Publication:
Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators

Placeholder

Organizational Units

Authors

Yalçın, Murat

Authors

Bridoux, Alexandre
Cui, Huadong
Dyskin, Evgeny
Schmitzer, Andreea Ruxandra
Mousa, Shaker A.

Advisor

Language

Publisher:

Pergamon-Elsevier Science

Journal Title

Journal ISSN

Volume Title

Abstract

Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.

Description

Source:

Keywords:

Keywords

Thyroxine, Esterification, Silylation, UV-vis, Angiogenesis, Nanopharmaceutical technology, Extracelluler segment, Crystal-structure, Thyhroid-hormone, Force-field, Proteins, Pharmacology & pharmacy, Chemistry

Citation

Bridoux, A. vd. (2010). "Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators". Bioorganic and Medicinal Chemistry Letters, 20(11), 3394-3398.

Endorsement

Review

Supplemented By

Referenced By

0

Views

0

Downloads