Publication:
Protective effects of Nigella sativa Oil in hyperoxia-induced lung injury

dc.contributor.authorTayman, Cüneyt
dc.contributor.authorÇekmez, Ferhat
dc.contributor.authorCanpolat, Fuat Emre
dc.contributor.authorÇetinkaya, Merih
dc.contributor.authorTonbul, Alparslan
dc.contributor.authorUysal, Sema
dc.contributor.authorTunç, Turan
dc.contributor.authorSarıcı, Serdar Ümit
dc.contributor.buuauthorKafa, İlker Mustafa
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentAnatomi Ana Bilim Dalı
dc.contributor.researcheridAAG-7125-2021
dc.contributor.scopusid8450193200
dc.date.accessioned2022-10-03T10:14:27Z
dc.date.available2022-10-03T10:14:27Z
dc.date.issued2013-01
dc.description.abstractBackground: Oxygen-induced lung injury is believed to lead to the development of bronchopulmonary dysplasia in premature infants. We have evaluated the beneficial effects of Nigella sativa oil (NSO) on rats with hyperoxia-induced lung injury. Methods: Thirty newborn Sprague-Dawley rats were randomly divided into 3 groups as hyperoxia (95% O-2), hyperoxia + NSO and control (21% O-2). Pups in the hyperoxia + NSO group were administered intraperitoneal NSO at a dose of 4 ml/kg daily during the study period. Histopathologic, immunochemical, and biochemical evaluations (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], malonaldehyde [MDA] and myeloperoxidase [MPO]) were performed. Results: In the histopathologic and immunochemical evaluation, severity of lung damage was significantly lower in the hyperoxia + NOS group (P<.05). Tissue GSH-Px and SOD levels were significantly preserved, and MDA, MPO levels were significantly lower in the hyperoxia + NSO group (P<.05). Conclusion: NSO significantly reduced the severity of lung damage due to hyperoxia.
dc.identifier.citationTayman, C. vd. (2013). "Protective effects of Nigella sativa Oil in hyperoxia-induced lung injury". Archivos de Bronconeumologia, 49(1), 15-21.
dc.identifier.endpage21
dc.identifier.issn0300-2896
dc.identifier.issn1579-2129
dc.identifier.issue1
dc.identifier.pubmed22592006
dc.identifier.scopus2-s2.0-84871720352
dc.identifier.startpage15
dc.identifier.urihttps://doi.org/10.1016/j.arbres.2012.03.013
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/22592006/
dc.identifier.urihttp://hdl.handle.net/11452/28926
dc.identifier.volume49
dc.identifier.wos000313859300003
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt içi
dc.relation.journalArchivos de Bronconeumologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRespiratory system
dc.subjectBronchopulmonary dysplasia
dc.subjectOxygen-induced lung injury
dc.subjectPreterm infants
dc.subjectNigella sativa oil
dc.subjectProtection
dc.subjectRat
dc.subjectOxygen
dc.subjectAntioxidants
dc.subjectInflammation
dc.subjectElastase
dc.subjectDamage
dc.subjectRats
dc.subject.emtreeGlutathione peroxidase
dc.subject.emtreeMalonaldehyde
dc.subject.emtreeMyeloperoxidase
dc.subject.emtreeNigella sativa oil
dc.subject.emtreeSuperoxide dismutase
dc.subject.emtreeUnclassified drug
dc.subject.emtreeVegetable oil
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeBiochemical composition
dc.subject.emtreeBlack cumin
dc.subject.emtreeControlled study
dc.subject.emtreeDisease severity
dc.subject.emtreeDrug effect
dc.subject.emtreeHistopathology
dc.subject.emtreeHyperoxia
dc.subject.emtreeImmunochemistry
dc.subject.emtreeLung injury
dc.subject.emtreeNewborn
dc.subject.emtreeNonhuman
dc.subject.emtreeRat
dc.subject.scopusThymoquinone; Nigella Sativa; Antioxidant
dc.subject.wosRespiratory system
dc.titleProtective effects of Nigella sativa Oil in hyperoxia-induced lung injury
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Anatomi Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: