Publication: Oxidative stress and intracranial hypertension after aneurysmal subarachnoid hemorrhage
Date
Authors
Eser, Pınar
Authors
Hao, Guangshan
Mo, Jun
Advisor
Language
Type
Publisher:
Mdpi
Journal Title
Journal ISSN
Volume Title
Abstract
Intracranial hypertension is a common phenomenon in patients with aneurysmal subarachnoid hemorrhage (aSAH). Elevated intracranial pressure (ICP) plays an important role in early brain injuries and is associated with unfavorable outcomes. Despite advances in the management of aSAH, there is no consensus about the mechanisms involved in ICP increases after aSAH. Recently, a growing body of evidence suggests that oxidative stress (OS) may play a crucial role in physio-pathological changes following aSAH, which may also contribute to increased ICP. Herein, we discuss a potential relation between increased ICP and OS, and resultantly propose antioxidant mechanisms as a potential therapeutic strategy for the treatment of ICP elevation following aSAH.
Description
Source:
Keywords:
Keywords
Early brain-injury, Cerebral-blood-flow, Nitric-oxide synthase, Cerebrospinal-fluid, Intracerebral hemorrhage, Barrier disruption, Time-course, Pressure, Myeloperoxidase, Expression, Subarachnoid hemorrhage, Oxidative stress, Intracranial hypertension, Brain injury, Antioxidant, Science & technology, Life sciences & biomedicine, Biochemistry & molecular biology, Chemistry, medicinal, Food science & technology, Biochemistry & molecular biology, Pharmacology & pharmacy, Food science & technology