Publication: Protective effects of Nigella sativa Oil in hyperoxia-induced lung injury
Date
Authors
Kafa, İlker Mustafa
Authors
Tayman, Cüneyt
Çekmez, Ferhat
Canpolat, Fuat Emre
Çetinkaya, Merih
Tonbul, Alparslan
Uysal, Sema
Tunç, Turan
Sarıcı, Serdar Ümit
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Elsevier
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Abstract
Background: Oxygen-induced lung injury is believed to lead to the development of bronchopulmonary dysplasia in premature infants. We have evaluated the beneficial effects of Nigella sativa oil (NSO) on rats with hyperoxia-induced lung injury.
Methods: Thirty newborn Sprague-Dawley rats were randomly divided into 3 groups as hyperoxia (95% O-2), hyperoxia + NSO and control (21% O-2). Pups in the hyperoxia + NSO group were administered intraperitoneal NSO at a dose of 4 ml/kg daily during the study period. Histopathologic, immunochemical, and biochemical evaluations (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], malonaldehyde [MDA] and myeloperoxidase [MPO]) were performed.
Results: In the histopathologic and immunochemical evaluation, severity of lung damage was significantly lower in the hyperoxia + NOS group (P<.05). Tissue GSH-Px and SOD levels were significantly preserved, and MDA, MPO levels were significantly lower in the hyperoxia + NSO group (P<.05).
Conclusion: NSO significantly reduced the severity of lung damage due to hyperoxia.
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Keywords
Respiratory system, Bronchopulmonary dysplasia, Oxygen-induced lung injury, Preterm infants, Nigella sativa oil, Protection, Rat, Oxygen, Antioxidants, Inflammation, Elastase, Damage, Rats
Citation
Tayman, C. vd. (2013). "Protective effects of Nigella sativa Oil in hyperoxia-induced lung injury". Archivos de Bronconeumologia, 49(1), 15-21.