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı; AAH-1652-2021Background: We aimed to investigate the haplotypes and alleles of two variants (rs2794521 and rs3091244) in AS patients and to examine their relationship with ASDAS-CRP and ASDAS-ESR values. Methods: We evaluated 160 AS patients diagnosed according to the ASAS criteria. ASDAS-CRP and ASDAS-ESR values were calculated. ESR and CRP were examined. The restriction fragment length polymorphism (RFLP) method was used for detecting the rs2794521 and rs3091244 regions on the CRP gene. Results: As a result of the evaluation of rs2794521 gene polymorphism using PCR, TT, TC and CC genotypes were observed in 90, 81 and 9 individuals, respectively. As a result of the evaluation of rs3091244 gene polymorphism, CC, AC and TT genotypes were observed in 104, 51 and 5 individuals, respectively. T allele and C allele were found in rs2794521 gene by 75% and 25%, respectively. In addition, T allele, C allele and A allele were found in rs3091244 gene by 80%, 17% and 3%, respectively. With the help of regression equation, ASDAS-CRP level was 0.34 units higher in cases with rs3091244 C allele than cases without rs3091244 C alleles. Conclusion: CRP rs3091244 C allele may be associated with the increased relative risk for ASDAS-CRP.Publication Turkish compliance and adaptation of EULAR 2013 recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: Expert opinion of TLAR(Turkish League Against Rheumatism, 2015-05-27) Ataman, Şebnem; Sürmeli, Zühre Sarı; Sunar, İsmihan; Özdemirel, Erhan; Akıncı, Ayşen; Bodur, Hatice; Akgul, Ozgur; Altan, Lale; Altay, Zuhal; Ayhan, Figen; Birtane, Murat; Soy Buğdaycı, Derya; Capkin, Erhan; Cerrahoglu, Lale; Duruoz, Mehmet Tuncay; Gunaydin, Rezzan; Gunendi, Zafer; Gurer, Gulcan; Bal, Ajda; Kacar, Cahit; Kaptanoglu, Ece; Kaya, Taciser; Kocabas, Hilal; Kotevoglu, Nurdan; Nas, Kemal; Rezvani, Aylin; Sen, Nesrin; Sendur, Omer Faruk; Yalcin, Peyman; ALTAN İNCEOĞLU, LALE; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; AAH-1652-2021Objectives: This study aims to report Turkish League Against Rheumatism's assessment on the compliance of European League Against Rheumatism 2013 treatment recommendations for rheumatoid arthritis with practices in Turkish rheumatology clinics and adaptations for Turkey.Materials and methods: Members of Turkish League Against Rheumatism and one rheumatoid arthritis patient voted for the 2013 recommendations of the European League Against Rheumatism for treatment of rheumatoid arthritis in two sessions. An item was changed and voted again only if at least 70% of participants wanted a change. Strength of recommendations was calculated for the items. Strength of recommendations for the changed items in the first and second voting rounds was compared by Wilcoxon signed-rank test. In case of significant difference, the item with higher strength of recommendation was accepted. In case of no difference, the changed item was selected.Results: Three overarching principles and fourteen recommendations were assessed among which the three overarching principles were changed emphasizing the importance of physiatrists as well as rheumatologists for taking care of the patients. Third item was changed by adding composite indices for assessing disease activity. In the ninth recommendation, rituximab was suggested as a first line drug independent of situations like latent tuberculosis or lymphoma, etc. In the 11th recommendation, unlike European League Against Rheumatism, our committee did not suggest any thought about tofacitinib, as then it had not been approved in Turkey. Remaining principles were accepted as the same.Conclusion: Expert opinion of Turkish League Against Rheumatism for treatment of rheumatoid arthritis patients was formed for practices in Turkish clinics.Publication Serum progranulin levels in axial spondyloarthropathy and relationship with clinical features(Turkish League Against Rheumatism, 2021-10-16) Dogangun, Didem Ildemir; Aksoy, Meliha Kasapoglu; Altan, Lale; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-4688-0464Objectives: In this study, we aimed to investigate the serum progranulin (PGRN) levels in patients with axial spondyloarthropathy (AxSpA) and to identify the correlation between disease activity, symptom severity, acute phase reactant (APR), and serum PGNR levels in patients with AxSpA. Patients and methods: This prospective, cross-sectional study included a total of 152 patients (105 males, 47 females; mean age: 41.8 +/- 10.3; range 20 to 65 years) with AxSpA according to the 2009 Assessment of SpondyloArthritis Society (ASAS) criteria who received treatment and 100 healthy individuals (61 males, 39 females; mean age 43.4 +/- 14.2; range 20 to 65 years) between February 2018 and February 2019. Serum PGRN levels from the venous blood were analyzed in both groups. The clinical AxSpA assessment scales were used in the patient group. Erythrocyte sedimentation rate and C-reactive protein levels were examined. Results: The mean serum PGRN