PubMed

Permanent URI for this collectionhttps://hdl.handle.net/11452/24864

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Cardiac rupture following blunt trauma
(Wiley, 2001-01-01) Durak, Dilek; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0003-3469-340X; AAH-6587-2021; 56700124800
A case of cardiac rupture following blunt trauma with no additional injuries is described. This can be a difficult diagnosis because of the presence of additional injuries and the lack of clinical symptoms. Here, there was a rupture of the pericardium, all chambers of the heart and the thoracic aorta.
Fatal blunt trauma of the larynx in a child
(Wiley, 2005-09) Saka, Naile Esra; Durak, Vahide Aslıhan; Durak, Dilek; Fedakar, Recep; Eren, Bülent; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-8296-5484; 0000-0003-3469-340X; AAK-8096-2021; AAH-6587-2021; AAH-6287-2021; 56700124800; 8725968900; 8725969000
We report an autopsy case of an 11-year-old girl who suffered mechanical asphyxia from falling off the metal bars in the playground. This autopsy case is interesting because of the atypical trauma and lesions. To our knowledge there has been no similiar published case reports in the forensic literature. The young age of the victim, the setting and the pattern of the injuries are rare in a fall at playground by a child.
MMP-2, TIMP-2 and CD44v6 expression in non-small-cell lung carcinomas
(Academy of Medicine Singapore, 2008-01) Sar, Mehmet; Öz, Büge Turkili; Öner Dinçbas, Fazilet; Eren, Bülent; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-8296-5484; AAK-8096-2021; 8725969000
Introduction: Factors that emerge as crucial participants in tumour invasion and metastases are matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinase (TIMP) inhibitors and cellular adhesion molecules (CD44 and similar molecules). They play important roles in tumour invasion and metastasis in non-small-cell lung carcinomas (NSCLCs). Materials and Methods: The study was performed using the data of 33 patients. MMP-2 from the metalloproteinase family, TIMP-2 from the metalloproteinase inhibitor family and the adhesion molecule CD44v6 expression were investigated immunohistochemically to search their role in the metastasis and the clinical outcome of the patients with NSCLCs. Results: Twenty-three tumours (70%) were squamous cell carcinoma (SCC), 9 (27%) were adenocarcinoma (AC), and 1 (3%) was large cell carcinoma (LCC). MMP-2 and TIMP-2 were expressed in high rates in NSCLC but CD44v6 expression was about 50%. Lymphatic invasion was less frequent in TIMP-2-positive patients and this difference was statistically significant (P = 0.005). There was a statistically significant difference between SCCs and ACs with respect to CD44v6 tumoral expression (P = 0.004). Also, there was a negative correlation between lymphatic invasion and the extent of CD44v6; lymphatic invasion was significantly less in CD446-positive cases (P = 0.013). Conclusion: We found that TIMP-2 and CD44v6 can decrease the lymphatic invasion in NSCLCs. Also there was observed histiotype-related pattern of CD44v6 variant expression in SCCs.
Pericardial lipoma: An autopsy case and review of the literature
(Wiley, 2006-12-31) Durak, Dilek; Eren, Bülent; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0003-3469-340X; 0000-0002-8296-5484; 56700124800; 8725969000
Postmortem examination performed on a 70-year-old man revealed a thinly encapsulated, ovoid, large mass in the right hemithorax. The tumor was attached with its pedicle to the atrioventral pericardium and adjoined the diaphragm with compression of the right lower lobe of the lung. There was no adhesion between the tumor and the surrounding organs. Light microscopy showed a lipoma consisting of mature adipose tissue, and no malignancy was found.
Single ventricle cardiac defect
(Pakistan Medical Assoc, 2010-05) Şenel, Berna; Çetin, Volkan; Eren, Bülent; Türkmen, Nursel; Fedakar, Recep; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-8296-5484; AAK-8096-2021; AAH-6287-2021; 8725969000; 8715251700; 8725968900
Single ventricle heart is defined as a rare cardiac abnormality with a single ventricle chamber involving diverse functional and physiological defects. Our case is of a ten month-old baby boy who died shortly after admission to the hospital due to vomiting and diarrhoea. Autopsy findings revealed cyanosis of finger nails and ears. Internal examination revealed; large heart, weighing 60 grams, single ventricle, without a septum and upper membranous part. Single ventricle is a rare pathology, hence, this paper aims to discuss this case from a medico-legal point of view.
An unusual cause of sudden death: Cardiac myxoma
(Springer, 2007-05) Çomunoğlu, Nil; Türkmen, Nursel; Eren, Bülent; Fedakar, Recep; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-8296-5484; AAH-6287-2021; AAK-8096-2021; 8715251700; 8725969000; 8725968900
Primary tumors of the heart are rare; the most common cardiac tumor is atrial myxoma. Sudden death may occur in patients with atrial myxoma, tumor embolization, or obstruction of blood flow at the mitral or tricuspid valve. This report describes an unusual cause of sudden death and the autopsy findings for a 73-year-old man with left atrial myxoma.

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