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Publication A case of a complete atrioventricular canal defect in a ferret(Bmc, 2021-01-22) Agudelo, Carlos F.; Jekl, Vladimir; Hauptman, Karel; Crha, Michal; Kocatürk, Meriç; KOCATÜRK, MERİÇ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0001-8320-1286; 0000-0002-2849-1222; V-5578-2017BackgroundAtrioventricular canal defect is a rare congenital disorder of the heart and describes the presence of an atrial septal defect, a variable presentation of ventricular septal alterations including ventricular septal defect malformations in the mitral and tricuspid valves. The defect has been described in human beings, dogs, cats, pigs, and horses.Case presentationThis paper describes the case of a complete atrioventricular canal defect in a four-year-old intact male pet ferret (Mustela putorius furo), which was presented due to posterior weakness, ataxia, and decreased appetite. A loud systolic murmur, dyspnea, and hind limb paraparesis were detected during the clinical examination. Thoracic radiographs showed generalized cardiomegaly and lung edema. ECG showed sinus rhythm with prolonged P waves and QRS complexes. Echocardiography showed a large atrial septal defect, atrioventricular dysplasia, and a ventricular septal defect. Palliative treatment with oxygen, furosemide, spironolactone, enalapril, diltiazem, and supportive care was chosen as the therapy of choice. The ferret recovered gradually during hospitalization. A follow-up examination at three and six months showed stabilization of cardiac function.ConclusionsTo the authors knowledge, this is the first time an atrioventricular canal defect has been described in a pet ferret.Publication A case report of primary breast angiosarcoma: Clinical presentation and outcome after adjuvant radiotherapy(Aves, 2020-10-01) Altmisdörtoğlu, Özgür; Andrieu, Meltem Nalca; Gökgöz, Mustafa Şehsuvar; GÖKGÖZ, MUSTAFA ŞEHSUVAR; Yalçınkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; AAH-8924-2021Angiosarcomas of the breast are infrequent subtypes of sarcoma that are often diagnosed after radiation therapy for primary breast cancer. Primary angiosarcomas (PAS) are rare tumors that constitute 0.04% of all malignant breast tumors. We report a case of a 40-year-old woman with a lump in the right breast and diagnosed as angiosarcoma by pathological evaluation. She underwent simple mastectomy followed by adjuvant radiation. She is alive and disease-free for 66 months although tumor size was large and one surgical margin was tumor positive. Breast angiosarcoma is often in advanced stage at diagnosis and tends to recur locally. Although surgical methods constitute the primary treatment, we believe that a multidisciplinary treatment strategy should be used in high-risk patients with large primary tumors and tumor positive margins.Publication A comparative study of recent non-traditional methods for mechanical design optimization (vol 27, pg 1031, 2020)(Springer, 2021-01-01) Yıldız, Ali Rıza; Abderazek, Hammoudi; Mirjalili, Seyedali; YILDIZ, ALİ RIZA; Bursa Uludağ Üniversitesi/Otomotiv Mühendisliği Bölümü; F-7426-2011Publication A comparative treatability study for textile wastewater: Agricultural waste adsorbent versus activated carbon(Hard, 2020-01-01) Kılıç, Melike Yalılı; YALILI KILIÇ, MELİKE; Bursa Uludağ Üniversitesi/Mühendislik Fakültesi/Çevre Mühendisliği Bölümü; 0000-0001-7050-6742; AAG-8505-2021This study aimed to remove color from textile wastewater taken from a common effluent channel in Bursa, western Turkey. For this purpose, chemical coagulation with various coagulants including Al-2(SO4)center dot 18H(2)O, FeCl3 center dot 6H(2)O and FeSO4 center dot 7H(2)O was applied, followed by adsorption processes. In the coagulation experiments, the maximum color removal efficiency (48%) was obtained at pH 6.5 with a 300 mg/L dose of Al-2(SO4)(3)center dot 18H(2)O. The adsorption experiments were conducted using 5 g each of agricultural waste adsorbent (corncob) particles with dimensions of 0.25 mm, 0.50 mm, 0.85 mm and 1.25 mm on the chemically treated wastewater samples, and color removal efficiencies of up to 100% were obtained. In addition, adsorption columns were designed according to the experimental data. As a result of the design calculations, 84 tons of the corncob are required