Publication: Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators
Date
Authors
Yalçın, Murat
Authors
Bridoux, Alexandre
Cui, Huadong
Dyskin, Evgeny
Schmitzer, Andreea Ruxandra
Mousa, Shaker A.
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Pergamon-Elsevier Science
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Abstract
Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.
Description
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Keywords
Thyroxine, Esterification, Silylation, UV-vis, Angiogenesis, Nanopharmaceutical technology, Extracelluler segment, Crystal-structure, Thyhroid-hormone, Force-field, Proteins, Pharmacology & pharmacy, Chemistry
Citation
Bridoux, A. vd. (2010). "Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators". Bioorganic and Medicinal Chemistry Letters, 20(11), 3394-3398.