PubMed

Permanent URI for this collectionhttps://hdl.handle.net/11452/24864

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Changing caveolin-1 and oxytocin receptor distribution in the ageing human prostate
(Wiley, 2007-10) Herbert, Zsofia; Boetticher, Gregor; Aschoff, Anna Teresa; Zermann, Dirk Henrik; Arnold, R.; Mall, G. M.; Jirikowski, Gustav F.; Şendemir, Erdoğan; Tıp Fakültesi; Anatomi Bölümü; 0000-0001-9699-4342; AAA-9892-2021; 2-s2.0-34548535909
Several observations suggest that caveolin-1 has an important role in control of cell proliferation and cancerogenesis. For instance, oxytocin provokes a proliferative response in the prostate tissue when the oxytocin receptor is localized mainly in caveolin-1-enriched domains and an anti-proliferative effect when the same receptor is not localized in caveolae. Moreover, oxytocin concentrations are elevated in prostate tissue of patients with benign prostatic hyperplasia (BPH). In this study the expression pattern of the molecules caveolin-1, oxytocin receptor, androgen receptor and p21 (cell cycle arrest indicator) was investigated in the prostate tissue of BPH patients and of young controls.We found that both caveolin-1 and oxytocin receptor expression is drastically increased with age in both smooth muscle and epithelium of the prostate. We also found a significantly increased co-localization of the oxytocin receptor with caveolin-1 in both the muscle and the epithelium, especially in BPH patients. Androgen receptor and p21 staining was found throughout the prostate but did not change significantly with age or in BPH patients. We conclude that oxytocin may have a proliferative effect on the prostate tissue through the caveolae-associated receptors and thus contribute to BPH. This process seems to be androgen receptor independent.
The peri-microvascular edema in hippocampal CA1 area in a rat model of sepsis
(Wiley, 2007-07) Kafa, İlker Mustafa; Arı, İlknur; Kurt, Mustafa Ayberk; Tıp Fakültesi; Anatomi Bölümü; 0000-0003-3368-8123; AAG-7125-2021; AAR-4341-2020; 8450193200; 8450193100; 35603735000
Encephalopathy is a common complication of sepsis. However, little is known about the morphological changes that occur in the brain during sepsis. In this study, fecal peritonitis was induced in Wistar rats, which had been monitored for 4 h before their brains were removed and samples from the CA1 area taken. In addition to higher blood pressure with a decreasing pattern and a significant drop in rectal temperature, an increased heart rate and marked respiratory failure were observed. The tissue was investigated and compared with corresponding hippocampal samples taken from sham-operated and not operated control groups. Significantly more peri-microvascular edema was found in the hippocampal CA1 area in the septic group. The percentages of the peri-microvascular edema were 158.57 +/- 3.6%, 122.84 +/- 1.5% and 120.24 +/- 1.9% in the fecal peritonitis group, sham-operated and not operated control groups, respectively. The results may suggest that the edema observed around the microvessels may participate in the pathogenesis of the septic encephalopathy probably by causing in the microvascular permeability characteristics.
Prevalence of dental caries and tooth wear in a Byzantine population (13th C. AD) from northwest Turkey
(Pergamon Elsevier Science, 2007-12) Çağlar, Eser; Sandallı, Nükhet; Kuşçu, Özgür Önder; Arı, İlknur; Tıp Fakültesi; Anatomi Bölümü; 8450193100
Dental caries and wear are important conditions to record in archaeological collections. Reconstruction of the life of ancient peoples can be accomplished by studying their dental remains. The aim of the present paper was to determine the frequency, distribution, and characteristics of dental caries, dental wear and related diet in the mediaeval Byzantine population of Iznik in northwest Turkey. The analysed sample consisted of the dental remains of 56 individuals with the total of 280 teeth. The majority(261 or 93.2%) of the teeth belonged to the permanent dentition. The frequency of antemortem tooth loss in the sample was 6.5% and the frequency of caries was 6.8%. The most frequent recorded caries were mesial (3.3%), followed by buccal (3%). The frequency of dental wear was rather high (84.2%) exhibiting presence of dentin clusters mostly. This finding is consistent with the hypothesis of caries attrition competition based on the assumption that a beneficial effect of tooth wear is to avoid development of caries. High wear in the archaeological population can be linked to the fact that the cumulative effects of attrition as a result of the Byzantine diet.
Statistical shape analysis of differences in the shape of the corpus callosum between genders
(Wiley, 2007-07) Sevinç, Özdemir; Barut, Çağatay; Özdemir, Senem Turan; Ercan, İlker; Güney, İbrahim; Ocakoğlu, Gökhan; Aslan, Elif; Tıp Fakültesi; Matematik Bölümü; 0000-0001-8290-6532; 0000-0002-2382-290X; 0000-0003-0176-4961; AAA-8734-2021; AAH-5180-2021; ABF-8301-2020; 18038353400; 6603789069; 36912189400; 15832295800; 18036895500
Sexual dimorphic characteristics, which play an important role in human evolution studies and biological research, can be studied morphologically and metrically. Geometric morphometrics allows a better assessment of morphological characteristics. Statistical shape analysis has a long history in neuroanatomical and other research. The aim of this study was to identify shape differences of the corpus callosum between genders. Landmark coordinate data were collected from two-dimensional magnetic resonance imaging scans of 93 homogeneously aged patients, 45 men and 48 women. These data were analyzed using Euclidean distance matrix analysis and thin plate spline analysis. The general shape variability of the corpus callosum of men was greater than that of women (men, 0.134; women, 0.097). We found no significant difference between sexes in the general shape of the corpus callosum, but we did find significant differences in the distances between some landmarks. Deformation of the corpus callosum between men to women was mainly detected in the posterior of the corpus callosum. These results serve as a reference for future studies on shape alterations of the corpus callosum associated with certain conditions.

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