Yayın: Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting
Tarih
Kurum Yazarları
Akalin, Halis
Yazarlar
İşler, Burcu
Özer, Berna
Çınar, Güle
Aslan, Abdullah Tarık
Vatansever, Cansel
Falconer, Caitlin
Dolapçı, Istar
Şimsek, Funda
Tülek, Necla
Demirkaya, Hamiyet
Danışman
Dil
Türü
Yayıncı:
Springer
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Özet
A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.
Açıklama
Kaynak:
Anahtar Kelimeler:
Konusu
Pneumoniae, Oxa-232, Enterobacterales, Coproduction, Spread, Ndm-1, Oxa-48, Oxa-232, St2096, Klebsiella pneumoniae, Ceftazidime-avibactam, Science & technology, Life sciences & biomedicine, Infectious diseases, Microbiology, Infectious diseases