to effectively remove color from 10,000 m(3) of textile wastewater. In addition to the color removal efficiencies of the applied processes, the associated operating costs were also calculated.Publication A government devoid of strong leadership: A neoclassical realist explanation of Turkey's Iraq War decision in 2003(Center Foreign Policy & Peace Research, 2021-07) Yılmaz, Samet; YILMAZ, SAMET; Bursa Uludağ Üniversitesi/Uluslararası İlişkiler Bölümü; 0000-0002-5232-5435; Q-5077-2016This study deals with Turkeys Iraq War Decision that led up to the March 1 Parliamentary Motion Crisis in 2003 from the perspective of neoclassical realism, which analyzes the interaction between systemic and unit-level variables. The United States requested Turkey's collaboration in the war against Iraq. The Justice and Development Party (AK Party) government initially sought a peaceful settlement hut eventually decided to align with the United States. Systemic and structural factors made cooperation with the United States an imperative for Turkey, which may be classified as a secondary state in the regional context. While the domestic political environment was favorable for the Turkish government to reach such a decision, it was hindered by the Grand National Assembly of 'Turkey (GNAT). In this framework the study has two primary purposes. The first is to prove that in restrictive international environments where opportunities and threats are clear and the decision-making process is constrained by time, domestic divisions may matter in foreign policy and prevail over the systemic imperative, contrary to conventional expectations. The second is to demonstrate that in a restrictive international milieu, strong leadership, a factor underappreciated by neoclassical realists, is essential even for single-party governments, which are normally expected to have greater autonomy in democratic parliamentary systems, to formulate foreign policy.Publication A homozygous synonymous variant likely cause of severe ciliopathy phenotype(MDPI, 2021-06-01) Tuncel, Gülten; Kaymakamzade, Bahar; Engindereli, Yeliz; Temel, Şehime Gülsün; Ergören, Mahmut Çerkez; TEMEL, ŞEHİME GÜLSÜN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Translasyonel Tıp Anabilim Dalı; 0000-0002-9802-0880; AAG-8385-2021Joubert syndrome (OMIM #213300) is a rare neurodevelopmental disease characterized by abnormal breathing patterns, intellectual impairment, ocular findings, renal cysts, and hepatic fibrosis. It is classified as a ciliopathy disease, where cilia function or structure in various organs are affected. Here, we report a 17-year-old male whose main clinical findings are oculomotor apraxia and truncal ataxia. Magnetic resonance imaging revealed the characteristic molar tooth sign of Joubert syndrome. He also has obsessive-compulsive disorder concomitantly, which is not a known feature of Joubert syndrome. Molecular genetic analysis revealed a homozygous c.2106G>A (p.(Thr702=)) variation in the Abelson helper integration 1 (AHI1) gene and another homozygous c.1739C>T (p.Thr580Ile) variation in the coiled-coil and C2 domain-containing protein 1A (CC2D1A) gene. Even though certain AHI1 variations were previously associated with Joubert syndrome (JS), c.2106G>A (p.(Thr702=)) was only reported in one patient in trans with another known pathogenic JS variant. The CC2D1A c.1739C>T (p.Thr580Ile) variation, on the other hand, has been reported to cause autosomal recessive nonsyndromic mental retardation, but there are conflicting interpretations about its pathogenicity. Overall, to our knowledge, this is the first patient representing a severe ciliopathy phenotype caused by a homozygous synonymous AHI1 variation. Further investigations should be performed to determine any involvement of the CC2D1A gene in ciliopathy phenotypes such as Joubert syndrome.Publication A laboratory study of the acaricidal, repellent and oviposition deterrent effects of three botanical oils on Tetranychus urticae (Koch, 1836) (Acari: Tetranychidae)(Ege Üniversitesi, 2020-04-25) Keskin, Gizem; Kumral, Nabi Alper; Kacar, Oya; Keskin, Gizem; KUMRAL, NABİ ALPER; KAÇAR, OYA; Bursa Uludağ Üniversitesi/Fen Bilimleri Enstitüsü/Entomoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Ziraat Fakültesi/Bitki Koruma Bölümü.; Bursa Uludağ Üniversitesi/Ziraat Fakültesi/Tarla