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The role of centrally injected nesfatin-1 on cardiovascular regulation in normotensive and hypotensive rats

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dc.contributor.buuauthorYılmaz, Mustafa Sertaç
dc.contributor.buuauthorAltınbaş, Burçin
dc.contributor.buuauthorGüvenç, Gökçen
dc.contributor.buuauthorErkan, Leman Gizem
dc.contributor.buuauthorAvşar, Özge
dc.contributor.buuauthorSavcı, Vahide
dc.contributor.buuauthorKüçükşen, Duygu Udum
dc.contributor.buuauthorArıcan, İlker
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.orcid0000-0001-9496-1475tr_TR
dc.contributor.orcid0000-0002-9534-736Xtr_TR
dc.contributor.orcid0000-0002-1413-3651tr_TR
dc.contributor.orcid0000-0001-7052-1694tr_TR
dc.contributor.orcid0000-0001-6342-0094tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.researcheridAAH-1571-2021tr_TR
dc.contributor.researcheridAAR-6815-2021tr_TR
dc.contributor.researcheridAAH-5167-2021tr_TR
dc.contributor.researcheridAAG-7518-2021tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.scopusid8895544100tr_TR
dc.contributor.scopusid55356919300tr_TR
dc.contributor.scopusid56529426800tr_TR
dc.contributor.scopusid56529371200tr_TR
dc.contributor.scopusid56764150800tr_TR
dc.contributor.scopusid6603687024tr_TR
dc.contributor.scopusid56764576200tr_TR
dc.contributor.scopusid14055524200tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.date.accessioned2022-08-17T07:26:44Z
dc.date.available2022-08-17T07:26:44Z
dc.date.issued2015-12
dc.description.abstractThis study investigated the cardiovascular effects of nesfatin-1 in normotensive rats and animals subjected to hypotensive hemorrhage. Hemorrhagic hypotension was induced by withdrawal 2 mL blood/100 g body weight over a period of 10 min. Acute hemorrhage led to a severe and long-lasting decrease in mean arterial pressure (MAP) and heart rate (HR). Intracerebroventricularly (i.c.v.) administered nesfatin-1 (100 pmol) increased MAP in both normotensive and hemorrhaged rats. Nesfatin-1 also caused bradycardia in normotensive and tachycardia in hemorrhaged rats. Centrally injected nesfatin-1 (100 pmol, i.c.v.) also increased plasma catecholamine, vasopressin and renin concentrations in control animals and potentiated the rise in all three cardiovascular mediators produced by hemorrhage. These findings indicate that centrally administered nesfatin-1 causes a pressor response in conscious normotensive and hemorrhaged rats and suggest that enhanced sympathetic activity and elevated vasopressin and renin concentrations mediate the cardiovascular effects of the peptide.en_US
dc.identifier.citationYılmaz, M. S. (2015). "The role of centrally injected nesfatin-1 on cardiovascular regulation in normotensive and hypotensive rats". Autonomic Neuroscience: Basic and Clinical, 193, 63-68.en_US
dc.identifier.endpage68tr_TR
dc.identifier.issn1566-0702
dc.identifier.issn1872-7484
dc.identifier.pubmed26254710tr_TR
dc.identifier.scopus2-s2.0-84947491740tr_TR
dc.identifier.startpage63tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.autneu.2015.07.009
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1566070215300126
dc.identifier.urihttp://hdl.handle.net/11452/28221
dc.identifier.volume193tr_TR
dc.identifier.wos000366077800010
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.bapBAPtr_TR
dc.relation.journalAutonomic Neuroscience: Basic and Clinicalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitak1919B011302992tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectNesfatin-1en_US
dc.subjectMean arterial pressureen_US
dc.subjectHeart rateen_US
dc.subjectHemorrhagic shocken_US
dc.subjectCatecholamineen_US
dc.subjectVasopressinen_US
dc.subjectReninen_US
dc.subjectParaventricular nucleusen_US
dc.subjectBrainen_US
dc.subjectNeuroendocrineen_US
dc.subjectNeuronsen_US
dc.subject.emtreeCatecholamineen_US
dc.subject.emtreeNesfatin 1en_US
dc.subject.emtreeNeuropeptideen_US
dc.subject.emtreeReninen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeVasopressinen_US
dc.subject.emtreeCalcium binding proteinsen_US
dc.subject.emtreeCentral nervous system agentsen_US
dc.subject.emtreeDNA binding proteinsen_US
dc.subject.emtreeNerve proteinen_US
dc.subject.emtreeNucleobindinen_US
dc.subject.emtreeReninen_US
dc.subject.emtreeVasopressin derivativeen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBradycardiaen_US
dc.subject.emtreeCardiovascular effecten_US
dc.subject.emtreeCatecholamine blood levelen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeHemorrhagic hypotensionen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMean arterial pressureen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePressor responseen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeTachycardiaen_US
dc.subject.emtreeVasopressin blood levelen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBleedingen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeBlood pressureen_US
dc.subject.emtreeComplicationen_US
dc.subject.emtreeDisease modelen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeHypotensionen_US
dc.subject.emtreePathophysiologyen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeSprague Dawley raten_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood pressureen_US
dc.subject.meshBradycardiaen_US
dc.subject.meshCalcium-binding proteinsen_US
dc.subject.meshCatecholaminesen_US
dc.subject.meshCentral nervous system agentsen_US
dc.subject.meshDisease models, animalen_US
dc.subject.meshDNA-binding proteinsen_US
dc.subject.meshHeart rateen_US
dc.subject.meshHemorrhageen_US
dc.subject.meshHypotensionen_US
dc.subject.meshMaleen_US
dc.subject.meshNerve tissue proteinsen_US
dc.subject.meshRatsen_US
dc.subject.meshSprague-dawleyen_US
dc.subject.meshReninen_US
dc.subject.meshVasopressinsen_US
dc.subject.scopusNucleobindin; Pyroglutamyl-Histidyl-Glycine; DNA-Binding Proteinsen_US
dc.subject.wosNeurosciencesen_US
dc.titleThe role of centrally injected nesfatin-1 on cardiovascular regulation in normotensive and hypotensive ratsen_US
dc.typeArticle
dc.wos.quartileQ4en_US
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Farmakoloji Ana Bilim Dalıtr_TR
local.contributor.departmentVeterinerlik Fakültesi/Fizyoloji Ana Bilim Dalıtr_TR
local.contributor.departmentVeterinerlik Fakültesi/Biyokimya Ana Bilim Dalıtr_TR
local.contributor.departmentVeterinerlik Fakültesi/Anatomi Ana Bilim Dalıtr_TR

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