Publication: The beneficial effect of cyclosporin-A on the no-reflow phenomenon in rat skin island flaps
Date
Authors
Kücükçelebi, Ahmet
Özcan, M.
Authors
Advisor
Language
Type
Publisher:
Churchill Livingstone
Journal Title
Journal ISSN
Volume Title
Abstract
The no-reflow phenomenon is one of the factors that increase morbidity in flap and replantation surgery. Prevention and treatment of the phenomenon is an area of intense current research. This study investigated the possible effect of cyclosporin administered systemically on survival of skin flaps subjected to ischaemia-reperfusion injury. Cyclosporin treated flaps showed a statistically significant increase in survival areas regardless of the time of infusion (p < 0.01). These findings suggest that cyclosporin could be valuable in preventing or treating no-reflow in critical flaps. Possible mechanisms of action are discussed.
Description
Source:
Keywords:
Keywords
Liver, Surgery
Citation
Küçükçelebi, A. ve Özcan, M. (1992). ''The beneficial effect of cyclosporin-A on the no-reflow phenomenon in rat skin island flaps''. British Journal of Plastic Surgery, 45(7), 512-514.