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Radioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro

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dc.contributor.authorZorlu, Tolga
dc.contributor.buuauthorÇinkılıç, Nilüfer
dc.contributor.buuauthorÇetintaş, Sibel Kahraman
dc.contributor.buuauthorVatan, Özgür
dc.contributor.buuauthorYılmaz, Dilek
dc.contributor.buuauthorÇavaş, Tolga
dc.contributor.buuauthorTunç, Sema
dc.contributor.buuauthorÖzkan, Lütfi
dc.contributor.buuauthorBilaloǧlu, Rahmi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji Ana Bilim Dalı
dc.contributor.departmentRadyasyon Onkolojisi Ana Bilim Dalı
dc.contributor.orcid0000-0002-3595-6286
dc.contributor.orcid0000-0002-7687-3284
dc.contributor.researcheridAAH-3508-2021
dc.contributor.researcheridAAH-5296-2021
dc.contributor.researcheridO-7508-2015
dc.contributor.researcheridAAA-7047-2020
dc.contributor.scopusid26533892300
dc.contributor.scopusid6505881756
dc.contributor.scopusid16235098100
dc.contributor.scopusid6701369462
dc.contributor.scopusid6602989548
dc.contributor.scopusid55557323500
dc.contributor.scopusid55915679400
dc.contributor.scopusid6505804122
dc.date.accessioned2022-11-10T08:38:41Z
dc.date.available2022-11-10T08:38:41Z
dc.date.issued2013-03
dc.description.abstractThe present study was designed to determine the radioprotective effect of two phytochemicals, namely, quinic acid and chlorogenic acid, against X-ray irradiation-induced genomic instability in non-tumorigenic human blood lymphocytes. The protective ability of two phenolic acids against radiation-induced DNA damage was assessed using the alkaline comet assay in human blood lymphocytes isolated from two healthy human donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for irradiation. The results of the alkaline comet assay revealed that quinic acid and chlorogenic acid decreased the DNA damage induced by X-ray irradiation and provided a significant radioprotective effect. Quinic acid decreased the presence of irradiation-induced DNA damage by 5.99-53.57% and chlorogenic acid by 4.49-48.15%, as determined by the alkaline comet assay. The results show that quinic acid and chlorogenic acid may act as radioprotective compounds. Future studies should focus on determining the mechanism by which these phenolic acids provide radioprotection.
dc.identifier.citationÇinkılıç, N. vd. (2013). "Radioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro". Food and Chemical Toxicology, 53, 359-363.
dc.identifier.endpage363
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pubmed23266271
dc.identifier.scopus2-s2.0-84872392997
dc.identifier.startpage359
dc.identifier.urihttps://doi.org/10.1016/j.fct.2012.12.008
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0278691512008782
dc.identifier.urihttp://hdl.handle.net/11452/29448
dc.identifier.volume53
dc.identifier.wos000322924700049
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.publisherPergamon-Elsevier Science
dc.relation.bapF (U)-2009/39
dc.relation.collaborationYurt içi
dc.relation.journalFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFood science & technology
dc.subjectToxicology
dc.subjectRadioprotection
dc.subjectChlorogenic acid
dc.subjectQuinic acid
dc.subjectX-ray irradiation
dc.subjectComet assay
dc.subjectDNA damage
dc.subjectCultured human-lymphocytes
dc.subjectGamma-radiation
dc.subjectCaffeic acid
dc.subjectLipid-peroxidation
dc.subjectAntioxidant activities
dc.subjectDerivatives
dc.subjectCells
dc.subjectCarcinogenesis
dc.subjectFlavonoids
dc.subjectMechanism
dc.subject.emtreeChlorogenic acid
dc.subject.emtreeQuinic acid
dc.subject.emtreeArticle
dc.subject.emtreeCell protection
dc.subject.emtreeComet assay
dc.subject.emtreeControlled study
dc.subject.emtreeDNA damage
dc.subject.emtreeGenomic instability
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeIn vitro study
dc.subject.emtreeLymphocyte
dc.subject.emtreeNormal human
dc.subject.emtreeRadiation protection
dc.subject.emtreeX ray
dc.subject.meshAdult
dc.subject.meshChlorogenic acid
dc.subject.meshComet assay
dc.subject.meshDNA damage
dc.subject.meshDose-response relationship, drug
dc.subject.meshDose-response relationship, radiation
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymphocytes
dc.subject.meshMale
dc.subject.meshQuinic acid
dc.subject.meshRadiation-protective agents
dc.subject.meshX-rays
dc.subject.meshYoung adult
dc.subject.scopusAntioxidant; Carlina Oxide; Lonicera
dc.subject.wosFood science & technology
dc.subject.wosToxicology
dc.titleRadioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro
dc.typeArticle
dc.wos.quartileQ1 (Food science & technology)
dc.wos.quartileQ2 (Toxicology)
dc.wos.quartileQ1
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Radyasyon Onkolojisi Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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