Strong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriots

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dc.contributor.authorTuncel, Gülten
dc.contributor.authorErgören, Mahmut Çerkez
dc.contributor.buuauthorTemel, Şehime Gülsün
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Bölümü.tr_TR
dc.contributor.orcid0000-0002-9802-0880tr_TR
dc.contributor.researcheridAAG-8385-2021tr_TR
dc.contributor.scopusid6507885442tr_TR
dc.date.accessioned2023-10-16T08:30:14Z
dc.date.available2023-10-16T08:30:14Z
dc.date.issued2019-06
dc.description.abstractVitamin D is an important molecule to keep teeth, bones and muscles healthy. It is obtained from diet, supplements and primarily from exposure to sunlight. In recent years, vitamin D deficiency is recognised as a worldwide health problem, which results in disturbances in mineral metabolism and skeletal problems. Deficiency might be caused due to sedentary lifestyle, insufficient diet, age as well as some polymorphisms in the VDR gene. In this study the four most common VDR polymorphisms (rs1544410 (BsmI), rs731236 (TaqI), rs7975232 (ApaI) and rs2228570 (FokI)) are investigated in a cohort of Turkish Cypriots and aimed to detect any possible links between low serum vitamin D levels and these variants. The rs2228570 (FokI) variant but not others were shown to have a significant association with decreased serum vitamin D levels in the Turkish Cypriot population.en_US
dc.identifier.citationTuncel, G. (2019). "Strong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriots". 46(3), 3349-3355.en_US
dc.identifier.endpage3355tr_TR
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue3tr_TR
dc.identifier.pubmed30977086tr_TR
dc.identifier.scopus2-s2.0-85064245631tr_TR
dc.identifier.startpage3349tr_TR
dc.identifier.urihttps://doi.org/10.1007/s11033-019-04796-6
dc.identifier.urihttps://link.springer.com/article/10.1007/s11033-019-04796-6
dc.identifier.urihttp://hdl.handle.net/11452/34373
dc.identifier.volume46tr_TR
dc.identifier.wos000470332600072
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVDRen_US
dc.subjectPolymorphismen_US
dc.subjectVitamin D deficiencyen_US
dc.subjectCyprusen_US
dc.subjectD-receptor geneen_US
dc.subjectLow-back-painen_US
dc.subjectDiabetes-mellitusen_US
dc.subjectProstate-canceren_US
dc.subjectPolymorphismsen_US
dc.subjectRisken_US
dc.subjectSusceptibilityen_US
dc.subjectSystemen_US
dc.subjectAsthmaen_US
dc.subjectBSMIen_US
dc.subjectBiochemistry & Molecular Biologyen_US
dc.subject.emtreeVitamin Den_US
dc.subject.emtreeVitamin D receptoren_US
dc.subject.emtreeCalcitriol receptoren_US
dc.subject.emtreeVDR protein, humanen_US
dc.subject.emtreeAlleleen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCohort analysisen_US
dc.subject.emtreeCyprioten_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGene structureen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeGenetic linkageen_US
dc.subject.emtreeGenetic polymorphismen_US
dc.subject.emtreeGenetic variabilityen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeTurk (people)en_US
dc.subject.emtreeVDR geneen_US
dc.subject.emtreeVitamin blood levelen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeCase control studyen_US
dc.subject.emtreeCyprusen_US
dc.subject.emtreeEthnologyen_US
dc.subject.emtreeGene frequencyen_US
dc.subject.emtreeGenetic association studyen_US
dc.subject.emtreeGenetic predispositionen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeOdds ratioen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeSingle nucleotide polymorphismen_US
dc.subject.emtreeTurkey (bird)en_US
dc.subject.emtreeVitamin D deficiencyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshCyprusen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene frequencyen_US
dc.subject.meshGenetic association studiesen_US
dc.subject.meshGenetic predisposition to diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds ratioen_US
dc.subject.meshPolymorphismen_US
dc.subject.meshSingle nucleotideen_US
dc.subject.meshReceptors, calcitriolen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshTurkeyen_US
dc.subject.meshVitamin Den_US
dc.subject.meshVitamin D deficiencyen_US
dc.subject.scopusCalcitriol Receptors; 25-Hydroxyvitamin D; Breast Neoplasmsen_US
dc.subject.wosBiochemistry & Molecular Biologyen_US
dc.titleStrong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriotsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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