level was 6.9 +/- 5.4 ng/mL in the patient group and 11.2 +/- 6.0 ng/mL in the control group. Serum PGRN level was significantly higher in the control group (p<0.001). No significant correlation was found between the PGRN levels and disease activity, symptom severity, duration of disease, and age of the patient (p>0.05). Serum PGRN levels were significantly higher in female patients in the patient group (p<0.01). In the control group, the serum PGRN levels of individuals with a high body mass index were significantly higher (p=0.001). Conclusion: Serum PGRN levels of patients with AxSpA who are under treatment and follow-up are significantly lower than healthy individuals. Serum PGRN levels in female patients with AxSpA are also significantly higher than male patients. Serum PGRN levels do not seem to be related to disease activity.Publication Comparison of quantitative ultrasonography with dual energy absorptiometry and investigation of the correlation between quantitative ultrasonography parameters(Springer, 2004-04-01) Altan, Lale; Bingöl, Ü; Kumaş, F. F; Ercan, İlker; Yurtkuran, Merih; ALTAN İNCEOĞLU, LALE; Bingöl, Ü; Kumaş, F. F; ERCAN, İLKER; Yurtkuran, Merih; Uludağ Üniversitesi/Tıp Fakültesi/Atatürk Rehabilitasyon Merkezi; Uludağ Üniversitesi/Tıp Fakültesi//Biyostat Bölümü; AAH-1652-2021; EMT-7521-2022; FJP-3640-2022; EUN-5017-2022; EGT-2006-2022Publication Familial transient osteoporosis of the hip? On account of three cases from the same family(Aves, 2018-03-01) Karlıbel, Ilknur Aykurt; Aksoy, Meliha Kasapoğlu; Altan, Lale; ALTAN İNCEOĞLU, LALE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; 0000-0003-4688-0464; AAH-1652-2021Transient osteoporosis of the hip (TOH) is a rare clinical entity characterized by a spontaneous hip pain associated with a delayed appearance of osteoporosis in the femoral head. In this report, we present three members of the same family, who were diagnosed with TOH based on the radiological findings. In case 1. a 29-year-old, single, non-pregnant female presented with severe, increasing pain in the right hip with a diagnosis of TOH. In case 2. the patient is the father of the above-mentioned patient and presented with pain in the right hip at the age of 48 years. 9 years before the date when his daughter was diagnosed with TOH. In case 3. the patient is the uncle of the case 1 patient and brother of case 2 patient. He was referred to our outpatient clinic and was diagnosed with TOH 8 years before the admission of the case 1 patient. Our case 1 was an interesting case of TOH, considering the distinct features of this patient, who was a non-pregnant woman with migratory transient osteoporosis, as well as familial character of the condition when assessed in association with the other two cases. These findings suggest that genetic factors should be taken into consideration in the etiological assessment, and there is a requirement for gene studies for further clarification.Publication Risk of falls in patients with ankylosing spondylitis(BMJ Publishing Group, 2013-06-01) Dursun, N.; Sarıkaya, S.; Özdolap, S.; Dursun, E.; Zateri, C.; Altan, Lale; Birtane, M.; Akgün, K.; Revzani, A.; Aktaş, I.; Taştekin, N.; Çeliker, R.; ALTAN İNCEOĞLU, LALE; Uludağ Üniversitesi/Tıp Fakültesi; AAH-1652-2021Publication Ruptured baker's cycst mimicking the symptoms of deep vein thrombosis in a rheumatoid arthritis patient(Aves Yayıncılık, 2008-01-01) Demir, Demet Göçmen; Altan, Lale; Diraz, Nuray; Demir, Demet Göçmen; ALTAN İNCEOĞLU, LALE; Diraz, Nuray; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; AAH-1652-2021; ILF-6676-2023; CMX-8131-2022A 50-year-old male patient who had a diagnosis of rheumatoid arthritis was admitted to our clinic with the complaint of sudden onset of severe pain and swelling in his right knee and calf. An initial diagnosis of deep vein thrombosis was made, however, ultrasound imaging revealed bilateral popliteal Baker's cysts. The cyst on the right side was ruptured. Both of the cysts were aspirated. Concomitant occurrence of rheumatoid arthritis and Baker's cyst which could be confused with deep venous thrombosis was discussed in this case presentation.Publication The relationship between mri findings, pain and disability in the patients with cervical osteoarthritis(Springer, 2018-04-01) Altan, Lale; Ökmen, B. Metin; Tuncer, T.; Akarırmak, U.; Ayhan, F.; Bal, A.; Bozbaş, G.; Cerrahoğlu, L.; Çevik, R.; Durmaz, B.; Duruöz, T.; Dülgeroğlu, D.; Gürer, G.; Gürsoy, S.; Hepgüler, S.; Hizmetli, S.; Kaçar, C.; Kaptanoğlu, E.; Kocabaş, H.; Nas, K.; Nur, H.; Özçakır, Şuheda; Özdolap, S.; Sindel, D.; Şahin, O.; Sendur, F.; Tikiz, C.; Uğurlu, H.; ALTAN İNCEOĞLU, LALE; ÖZÇAKIR, ŞÜHEDA; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0003-0851-3620; AAH-1652-2021; AAH-5375-2021Publication Effects of pilates exercises on pain, functional status and quality of life in women with postmenopausal osteoporosis(Elsevier, 2013-04-01) Küçükçakır, Nurten; Altan, Lale; Korkmaz, Nimet; Küçükçakır, Nurten; ALTAN İNCEOĞLU, LALE; HAŞIL