PubMed

Permanent URI for this collectionhttps://hdl.handle.net/11452/24864

Browse

Now showing 1 - 20 of 759

Giant lymphoid hamartoma of mediastinum (Castleman's Disease)
(Georg Thieme Verlag, 1990) Özkan, Hayati; Tolunay, Şahsene; Gözü, Oktay; Özer, Z. G.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Kalp Damar Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.
The giant lymphoid hamartoma is known as a rare, benign, large, solitary, encapsulated mass of lymphoid tissue. It frequently involves mediastinum or pulmonary hilum. It may also occur in other various locations. Few of the patients may have general Symptoms. The disease has been divided into two variants according to microscopic structure. These are hyaline vasculartype and plasma-cell type. The hyaline vasculartype is benign but the plasma-cell type meets malignancy criteria, so that the plasma-cell type has been subject to discussion whether it is suited to chemothorapy or not. Our case was a 55-year-old male with persistent cough. There was a mass having a size of 6 centimeters on left pulmonary hilum on ehest radiograph. Left thoracotomy was performed and a hilar lymphoid mass removed. The biopsy Unding was “hyaline vascular type giant lymphoid hamartoma”. No other therapy was done. Patient is well six months after the operation.
Public attitudes toward organ donation- A survey in a Turkish community
(Springer Verlag, 1991-07-01) Bilgel, Halil; Bilgel, Nazan; Okan, Necla; Kılıçturgay, Sadık; Özen, Yilmaz; Korun, Nusret; Uludağ Üniversitesi/Tıp Fakültesi/Halk Sağlığı Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; 0000-0002-4539-5849
A survey of public attitudes toward organ donation and transplantation was conducted in a Turkish community. The 1030 subjects were chosen using a random, stratified method. Some 50.5 % of those interviewed were willing to donate their organs while 33.7 % refused and 15.8 % were uncertain. A total of 53.6% said they would consent to donate a deceased relative's organs. Reasons for refusal to donate organs were as follows: fear that their body would be cut into pieces (43.8 %), religious beliefs (26.2%), no reason (23.1%) and the belief that they would need their body and organs for their second life (6.9 % ). Attitudes toward organ donation were clearly related to level of education, age, sex, and socioeconomic status.
Long-term neurologic and psychomotor sequelae after neonatal tetanus
(Sage Publications, 1997-06) Okan, Mehmet; Hacımustafaoğlu, Mustafa; Ildırım, İbrahim; Dönmez, Osman; Eralp, Özgen; Özer, E. Tülay; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Nörolojisi ve Çocuk Enfeksiyon Hastalıkları Anabilim Dalı.; AAA-8778-2021
Detection of IgG antibody to Bovine Leukaemia Virus in urine and serum by two enzyme immunoassays
(Wiley, 1999) Çarlı, Kamil Tayfun; Şen, Ayşin; Batmaz, Hasan; Kennerman, Engin; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0003-1991-8957; AAH-1712-2021; E-3867-2010; 6601971539; 7401592869; 6602783183; 16031244000
Four hundred blood sera from a cattle production unit were tested for BLV-(Bovine Leukaemia Virus) antibody with IP (Institut Porquier) and SE (Svanova Biotech) ELISA kits. Seventy-seven cattle with BLV-antibody (19.25%) and 77 without the antibody were used. No significant difference was found between O.D. of sera of PL + (Persistent Lymphocytosis Positive) and PL-(Negative) cattle. The mean O.D. of urine samples of 77 seropositive cattle was significantly higher than that of 77 seronegative cattle (P < 0.01). There were also differences between urine O.D.s of seropositive (PL +) and seropositive (PL-) groups of cattle with IP (P < 0.05) and SB (P < 0.01) kits. All the results revealed the presence of BLV-antibody in the urine of the cattle without any urinary dysfunction.
Fatal hydrothorax due to misplacement of a nasoenteric feeding tube
(Sage Publications, 2001) Acar, H. Volkan; Kahveci, Ferda; İşçimen, Remzi; Gurbet, Alp; Uysal, Hale Yarkan; Kutlay, Özden; Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı.; AAG-9356-2021; 6602742300; 7007146835; 16645821200; 35618853300; 8290444400; 6602199747
Blind nasoenteric intubation was attempted in a patient with chronic parkinsonism. The tube was inadvertently misplaced and penetrated the left pleural cavity. The next day, the patient developed cardiopulmonary arrest during dietary supplement infusion. This complication ultimately led to the patient's death. We have reviewed the known complications of nasoenteric tube placement and conclude that difficult insertion in patients at risk from tube misplacement should be followed by chest radiography to confirm the correct placement of the tube before nutritional support is started.
