Publication: Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting
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Authors
Akalin, Halis
Authors
İşler, Burcu
Özer, Berna
Çınar, Güle
Aslan, Abdullah Tarık
Vatansever, Cansel
Falconer, Caitlin
Dolapçı, Istar
Şimsek, Funda
Tülek, Necla
Demirkaya, Hamiyet
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Springer
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Abstract
A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.
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Keywords
Pneumoniae, Oxa-232, Enterobacterales, Coproduction, Spread, Ndm-1, Oxa-48, Oxa-232, St2096, Klebsiella pneumoniae, Ceftazidime-avibactam, Science & technology, Life sciences & biomedicine, Infectious diseases, Microbiology, Infectious diseases