Publication:
The role of centrally injected nesfatin-1 on cardiovascular regulation in normotensive and hypotensive rats

dc.contributor.buuauthorYılmaz, Mustafa Sertaç
dc.contributor.buuauthorAltınbaş, Burçin
dc.contributor.buuauthorGüvenç, Gökçen
dc.contributor.buuauthorErkan, Leman Gizem
dc.contributor.buuauthorAvşar, Özge
dc.contributor.buuauthorSavcı, Vahide
dc.contributor.buuauthorKüçükşen, Duygu Udum
dc.contributor.buuauthorArıcan, İlker
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentVeterinerlik Fakültesi
dc.contributor.departmentVeterinerlik Fakültesi
dc.contributor.departmentVeterinerlik Fakültesi
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.departmentTıbbi Farmakoloji Ana Bilim Dalı
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.departmentAnatomi Ana Bilim Dalı
dc.contributor.orcid0000-0001-9496-1475
dc.contributor.orcid0000-0002-9534-736X
dc.contributor.orcid0000-0002-1413-3651
dc.contributor.orcid0000-0001-7052-1694
dc.contributor.orcid0000-0001-6342-0094
dc.contributor.orcid0000-0002-5600-8162
dc.contributor.researcheridAAH-1571-2021
dc.contributor.researcheridAAR-6815-2021
dc.contributor.researcheridAAH-5167-2021
dc.contributor.researcheridAAG-7518-2021
dc.contributor.researcheridAAG-6956-2021
dc.contributor.scopusid8895544100
dc.contributor.scopusid55356919300
dc.contributor.scopusid56529426800
dc.contributor.scopusid56529371200
dc.contributor.scopusid56764150800
dc.contributor.scopusid6603687024
dc.contributor.scopusid56764576200
dc.contributor.scopusid14055524200
dc.contributor.scopusid57192959734
dc.date.accessioned2022-08-17T07:26:44Z
dc.date.available2022-08-17T07:26:44Z
dc.date.issued2015-12
dc.description.abstractThis study investigated the cardiovascular effects of nesfatin-1 in normotensive rats and animals subjected to hypotensive hemorrhage. Hemorrhagic hypotension was induced by withdrawal 2 mL blood/100 g body weight over a period of 10 min. Acute hemorrhage led to a severe and long-lasting decrease in mean arterial pressure (MAP) and heart rate (HR). Intracerebroventricularly (i.c.v.) administered nesfatin-1 (100 pmol) increased MAP in both normotensive and hemorrhaged rats. Nesfatin-1 also caused bradycardia in normotensive and tachycardia in hemorrhaged rats. Centrally injected nesfatin-1 (100 pmol, i.c.v.) also increased plasma catecholamine, vasopressin and renin concentrations in control animals and potentiated the rise in all three cardiovascular mediators produced by hemorrhage. These findings indicate that centrally administered nesfatin-1 causes a pressor response in conscious normotensive and hemorrhaged rats and suggest that enhanced sympathetic activity and elevated vasopressin and renin concentrations mediate the cardiovascular effects of the peptide.
dc.identifier.citationYılmaz, M. S. (2015). "The role of centrally injected nesfatin-1 on cardiovascular regulation in normotensive and hypotensive rats". Autonomic Neuroscience: Basic and Clinical, 193, 63-68.
dc.identifier.endpage68
dc.identifier.issn1566-0702
dc.identifier.issn1872-7484
dc.identifier.pubmed26254710
dc.identifier.scopus2-s2.0-84947491740
dc.identifier.startpage63
dc.identifier.urihttps://doi.org/10.1016/j.autneu.2015.07.009
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1566070215300126
dc.identifier.urihttp://hdl.handle.net/11452/28221
dc.identifier.volume193
dc.identifier.wos000366077800010
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.bapBAP
dc.relation.journalAutonomic Neuroscience: Basic and Clinical
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak1919B011302992
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeurosciences & neurology
dc.subjectNesfatin-1
dc.subjectMean arterial pressure
dc.subjectHeart rate
dc.subjectHemorrhagic shock
dc.subjectCatecholamine
dc.subjectVasopressin
dc.subjectRenin
dc.subjectParaventricular nucleus
dc.subjectBrain
dc.subjectNeuroendocrine
dc.subjectNeurons
dc.subject.emtreeCatecholamine
dc.subject.emtreeNesfatin 1
dc.subject.emtreeNeuropeptide
dc.subject.emtreeRenin
dc.subject.emtreeUnclassified drug
dc.subject.emtreeVasopressin
dc.subject.emtreeCalcium binding proteins
dc.subject.emtreeCentral nervous system agents
dc.subject.emtreeDNA binding proteins
dc.subject.emtreeNerve protein
dc.subject.emtreeNucleobindin
dc.subject.emtreeRenin
dc.subject.emtreeVasopressin derivative
dc.subject.emtreeAnimal experiment
dc.subject.emtreeArticle
dc.subject.emtreeBradycardia
dc.subject.emtreeCardiovascular effect
dc.subject.emtreeCatecholamine blood level
dc.subject.emtreeControlled study
dc.subject.emtreeHeart rate
dc.subject.emtreeHemorrhagic hypotension
dc.subject.emtreeMale
dc.subject.emtreeMean arterial pressure
dc.subject.emtreeNonhuman
dc.subject.emtreePressor response
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeTachycardia
dc.subject.emtreeVasopressin blood level
dc.subject.emtreeAnimal
dc.subject.emtreeBleeding
dc.subject.emtreeBlood
dc.subject.emtreeBlood pressure
dc.subject.emtreeComplication
dc.subject.emtreeDisease model
dc.subject.emtreeDrug effects
dc.subject.emtreeHypotension
dc.subject.emtreePathophysiology
dc.subject.emtreePhysiology
dc.subject.emtreeSprague Dawley rat
dc.subject.meshAnimals
dc.subject.meshBlood pressure
dc.subject.meshBradycardia
dc.subject.meshCalcium-binding proteins
dc.subject.meshCatecholamines
dc.subject.meshCentral nervous system agents
dc.subject.meshDisease models, animal
dc.subject.meshDNA-binding proteins
dc.subject.meshHeart rate
dc.subject.meshHemorrhage
dc.subject.meshHypotension
dc.subject.meshMale
dc.subject.meshNerve tissue proteins
dc.subject.meshRats
dc.subject.meshSprague-dawley
dc.subject.meshRenin
dc.subject.meshVasopressins
dc.subject.scopusNucleobindin; Pyroglutamyl-Histidyl-Glycine; DNA-Binding Proteins
dc.subject.wosNeurosciences
dc.titleThe role of centrally injected nesfatin-1 on cardiovascular regulation in normotensive and hypotensive rats
dc.typeArticle
dc.wos.quartileQ4
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Farmakoloji Ana Bilim Dalı
local.contributor.departmentVeterinerlik Fakültesi/Fizyoloji Ana Bilim Dalı
local.contributor.departmentVeterinerlik Fakültesi/Biyokimya Ana Bilim Dalı
local.contributor.departmentVeterinerlik Fakültesi/Anatomi Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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