Effect of retinopathy of prematurity on resolution acuity development in 1-to 3-year-old children
(Slack, 2001) Shirabe, Hirotsugu; Nakamura, Makoto; Taoka, Kazuki; Nomura, K.; Yamamoto, M.; Doğru, Murat; Uludağ Üniversitesi/Tıp Fakültesi/Oftalmoloji Bölümü.; 7006540932
Purpose: To assess the pattern of visual development in children aged 1-3 years with stage 1-3 retinopathy of prematurity (ROP). Methods: One hundred forty-four infants weighing <1500 g were divided into three groups according to ROP stage. Randomly chosen preterm infants were the controls. Ophthalmic examinations started 4-7 weeks after birth and were performed until the retina was fully vascularized or until any ROP that had developed resolved. Preferential looking acuity measurements were carried out at 12, 18, 24, and 36 months of age. Results: Infants with stage 1-2 or no ROP showed evidence of improving acuity development after 12 months. Infants with stage 3 ROP had significantly lower acuity scores compared to infants with stage 1-2 or no ROP at the 18- and 24-month follow-up examinations (P<.001). At 36 months, the visual acuity of infants with stage 3 ROP showed evidence of improving development but still lagged behind infants with stage 1-2 or no ROP. Conclusion: Although mild ROP does not seem to have a considerable effect on the development of resolution acuity until age 3, severe forms of ROP may be associated with impaired visual development, which strongly suggests the necessity of periodic monitoring of early visual acuity in infants with ROP.
Polystoma macrocnemis n. sp. (Monogenea: Polystomatidae) from the Iranian longlegged wood frog Rana macrocnemis (Ranidae) in Turkey
(Springer, 2001-01) Biserkov, Valko Y.; Buchvarov, G.; Yıldırımhan, Hikmet Sami; Uğurtaş, İ. H.; Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü.; AAC-1581-2020; 6603101555; 6603658894
Polystoma macrocnemis n. sp. (Polystomatidae) is described from the urinary bladder of Rana macrocnemis (Ranidae) in Turkey. Its general morphology is similar to that of other members of the genus, but it is distinguished from closely related species by numerical parameters of the hamuli and also by its host species and geographical range.
Cardiac rupture following blunt trauma
(Wiley, 2001-01-01) Durak, Dilek; Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.; 0000-0003-3469-340X; AAH-6587-2021; 56700124800
A case of cardiac rupture following blunt trauma with no additional injuries is described. This can be a difficult diagnosis because of the presence of additional injuries and the lack of clinical symptoms. Here, there was a rupture of the pericardium, all chambers of the heart and the thoracic aorta.
Prevalence of transfusion-transmitted virus (TTV) in patients with primary glomerulopathies
(Dustri Verlag, 2001-04) Usta, Mehmet; Dilek, Kevser; Dalkılıç, Ediz; Güllülü, Mustafa; Mıstık, R.; Yavuz, Mahmut; Ersoy, Alparslan; Yurtkuran, Mustafa Abbas; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021; 7005030712; 56005080200; 6506739457; 6602684544; 6504789868; 7006244754; 35612977100; 7003389525
Re-emergence of visceral leischmaniasis: Important diagnostic features
(Oxford University Press, 2001-06) Güneş, Adalet Meral; Sevinir, Betül Berrin; Ülgen, Günay; Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı/Hematoloji Bölümü.; 6602571317; 6603199915; 6603885274
Inhibitory effects of ascorbic acid and folinic acid on chromosome aberrations induced by pyrimethamine in vitro
(Wiley-Liss, 2002) Egel, Çiğdem; Bilaloğlu, Rahmi; Aydemir, Nilüfer; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; 0000-0002-3595-6286; AAH-5296-2021; 6507862539; 6505804122; 26533892300
In this study, the anticlastogenic effects of ascorbic acid and the protective effect of folinic acid against the formation of chromosomal aberrations in humans by pyrimethamine were investigated. Pyrimethamine is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. In this study, 18 different healthy people, who do not drink alcohol and are non-smokers, were chosen as an experimental group; 0.025 mg/ml pyrimethamine was given to the lymphocyte culture, which had been prepared with the peripheral blood taken from this group. After that each of the following doses were given to the same culture: 20, 40, and 80 mM of ascorbic acid and 25, 50, and 100 mM of folinic acid. The results of the cytogenetic evaluation showed that the aberrations due to pyrimethamine in the chromosomes were reduced by ascorbic acid and folinic acid significantly, depending on the given dose.
