Publication: Impaired myocardial performance in sarcoidosis
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Authors
Kaderli, Aysel Aydın
GÜLLÜLÜ, NAZMİYE SÜMEYYE
Yılmaz, Dilber
Authors
Kaderli, Aysel Aydın
Güllülü, Sümeyye
Coşkun, Funda
Yılmaz, Dilber
Uzaslan, Esra
Advisor
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Turkish Assoc Tuberculosis & Thorax
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Abstract
Despite myocardial sarcoid involvement has been reported in 20-27% in autopsy series, only 5% of the patients are clinically symptomatic. This study was planned to evaluate right and left ventricular functions in patients with early stage sarcoidosis (stage I and II) without any findings of cardiac involvement with Tei index which globally shows systolic and diastolic functions of the ventricles was used. Seventy-two patients under follow-up for sarcoidosis without cardiac involvement (53 women, 19 men; mean age 49.1 +/- 10.3 years) and nineteen age-matched healthy control subjects (14 women, 5 men; mean age 48.7 +/- 6.5 years) were enrolled in the study. All subjects were evaluated with two-dimensional and Doppler echocardiography. Right and left ventricle Tei indices (myocardial performance index) were calculated from measured Doppler parameters. Peak velocity of the mitral A wave (A) was higher, peak velocity of the mitral E wave, E/A ratio were lower; and ejection time was shorter in patients with sarcoidosis (p< 0.05) compare to controls. Peak velocity of the tricuspid A wave was higher, E wave deceleration time was longer and E/A ratio was lower (p< 0.05) in sarcoidosis group. While left ventricular Tei index was higher in patients with sarcoidosis (p= 0.021), right ventricular Tei index was similar to healthy controls' (p> 0.05). Left ventricular myocardial performance is disturbed in patients with early stage sarcoidosis. This can be related to a subclinical involvement of sarcoidosis.
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Keywords
Sarcoidosis, Echocardiography, Tei index, Respiratory system