Bitkileri Bölümü.; 0000-0001-9442-483X; A-1388-2019; AAG-7449-2021; KGA-9390-2024The biological activities of essential oil obtained from water distillation process of basil leaves [Ocimum basilicum L. (Lamiales: Lamiaceae)] cv Round Midnight and crude oil obtained from the cold-pressed process of chinaberry tree seeds [Melia azedarach L. (Sapindales: Meliaceae)] and a commercial neem oil product (Nimbecidine) [Azadirachta indica (A. Juss, 1830) (Sapindales: Meliaceae)] were assessed against two-spotted spider mites, Tetranychus urticae (Koch, 1836) (Atari: Tetranychidae) using a residual method on leaf disc under laboratory conditions at Bursa Uludag University during 2018-2019. The lethal concentrations (LC50 and LC90) of Nimbecidine, chinaberry and basil oils were estimated as 0.8 and 1.8 mg/L, 4.0 and 6.9%, 5.4 and 11.7%, respectively, 72 h after treatment. The lethal times (LT50 and LT90) of Nimbecidine (1 mg/L), chinaberry (6%) and the basil (8.4%) were 64 and 107 h, 41 and 73 h, 65 and 110 h, respectively. The females had a strong aversion to bean leaf surfaces sprayed with the sublethal concentrations of Nimbecidine (0.125-0.75 mg/L), chinaberry (0.75-3%) and basil (0.7-1.4%) oils. Significant decreases were recorded in the number of eggs laid on bean leaves sprayed with the sublethal concentrations for Nimbecidine (0.031-0.5 mg/L), chinaberry (0.75-3%) and the basil (1.4-5.6%) oils compared with unsprayed bean leaves. The study showed that the assessed concentrations of the oils obtained from the basil and chinaberry compared to the commercial botanical product (Nimbecidine) have similar biological effects on T. urticae.Publication A national, multicenter, secondary data use study evaluating efficacy and retention of first-line biologic treatment with tocilizumab in patients with rheumatoid arthritis in real-life setting from Turkbio registry(Bmj Publishing Group, 2021-06-01) Yazici, A.; Isik, O. Ozdemir; Koca, S. S.; Senel, S.; Inanc, N.; Akar, S.; Yilmaz, S.; Gunduz, O. Soysal; Cefle, A.; Onen, F.; Dalkilic, E.; DALKILIÇ, HÜSEYİN EDİZ; Pehlivan, Y.; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-2167-4509; 0000-0002-3835-466X; 0000-0002-3734-1242; 0000-0002-6341-2622; JBI-6627-2023; AAT-3636-2020; HTP-6798-2023; AAA-8970-2021; HJY-2666-2023; JDV-5142-2023Publication A new approach for battery thermal management system design based on grey relational analysis and latin hypercube sampling(Elsevier, 2021-09-16) Bulut, Emre; Albak, Emre İsa; Sevilgen, Gökhan; Öztürk, Ferruh; BULUT, EMRE; ALBAK, EMRE İSA; SEVİLGEN, GÖKHAN; ÖZTÜRK, FERRUH; Bursa Uludağ Üniversitesi/Mühendislik Fakültesi/Otomotiv Mühendisliği Bölümü; Bursa Uludağ Üniversitesi/Gemlik Asım Kocabıyık Meslek Yüksekokulu/Hibrit ve Elektrikli Araç Teknolojisi; 0000-0001-9159-5000; 0000-0001-9215-0775; 0000-0002-7746-2014; ABG-3444-2020; AAG-8907-2021; I-9483-2017; JCO-2416-2023; FRD-1816-2022A liquid cooling system is an effective type of battery cooling system on which many studies are presented nowadays. In this research, the effects of the mass flow rate and number of channels on the maximum temperature and pressure drop are investigated for multi-channel serpentine cooling plates. A new approach with LHS and GRA is used to obtain the optimum ranges of design parameters to minimize the pressure drop, maximum temperature and to maximize the convective heat transfer coefficient. In this study, the values of the parameters for the numerical modeling are obtained by the experiments. The width and height of the serpentine channel and mass flow rate are chosen as input parameters and the pressure drop, convective heat transfer coefficient and maximum temperature are selected as output parameters. Comparing with the base design, the optimized design provided up to 40.3% decrease in the pressure drop with a penalty of 11.3% decrease in the convective heat transfer coefficient with a slight decrease in the maximum temperature. The proposed approach can be used to design better cooling plates to keep the batteries in safe temperature ranges and to reduce the power consumption by optimizing the pressure drop and maximum temperature values.Publication A new approach to automatically find and fix erroneous labels in dependency parsing treebanks(Zarka Private Univ, 2021-05-01) Bilgin, Metin; BİLGİN, METİN; Bursa