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Effect of asbestos exposure on the frequency of egfr mutations and alk/ros1 rearrangements in patients with lung adenocarcinoma a multicentric study

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Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.

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Anaplastic lymphoma kinase, Factor receptor-mutations, Targeted therapy, Cancer, Association, Smoking, Classification, Epidemiology, Expression, Society, Alk, Asbestos, Egfr, Genetic alterations, Lung adenocarcinoma, Ros1, Science & technology, Life sciences & biomedicine, Public, environmental & occupational health, Public, environmental & occupational health

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