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Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting

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dc.contributor.authorİşler, Burcu
dc.contributor.authorÖzer, Berna
dc.contributor.authorÇınar, Güle
dc.contributor.authorAslan, Abdullah Tarık
dc.contributor.authorVatansever, Cansel
dc.contributor.authorFalconer, Caitlin
dc.contributor.authorDolapçı, Istar
dc.contributor.authorŞimsek, Funda
dc.contributor.authorTülek, Necla
dc.contributor.authorDemirkaya, Hamiyet
dc.contributor.authorMenekşe, Şirin
dc.contributor.authorBalkan, İlker Inanç
dc.contributor.authorAydın, Mehtap
dc.contributor.authorTigen, Elif Tükenmez
dc.contributor.authorDemir, Safiye Koçulu
dc.contributor.authorKapmaz, Mahir
dc.contributor.authorKeske, Siran
dc.contributor.authorDoğan, Özlem
dc.contributor.authorArabacı, Ciğdem
dc.contributor.authorYagcı, Serap
dc.contributor.authorHazırolan, Gülşen
dc.contributor.authorBakir, Veli Oğuzalp
dc.contributor.authorGönen, Mehmet
dc.contributor.authorChatfield, Mark D.
dc.contributor.authorForde, Brian
dc.contributor.authorSaltoglu, Nese
dc.contributor.authorAzap, Alpay
dc.contributor.authorAzap, Özlem
dc.contributor.authorAkova, Murat
dc.contributor.authorPaterson, David L.
dc.contributor.authorCan, Füsun
dc.contributor.authorErgönül, Önder
dc.contributor.buuauthorAkalin, Halis
dc.contributor.buuauthorAKALIN, EMİN HALİS
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentMikrobiyoloji Ana Bilim Dalı
dc.contributor.researcheridAAU-8952-2020
dc.date.accessioned2024-12-02T05:38:23Z
dc.date.available2024-12-02T05:38:23Z
dc.date.issued2022-03-17
dc.description.abstractA prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.
dc.description.sponsorshipPfizer Global Medical Grants 56644459
dc.identifier.doi10.1007/s10096-022-04425-4
dc.identifier.endpage847
dc.identifier.issn0934-9723
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85126797654
dc.identifier.startpage841
dc.identifier.urihttps://doi.org/10.1007/s10096-022-04425-4
dc.identifier.urihttps://hdl.handle.net/11452/48738
dc.identifier.volume41
dc.identifier.wos000770200000001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer
dc.relation.journalEuropean Journal Of Clinical Microbiology & Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPneumoniae
dc.subjectOxa-232
dc.subjectEnterobacterales
dc.subjectCoproduction
dc.subjectSpread
dc.subjectNdm-1
dc.subjectOxa-48
dc.subjectOxa-232
dc.subjectSt2096
dc.subjectKlebsiella pneumoniae
dc.subjectCeftazidime-avibactam
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectInfectious diseases
dc.subjectMicrobiology
dc.subjectInfectious diseases
dc.titleCharacteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Mikrobiyoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus
relation.isAuthorOfPublication4fb46529-3295-4383-97b1-7c494ff32c24
relation.isAuthorOfPublication.latestForDiscovery4fb46529-3295-4383-97b1-7c494ff32c24

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