Uludağ Üniversitesi/Mühendislik Fakültesi/Bilgisayar Mühendisliği Bölümü; AAH-2049-2021Dependency Parsing (DP) is the existence of sub-term/upper-term relations between the words that make up that sentence for each sentence in the text. DP serves to produce meaningful information for high-level applications. Correct labeling of the text corpus used in DP studies is very important. There will be mistakes in the results of the studies that will be performed with the wrongly-labeled text corpus. If text corpus is labeled manually or automatically by human beings, then faulty cases will occur. As a result of the cases that may arise from human factors or annotations used for labeling, faulty labels will be on freebanks. In order to prevent these errors, detection, and correction of possible faulty labeling is very important in terms of increasing the accuracy of the studies to be carried out. Manual correction of possible faulty labels requires great effort and time. The purpose of this study is to create a model that automatically finds possible faulty labels and offers new label suggestions for faulty labels. With the help of the proposed model, it is aimed to detect and correct possible faulty labels that are included in a text corpus, and to increase consistency among the text corpus of the same language. With the help of the developed model, suggesting new labels for faulty labels by a language expert will be a great convenient for the specialist. Another advantage of the model is that the developed model provides a language-independent structure. It has succeeded in obtaining successful results in finding and correcting potentially faulty labels in experimental studies for Turkish. An increase in accuracy has been detected in studies carried out for languages other than Turkish. In investigating the accuracy of the results obtained by the system, the results were analyzed with the help of 10 different language experts.Publication A new approach to measure parcel shapes for land consolidation(Kahramanmaraş Sütçü İmam Üniversitesi Rektörluğü, 2021-01-01) Arslan, Fırat; Değirmenci, Hasan; Akkaya Aslan, Şerife Tülin; Jurgenson, Evelin; AKKAYA ASLAN, ŞERİFE TÜLİN; 0000-0001-5129-8642; 0000-0003-2103-4333; N-8095-2019; ACD-0280-2022; N-9721-2013Land consolidation (LC) is of significant importance and is an application that, decreases land fragmentation level and deformed parcels, which reduce agricultural production. increasing fuel consumption and labor cost in the agriculture sector. The present research focuses on parcel shapes and investigates a new index measuring complexity of parcels. The most commonly used indices (fractal dimension, shape index, form factor. areal form factor, area perimeter ratios. and the number of points) are compared wit h the new shape index. The new shape index is calculated with the parcel's area and minimum bounding geometry of the parcel using geographic informal ion systems. The new approach was applied to the cadastral data consisting of different types of parcel shapes before LC in a village in Mersin, Turkey. The new shape index showed a good performance in terms of measuring shape complexity and is easily applicable. The presented method may be used to assess LC projects or to determine priority areas for I.C.Publication A new characterization of curves in minkowski 4-SPACE E 1 4(Univ Nis, 2020-01-01) Kisi, Ilim; Öztürk, Günay; Arslan, Kadri; ARSLAN, KADRİ; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Matematik Bölümü; AAG-8775-2021In this study, we attend to the curves whose position vectors are written as a linear combination of their Serret-Frenet vectors in Minkowski 4-space E-1(4). We characterize such curves with regard to their curvatures. Further, we get certain consequences of T-constant and N-constant types of curves in E-1(4).Publication A note on terai's conjecture concerning primitive pythagorean triples(Hacettepe Üniversitesi, 2021-01-01) Le, Maohua; Soydan, Gökhan; SOYDAN, GÖKHAN; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Matematik Bölümü; 0000-0002-6321-4132; M-9459-2017Let f,g be positive integers such that f > g, gcd(f,g) =1 and f not equivalent to g (mod 2). In 1993, N. Terai conjectured that the equation x(2) + (f(2) - g(2))(y) = (f(2) + g(2))(z) has only one positive integer solution (x, y, z) = (2 