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Semisynthesis and pharmacological activities of tetrac analogs: Angiogenesis modulators

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Yalçın, Murat

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Bridoux, Alexandre
Cui, Huadong
Dyskin, Evgeny A.
Mousa, Shaker A.

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Pergamon-Elsevier Science

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Abstract

Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity.

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Keywords

Angiogenesis, Esterification, HPLC, Nanopharmaceutical technology, Silylation, Tetrac, Integrin alpha-v-beta-3, Extracellular segment, Crystal-structure, Triiodothyronine, Thyroxine, Ligand, Acid, Pharmacology & pharmacy, Chemistry

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Bridoux, A. vd. (2009). "Semisynthesis and pharmacological activities of tetrac analogs: Angiogenesis modulators". Bioorganic and Medicinal Chemistry Letters, 19(12), 3259-3263.

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