Experimental subarachnoid haemorrhage models in rats
(Springer-Verlag Wien, 2002) Kanpolat, Y.; Alkan, Tülin; Korfalı, Ender; Kahveci, Nevzat; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; 0000-0003-0841-8201; AAG-7070-2021; 6601953747; 7004641343; 6602597846
There is no comprehensive and reliable model available in small animals that are suitable for the study of subarachnoid haemorrhage (SAH). In the study we reviewed the advantages and disadvantages of available SAH models in rats and presented our model. Experimental SAH was induced in a group of 350-450 g SpragueDawley rats. A 2 mm-diameter burr hole was drilled and, working under a microscope, haemorrhage was produced by transclival puncture of the basilar artery with a 20 mum thick piece of glass. The rats were assigned to either the experimental group (n: 7) or the control group (n: 7). Local cerebral blood flow (LCBF), intracranial pressure (ICP), and cerebral perfusion pressure (CPP) were measured for 60 min after SAH, after which the rats were decapitated. Microscopic examinations were done on three different segments of the basilar artery. There was a significant and sharp drop in LCBF just after SAH was induced (56.17 +/- 12.80 mILD/min/100 g and 13.57 +/- 5.85 mILD/min/100 g for baseline and post-SAH, respectively; p < 0.001), the flow slowly increased by the end of the experiment but never recovered to pre-SAH values (43,63 +/- 7.6 mILD/min/ 100 g, p < 0.05). ICP (baseline 7.33 +/- 0.8 mmHg) increased acutely to 70.6 +/- 9.2 mmHg, and also returned to normal levels by 60 min after SAH. CPP (baseline 75.1 +/- 4.9 mmHg) dropped accordingly (to 21.0 +/- 6.3 mmHg) and then increased, reaching 70.1 +/- 4.9 mmHg at 60 min after SAH. Examinations of the arteries revealed decreased inner luminal diameter and distortion of the elastica layer. We present an inexpensive and reliable model of SAH in the rat that allows single and multiple haemorrhages and to study the early and late course of pathological changes.
Takayasu arteritis
(BMJ Publishing Group, 2002-01-01) Kılıç, Sara Şebnem; Bostan, Özlem M.; Çil, Ergün; Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Bölümü.; AAH-3865-2021; AAH-1658-2021; AAH-1658-2021; 6507257740; 8676936500; 35587943300
Evaluation of the need for routine preoperative latex allergy tests in children
(Wiley, 2002-03-11) Sapan, Nihat; Canitez, Yakup; Sağlam, Halil; Nacarküçük, Ergün; Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0003-0710-5422; C-7392-2019; 6602156485; 6602924559; 8988954700; 35612700100
Background: Recently, there was a great increase in allergic reactions to latex and this brought relatively more concern to the latex allergy. In this prospective study we aimed to identify the frequency of latex allergy in preoperative patients, and tried to clarify whether it is necessary to perform latex allergy tests routinely in the preoperative period or not. Methods: A total of 188 children, aged 1-14, who were admitted for various operations, were randomly included in this study and of them, 181 completed the study. Latex specific history was taken from all patients. Latex skin prick tests, challenge tests with latex gloves, total IgE and latex specific IgE measurements were performed. Results: Of 181 children, two (1.1%) had positive latex skin prick tests. Latex challenge tests were negative in all children. Latex specific IgE was positive in 12 children (6.6%) as class II or higher, but no patient had allergic reactions in operations. History of repeated operations was a risk factor for latex sensitization. The risk was higher in the presence of both history of repeated operations and history of allergic disease. However, the risk was not higher in patients with the history of only allergic disease, compared to ones who had a history of neither repeated operations nor allergic disease. Conclusion: We conclude that routine preoperative latex allergy tests seem to be not necessary because of no allergic reactions during operation in spite of the sensitization of 6.6% detected by latex specific IgE. However, this should be investigated in larger studies.