fg, 2, 2). This is a problem that has not been solved yet. In this paper, using elementary number theory methods with some known results on higher Diophantine equations, we prove that if f = 2(r)s and g = 1, where r, s are positive integers satisfying 2 inverted iota s, r >= 2 and s < 2(r-)(1), then Terai's conjecture is true.Publication A novel 2 bp deletion variant in ovine DRB1 gene is associated with increased visna/maedi susceptibility in Turkish sheep(Nature Portfolio, 2021-07-14) Yaman, Yalçın; Bay, Veysel; Aymaz, Ramazan; Keleş, Murat; Öner, Yasemin; Teferedegn, Eden Yıtna; Ün, Cemal; Öner, Yasemin; ÖNER, YASEMİN; Bursa Uludağ Üniversitesi/Ziraat Fakültesi.; JKO-1528-2023Visna/maedi (VM) is a multisystemic lentivirus infection of sheep that affecting sheep industry across the globe. TMEM154 gene has been identified to be a major VM-associated host gene, nevertheless, a recent study showed that the frequency of the VM-resistant TMEM154 haplotypes was very low or absent in indigenous sheep. Thus, the present study was designed to determine other possible co-receptors associated with VM. For this purpose, DRB1 gene, which is renowned for its role in host immune response against various diseases was targeted. A total number of 151 case-control matched pairs were constructed from 2266 serologically tested sheep. A broad range of DRB1 haplotype diversity was detected by sequence-based genotyping. Moreover, a novel 2 bp deletion (del) in the DRB1 intron 1 was identified. For the final statistic, the sheep carrying VM-resistant TMEM154 diplotypes were removed and a McNemar's test with a matched pairs experimental design was conducted. Consequently, it was identified for the first time that the 2 bp del variant is a genetic risk factor for VM (p value 0.002; chi-square 8.31; odds ratio 2.9; statistical power 0.90) in the dominant model. Thus, negative selection for 2 bp del variant could decrease VM infection risk in Turkish sheep.Publication A qualitative research on the social and economic dimensions of tibb al nabawi practices(Din Bilimleri Akad Araştırma Merkezi, 2021-01-01) Bilgin, Vejdi; Turan, Sümeyra Ünalan; BİLGİN, VEJDİ; ÜNALAN TURAN, SÜMEYRA; Bursa Uludağ Üniversitesi/İlahiyat Fakültesi/Din Sosyolojisi Anabilim Dalı; Bursa Uludağ Üniversitesi/İlahiyat Fakültesi/Din Sosyolojisi Anabilim Dalı; JDK-9518-2023; CDV-1489-2022In the present study, the religious-health is discussed on the relationship between religion and health focusing in Tibb al-Nabawi, which is at the center of religion-health intersection. The purpose of the study was to reveal the effects of Sunnah in the health-related experiences of individuals, the processes of turning to Tibb Al-Nabawi, positive and negative outcomes of the sector with the eyes of the participants, and the legitimacy function of religion in healthcare. In this study, which was conducted with the phenomenology design, the data were obtained with in-depth interviews conducted with nine females and six male participants. The study group was created from people who applied Tibb al-Nabawi treatments. As a result of the study, it was determined that religion is effective in preferring these practices, especially for those who have religious identity. These people also choose religious- traditional practitioners who did these procedures by reading verses and prayers instead of clinics and hospitals in the scope of Traditional and Complementary Medicine (GETAT) for Hijama (The Wet Cupping Therapy) application. Especially the participants who graduated from Theology Faculty believed that Tibb al-Nabawi treatments became an economic sector, and that religion was used as a means of legitimacy and abuse of religious emotions in this sector. Although the tendency to individualize in healthcare comes to the forefront in the behavior of applying to Tibb al-Nabawi, the relations between religion and health in participants, who are affiliated with Aidin Salih school, seems to have changed from an individual sphere to a religious-health-based movement.Publication A quest for sustainability of cultural heritage sites: The hanlar district of Bursa, Turkey(Konya Teknik Üniversitesi, 2019-04-08) Polat, Sibel; Çahantimur, Arzu; Atanur, Gül; Yıldız, H. Özge Tümer; POLAT, SİBEL; ÇAHANTİMUR, ARZU; TÜMER YILDIZ, HİKMET ÖZGE; Bursa Uludağ Üniversitesi/Mimarlık