KORKMAZ, NİMET; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; Uludağ Üniversitesi/Eğitim Fakültesi/Beden Eğitimi ve Spor Bölümü.; ACC-2582-2022; AAH-1652-2021; DBI-7953-2022Objective: The present study aimed to evaluate the effects of Pilates exercise program on pain, functional status and quality of life in women with postmenopausal osteoporosis.Design: The study was performed as a randomized, prospective, controlled and single-blind trial.Participations: Seventy women (age range, 45-65 years) with the diagnosis of postmenopausal osteoporosis were included.Methods and interventions: Patients were randomly allocated into two groups (home and Pilates exercise groups). Patients in the Pilates exercise group underwent a supervised Pilates exercise program twice a week for one year. Patients in the home exercise group were asked to perform a home exercise program consisting of thoracic extension exercises. Patients were evaluated at baseline and after one year of participation in the exercise programs.Main outcome measurements: Visual Analog Scale for pain, six-minute walking and sit-to-stand tests for functional status, and the Qualeffo-41 Questionnaire and the Short Form-36 (SF-36) for quality of life. Patients were also asked to report the number of falls during the intervention.Results: At the end of the study, the results of 60 patients were analyzed. A significant improvement was noted in all evaluation parameters at the end of the exercise program in the Pilates exercise group. Except for Qualeffo-Leisure Time Activities, SF-36 physical role limitation and emotional role limitation subscales, a significant improvement was noted in all other evaluation parameters at the end of the exercise program in the home exercise group. Improvement was significantly greater in the Pilates exercise group compared to the home exercise group in all parameters.Conclusion: Pilates exercises may be a safe and an effective treatment alternative for the quality of life in patients with postmenopausal osteoporosis. (C) 2012 Elsevier Ltd. All rights reserved.Publication Attitudes of patients with spondylarthritis or rheumatoid arthritis regarding biological treatment during covid-19 pandemic: A multi-center, phone-based, cross-sectional study(Türkiye Romatizma Araştırma ve Savaş Derneği, 2021-12-01) Zateri, Coskun; Birtane, Murat; Aktaş, İlknur; Sarıkaya, Selda; Rezvani, Aylin; Altan, Lale; Dursun, Nigar; Dursun, Erbil; Taştekin, Nurettin; Çeliker, Reyhan; Özdolap, Şenay; Akgün, Kenan; ALTAN İNCEOĞLU, LALE; 0000-0002-7948-5383; 0000-0002-1050-9666; 0000-0002-8015-0513; 0000-0002-6552-7204; AAH-1652-2021Objectives: In this study, we aimed to investigate the medical treatment attitudes of patients with spondylarthritis or rheumatoid arthritis (RA) who were using biological drugs during the novel coronavirus-2019 (COVID-19) pandemic.Patients and methods: In this multi-center, cross-sectional study, a total of 277 patients (178 males, 99 females; median age: 45 years; range, 20 to 77 years) who were using biological disease-modifying anti-rheumatic drugs (bDMARDs) for rheumatic diseases and were reached by phone between June 1st, 2020 and June 30th, 2020 were included. Demographic characteristics, working status, type of the rheumatic disease, comorbidities, smoking habits, and type of the bDMARDs were recorded. Disease activity was evaluated using the Visual Analog Scale (VAS). The patients were asked whether they continued the treatment plan, as it was before or changed and, if changed, how they changed the plan and what happened after the change.Results: Of the patients, 229 had spondylarthritis and 48 had RA. A total of 36.1% of the patients were smokers, and the most common comorbidity was hypertension (17.3%). Totally, 5.8% of the patients had a history of contact with a COVID-19 positive person. Only three (1.1%) patients were diagnosed with COVID-19 infection and none of them died. Of the patients, 64.3% continued their treatment, while 35.7% adopted various changes. Most patients made the decision about the treatment plan on their own (n=160, 57.8%), while 38.3% of them consulted their physicians and 13.9% of them consulted any health staff. The only significant parameter for changing the drug course was receiving intravenous bDMARDs (by infusion at hospital) (p=0.001). These patients had also a higher disease activity as measured by VAS, compared to the patients receiving non-infusion therapy (p=0.021). As a result of these changes, severity of the symptoms increased in 91 (32.9%) patients. Disruption of regular biological treatment and prior infusion therapy more likely worsened the complaints (p<0.001 and p=0.024, respectively).Conclusion: Intravenous bDMARD therapy seems to be the main factor affecting the continuity of the treatment in the pandemic period. During the pandemic period, alternative treatment options should be considered other than infusion therapy not to interrupt the treatment of these patients.
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