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The role of centrally injected nesfatin-1 on cardiovascular regulation in normotensive and hypotensive rats

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Yılmaz, Mustafa Sertaç
Altınbaş, Burçin
Güvenç, Gökçen
Erkan, Leman Gizem
Avşar, Özge
Savcı, Vahide
Küçükşen, Duygu Udum
Arıcan, İlker
Yalçın, Murat

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Elsevier

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This study investigated the cardiovascular effects of nesfatin-1 in normotensive rats and animals subjected to hypotensive hemorrhage. Hemorrhagic hypotension was induced by withdrawal 2 mL blood/100 g body weight over a period of 10 min. Acute hemorrhage led to a severe and long-lasting decrease in mean arterial pressure (MAP) and heart rate (HR). Intracerebroventricularly (i.c.v.) administered nesfatin-1 (100 pmol) increased MAP in both normotensive and hemorrhaged rats. Nesfatin-1 also caused bradycardia in normotensive and tachycardia in hemorrhaged rats. Centrally injected nesfatin-1 (100 pmol, i.c.v.) also increased plasma catecholamine, vasopressin and renin concentrations in control animals and potentiated the rise in all three cardiovascular mediators produced by hemorrhage. These findings indicate that centrally administered nesfatin-1 causes a pressor response in conscious normotensive and hemorrhaged rats and suggest that enhanced sympathetic activity and elevated vasopressin and renin concentrations mediate the cardiovascular effects of the peptide.

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Neurosciences & neurology, Nesfatin-1, Mean arterial pressure, Heart rate, Hemorrhagic shock, Catecholamine, Vasopressin, Renin, Paraventricular nucleus, Brain, Neuroendocrine, Neurons

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Yılmaz, M. S. (2015). "The role of centrally injected nesfatin-1 on cardiovascular regulation in normotensive and hypotensive rats". Autonomic Neuroscience: Basic and Clinical, 193, 63-68.

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