Fakültesi/Mimarlık Bölümü.; 0000-0003-4380-0457; 0000-0002-5907-1773; 0000-0002-7755-9238; AAH-2742-2021; KJK-5232-2024 ; H-4326-2013Today, many studies have been carried out to support community engagement in planning and urban design processes in Turkey. This study which tries to bring together community engagement and urban design within the framework of sustainability of cultural heritage sites is a part of a scientific research project which aims to create a participative model to develop an urban design guideline for the Hanlar District, a historical commercial district including many inns in the city centre of Bursa, in Turkey. While a series of community engagement techniques were experimented during the project process, the aim of this article is to examine the potential benefits of using educational charrettes as a kind of design charrette to establish a participatory and competitive platform including public, private, voluntary actors and local people in urban design process of heritage sites. It overviews the charrette use in developing adaptive re-use and urban design schemes for the inns and their surrounding public spaces which are not actively used in the Hanlar District which has been a UNESCO world heritage site since 2014, and then highlights the proposals that were developed in terms of the objectives of the Bursa and Cumalikizik Management Plan. Finally, this study presents the usability, suitability and practicability of educational charrettes as a community engagement way in the urban design process of the heritage sites while enabling different actors to create new visions to sustain heritage sites. However, it also emphasizes the need for a participatory and holistic urban design process for the Hanlar District of Bursa including the adaptive re-use strategies for the inns to sustain the district.Publication A rare case of juvenile amyotrophic lateral sclerosis(Türk Pediatri Dergisi, 2021-05-01) Bodur, Muhittin; Toker, Rabia Tütüncü; Başak, Ayşe Nazlı; Okan, Mehmet Sait; BODUR, MUHİTTİN; TÜTÜNCÜ TOKER, RABİA; OKAN, MEHMET SAİT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk Nörolojisi Anabilim Dalı; 0000-0002-2588-8195; 0000-0002-3129-334X; 0000-0002-9303-5768; JAN-9435-2023; AAH-2684-2021; IZP-6290-2023; DKC-6496-2022Background. Amyotrophic lateral sclerosis (ALS) is a chronic motor neuron disease characterised by progressive weakness in striated muscles resulting from the destruction of neuronal cells. The term juvenile ALS (JALS) is used for patients whose symptoms start before 25 years of age. JALS may be sporadic or familial.Case. Here, we present a sporadic case of JALS because of its rarity in children. The heterozygous p.Pro525Leu (c.1574C>T) variation was identified in the fused in sarcoma (FUS) gene.Conclusion. The p.Pro525Leu mutation in the FUS gene has been detected in patients with ALS, characterised by early onset and a severely progressive course.Publication A real-life Turkish experience of venetoclax treatment in high-risk myelodysplastic syndrome and acute myeloid leukemia(Cig Media Group, 2021-08-10) Gemici, Aliihsan; Dogu, Mehmet Hilmi; Tekinalp, Atakan; Alacacioglu, Inci; Guney, Tekin; Ince, Idris; Geduk, Ayfer; Cağlıyan, Gulsum Akgun; Maral, Senem; Serin, Istemi; Gunduz, Eren; Karakus, Volkan; Bekoz, Huseyin Saffet; Eren, Rafet; Gunes, Ahmet Kursad; Sargin, Fatma Deniz; Sevindik, Omur Gokmen; Ozkalemkas, Fahir; ÖZKALEMKAŞ, FAHİR; Pinar, Ibrahim Ethem; PINAR, İBRAHİM ETHEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Hematoloji Anabilim Dalı.; JWP-2738-2024; AAA-5330-2022Venetoclax is a selective B-cell lymphoma 2 (BCL2) inhibitor, which is approved to treat elderly patients with newly diagnosed acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). A total of 60 patients with a median age of 67 years from different centers were included in the final analysis. Our real-life data support the use of venetoclax in patients with both newly diagnosed and relapsed high-risk MDS and AML.Introduction: Venetoclax is a selective B-cell lymphoma 2 (BCL2) inhibitor, which is approved to treat elderly patients with newly diagnosed acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) in combination with either low-dose cytarabine (ARA-C) or hypomethylating agents. We aimed to collect and share data among the efficacy