Angiotensin-II receptor antagonist losartan reduces micro albuminuria in hypertensive renal transplant recipients
(Wiley, 2002-06) Alparslan, Ersoy; Dilek, Kamil; Usta, Mehmet; Yavuz, Mahmut; Güllülü, Mustafa; Yurtkuran, Mustafa Abbas; Oktay, Burçin; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0710-0923; AAH-5054-2021; 35612977100; 56005080200; 7005030712; 7006244754; 6602684544; 6602172127; 7003389525
In recent years, it has been demonstrated that losartan lowers macroproteinuria in diabetic or non-diabetic renal transplant recipients (RTx) similar to angiotensin converting enzyme (ACE) inhibitors. Microalbuminuria (MAU) may reflect subclinical hyperfiltration damage of the glomerulus. It could be a marker of kidney dysfunction in renal transplantation. The aim of the study was to assess the efficacy of losartan in hypertensive RTx with MAU. This study was conducted in 17 (M/F: 4/13) stable RTx. No change was made in the medical treatment of the patients. All cases received 50 mg/day losartan therapy for 12 wk. Renal functions and MAU were determined 12 and 6 wk and just before the treatment as well as sixth and twelfth week of the treatment in all patients. Losartan satisfactorily lowered systemic blood pressure. A significant reduction in MAU was observed from 103 +/- 53 mug/min at the beginning to 59 +/- 25 mug/min in the sixth week and 47 +/- 24 mug/min in the twelfth week (p = 0.0007 and 0.0005, respectively). From the sixth week of the treatment, the therapy significantly decreased hemoglobin, hematocrit and erythrocyte levels but did not change mean leukocyte and platelet counts, urea, creatinine levels and creatinine clearances. No serious side-effect was observed,during the study. In conclusion, we found that losartan decreased MAU in hypertensive RTx. For that reason, it might be considered as the first choise antihypertensive agent for the renoprotection in selected patients.
Complex regional pain syndrome after thromboendarterectomy - Which type is it?
(Lippincott Williams & Wilkins, 2002-09) Planchon, C. A.; Baillet, G.; Thomassin, Michel; Foult, Jean Marc; Tamgaç, Feyzi; Uludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı.; 35569192500
The authors describe a complex regional pain syndrome (CRPS) and discuss its type according to the presence or absence of nerve injury. A patient underwent thromboendarterectomy of the right popliteal artery. Subsequently, right lower limb reflex sympathetic dystrophy developed, which was confirmed by scintigraphy and responded well to calcitonin treatment. Typing according to the new classification of CRPS type I or II with possible nerve injury is discussed, and a short review of the literature is included.
A case of syringocystadenoma papilliferum: An unusal localization on postoperative scar
(Wiley, 2002-10-02) Sarıcaoğlu, Hayriye; Başkan, Emel Bülbül; Özuysal, Sema; Tunalı, Şükran; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabiilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-0144-3263; AAH-1388-2021; 6603722836; 6602518817; 56616314600; 7004191748
Corneal sensitivity and ocular surface changes following preserved amniotic membrane transplantation for nonhealing corneal ulcers
(Springernature, 2003-03) Doğru, Murat; Yıldız, Meral; Baykara, Mehmet; Özçetin, Hikmet; Ertürk, Haluk; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 7006540932; 35791194600; 23093006700; 6603402155; 7003716972
In summary, we found that AMT can be helpful for the treatment of epithelial defects and stromal ulcers. We came to learn that cases with total limbal deficiency or extensive ocular surface inflammation may not be cured with AMT alone. AMT provides improvement of corneal sensitivity, tear film stability and impression cytology parameters. However, the entire mechanism of the healing effect of amniotic membrane is still unknown. A recent experimental study revealed that amniotic membrane transplantation vs tarsorraphy in murine HSV-1 stromal keratitis resulted in improvements in substance-P-related corneal nerve fibres in eyes treated with amniotic membrane, but not in eyes treated with tarsorraphy. We think that prospective, controlled, comparative studies of corneal ulcers treated by, for instance, tarsorraphy or other modalities should be performed to investigate whether the beneficial changes of amniotic membrane transplantation are greater or lesser than the changes that might have been observed by an alternative treatment. In this study, we tried to point to the effects of amniotic membrane transplantation on the ocular surface together with the problematic and unresolved issues. Thus, it is our sincere belief that further studies should be carried out along these lines.
