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Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators

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dc.contributor.authorBridoux, Alexandre
dc.contributor.authorCui, Huadong
dc.contributor.authorDyskin, Evgeny
dc.contributor.authorSchmitzer, Andreea Ruxandra
dc.contributor.authorMousa, Shaker A.
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentVeterinerlik Fakültesi
dc.contributor.departmentTemel Bilimler Bölümü
dc.contributor.orcid0000-0002-5600-8162
dc.contributor.researcheridAAG-6956-2021
dc.contributor.scopusid57192959734
dc.date.accessioned2022-07-07T10:23:21Z
dc.date.available2022-07-07T10:23:21Z
dc.date.issued2010-06-01
dc.description.abstractNovel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.
dc.description.sponsorshipCharitable Leadership Foundation
dc.description.sponsorshipMedical Technology Acceleration Program
dc.description.sponsorshipPharmaceutical Research Institute
dc.identifier.citationBridoux, A. vd. (2010). "Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators". Bioorganic and Medicinal Chemistry Letters, 20(11), 3394-3398.
dc.identifier.endpage3398
dc.identifier.issn0960-894X
dc.identifier.issn1464-3405
dc.identifier.issue11
dc.identifier.pubmed20434332
dc.identifier.scopus2-s2.0-77953293160
dc.identifier.startpage3394
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2010.04.011
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0960894X10004713
dc.identifier.urihttp://hdl.handle.net/11452/27789
dc.identifier.volume20
dc.identifier.wos000277788900043
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherPergamon-Elsevier Science
dc.relation.collaborationYurt dışı
dc.relation.journalBioorganic and Medicinal Chemistry Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectThyroxine
dc.subjectEsterification
dc.subjectSilylation
dc.subjectUV-vis
dc.subjectAngiogenesis
dc.subjectNanopharmaceutical technology
dc.subjectExtracelluler segment
dc.subjectCrystal-structure
dc.subjectThyhroid-hormone
dc.subjectForce-field
dc.subjectProteins
dc.subjectPharmacology & pharmacy
dc.subjectChemistry
dc.subject.emtreeAmino acid
dc.subject.emtreeAngiogenesis inhibitor
dc.subject.emtreeMatrigel
dc.subject.emtreeThyroxine derivative
dc.subject.emtreeAngiogenesis
dc.subject.emtreeAnimal experiment
dc.subject.emtreeArticle
dc.subject.emtreeChick
dc.subject.emtreeChorioallantois
dc.subject.emtreeControlled study
dc.subject.emtreeDrug activity
dc.subject.emtreeDrug effect
dc.subject.emtreeDrug synthesis
dc.subject.emtreeDrug tolerability
dc.subject.emtreeMouse
dc.subject.emtreeNonhuman
dc.subject.meshAngiogenesis inhibitors
dc.subject.meshAnimals
dc.subject.meshChick embryo
dc.subject.meshMice
dc.subject.meshModels, molecular
dc.subject.meshThyroxine
dc.subject.scopusTetraiodothyroacetic Acid; Thyroid Hormones; Nano-Diamino-Tetrac
dc.subject.wosChemistry, medicinal
dc.subject.wosChemistry, organic
dc.titleSemisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentVeterinerlik Fakültesi/Temel Bilimler Bölümü
local.indexed.atPubMed
local.indexed.atWOS

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