and safety of venetoclax both as a monotherapy or in combination with other drugs used to treat high-risk MDS or AML. Materials and Methods: A total of 60 patients with a median age of 67 (30-83) years from 14 different centers were included in the final analysis. Thirty (50%) of the patients were women; 6 (10%) of the 60 patients were diagnosed with high-risk MDS and the remaining were diagnosed with AML. Results: The best objective response rate (complete remission [CR], complete remission with incomplete hematological recovery (CRi), morphological leukemia-free state [MLFS], partial response [PR]) was 35% in the entire cohort. Best responses achieved during venetoclax per patient number were as follows: 7 CR, 1 CRi, 8 MLFS, 5 PR, and stable disease. Median overall survival achieved with venetoclax was 5 months in patients who relapsed and not achieved in patients who were initially treated with venetoclax. Nearly all patients (86.7%) had experienced a grade 2 or more hematologic toxicity. Some 36.7% of these patients had received granulocyte colony stimulating factor (GCSF) support. Infection, mainly pneumonia (26.7%), was the leading nonhematologic toxicity, and fatigue, diarrhea, and skin reactions were the others reported. Conclusion: Our real-life data support the use of venetoclax in patients with both newly diagnosed and relapsed high-risk MDS and AML. (C) 2021 Elsevier Inc. All rights reserved.Publication A scenario-based decision support system for allocating temporary-disaster-response facilities(Gazi Üniversitesi, Mühendislik Mimarlık Fakültesi, 2021-01-01) Çavdur, Fatih; Sebatli-Sağlam, Aslı; Köse-Küçük, Merve; ÇAVDUR, FATİH; Sebatli-Sağlam, Aslı; KÖSE KÜÇÜK, MERVE; Bursa Uludağ Üniversitesi/Endüstri Mühendisliği Bölümü; 0000-0002-9445-6740; 0000-0001-6877-2937; AAC-2099-2020; JYP-7925-2024; AAE-4504-2019Disaster operations management is carried out in a chaotic environment under uncertainty and time pressure. Therefore, it is necessary to use information and communication technologies in the decision making processes. In this study, a standalone decision support system is developed for temporary-disaster-response facilities allocation for relief supplies distribution as one of the important problems in disaster operations management. The decision support system consists of three main components as its database, decision engine and user interface. It is noted that the decision support system allows decision makers to allocate temporary-disaster-response facilities under many different disaster situations by utilizing a scenario-based approach. Thus, disaster operations managers are given the opportunity to create different scenarios and analyze the results that will help them make critical decisions before and during the disaster. In the scenario definition process, in addition to taking into account different values of affected population rate and planning period, some model configurations consisting of the combinations of various problem parameters are also defined. Although it is illustrated with a specific example case in this paper, the flexibility of the system allows its users to consider other cases with different scenarios. Due to the user-friendly interface of the decision support system, reports of the results obtained for various disaster scenarios are presented to the user in an understandable way. The proposed system might be a useful tool to help decision makers in allocating temporary-disaster-response facilities for relief supplies distribution.Publication A subclass of bi-univalent functions based on the faber polynomial expansions and the fibonacci numbers(Mdpi, 2019-02-01) Altınkaya, Şahsene; Yalçın, Sibel; Çakmak, Serkan; ALTINKAYA, ŞAHSENE; YALÇIN TOKGÖZ, SİBEL; Çakmak, Serkan; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Matematik Bölümü; 0000-0002-7950-8450; 0000-0002-0243-8263; 0000-0003-0368-7672; AAE-9745-2020; ABC-6175-2020; GZG-2072-2022; AAA-8330-2021In this investigation, by using the Komatu integral operator, we introduce the new class ( pound eta,rho)(Sigma,t)((rho) over tilde of bi-univalent functions based on the rule of subordination. Moreover, we use the Faber polynomial expansions and Fibonacci numbers to derive bounds for the general coefficient vertical bar a(n)vertical bar of the bi-univalent function class.