Mutations in GCR1 affect SUC2 gene expression in Saccharomyces cerevisiae
(Springer Heidelberg, 2003-03) Turgut, T.; Lopez, Maria Cecilia; Uemura, Hiroshi; Baker, Henry V.; Türkel, Sezai; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; AAH-6281-2021; 7003319075
Transcription of SUC2, the gene that encodes the cytoplasmic and secreted forms of the enzyme invertase, is controlled by glucose repression and derepression mechanisms in Saccharomyces cerevisiae. Several regulatory factors such as the Mig1p-Tup1p-Ssn6p repressor complex and the Snf1p kinase complex have been identified previously as regulators of SUC2 expression. We show that, in addition to these factors, expression of SUC2 is affected by mutations in the gene GCR1 that encodes the glycolysis regulatory protein Gcr1p. Expression of Suc2-LacZ was not repressed by glucose in gcr1 mutant yeast cells exposed to glucose. Furthermore, secreted invertase activity was constitutively expressed under glucose-repressed and derepressed conditions in gcr1 mutants. DNA gel mobility shift assays and in-vitro DNase I protection experiments mapped a DNA binding site for Ger1p in the transcriptional control region of the SUC2 gene, next to a previously mapped Mig1p binding site. However, the mechanism by which gcr1 mutations relieve glucose repression remains obscure.
In vitro and in vivo study of Tc-99m-MIBI encapsulated in PEG-liposomes: A promising radiotracer for tumour imaging
(Springer, 2003-04) Belhaj-Tayeb, Hayet; Briane, Dominique; Vergote, Jackie; Kothan, Suchart; Leger, Gerard; Bendada, Saad-Eddine; Tofighi, Mojdeh; Tamgaç, Feyzi; Uludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı.; 0000-0002-2325-7728; 35569192500
Encapsulation of technetium-99m sestamibi (Tc-99m-MIBI) in polyethyleneglycol-liposomes (Tc-99m-MIBI-PEG-liposomes) could extend the duration of its circulation in blood and alter its biodistribution, enabling its concentration in tumours to be increased. An original method to encapsulate Tc-99m-MIBI in PEG-liposomes is described. The Tc-99m-MIBI-PEG-liposomes were compared with free Tc-99m-MIBI with respect to (a) tumour availability (b) ability to distinguish between chemotherapy-sensitive and -resistant cells and (c) uptake ratio in tumour imaging. PEG-liposomal systems composed of distearoylphosphatidylcholine/cholesterol/PEG(2000)-distearoyl phosphatidylethanolamine and lissamine-rhodamine B-labelled liposomes were used. The encapsulation of 99mTc-MIBI in liposomes was achieved using the K+ diffusion potential method. We compared the uptake of free versus encapsulated Tc-99m-MIBI by sensitive and resistant erythroleukaemia (K562) and breast tumour (MCF-7ras) cells. To assess the internalisation of these liposomes into cells, rhodamine B-labelled PEG-liposomes were used and visualised by fluorescence microscopy. Biodistribution and imaging characteristics of encapsulated and free radiotracer were determined in rats and tumour-bearing nude mice. The efficiency of Tc-99m-MIBI encapsulation in PEG-liposomes was 50+/-5%. Use of Tc-99m-MIBI-PEG-liposomes did not impair the ability of this tracer to distinguish between chemotherapy-sensitive and -resistant tumour cells; the percentage of radio-activity accumulated in the sensitive K562 cells was 1.24+/-0.04%, as compared with 0.41+/-0.04% in the resistant K562 cells. One hour post injection in rats, PEG-liposomes showed a ten times higher activity in blood than free Tc-99m-MIBI, whereas activity of free Tc-99m-MIBI in kidneys and bladder was markedly higher than that of encapsulated Tc-99m-MIBI, indicating faster clearance of the free radiotracer. In the (MCF7-ras)-bearing nude mice, PEG-liposome uptake in tumour was two times that of free Tc-99m-MIBI. Summarising, the Tc-99m-MIBI-PEG-liposomes demonstrated a longer blood circulation time, enabled distinction between chemotherapy-sensitive and -resistant cells and improved tumour to background contrast in in vivo imaging. Tc-99m-MIBI-PEG-liposomes therefore show promising potential for tumour imaging.

Browse

Browsing by Issue Date