Can the outcome of autoaugmentation omentocystoplasty be improved? Urodynamic, histological, and collagen content evaluation in sheep model

Simple item page
dc.contributor.authorBurgu, Berk
dc.contributor.authorKeskin, Selçuk
dc.contributor.authorOrhan, Diclehan
dc.contributor.authorÖzgencil, Eser
dc.contributor.authorŞenel, Oytun
dc.contributor.authorAydoğdu, Özgü
dc.contributor.authorTekgül, Serdar
dc.contributor.buuauthorDoğan, Hasan Serkan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.tr_TR
dc.contributor.researcheridABH-5513-2020tr_TR
dc.contributor.scopusid7005856022tr_TR
dc.date.accessioned2022-03-28T07:50:47Z
dc.date.available2022-03-28T07:50:47Z
dc.date.issued2011
dc.description.abstractAim: To compare histological and urodynamic outcome of the classical detrusorotomy with and without the aid of intravesical balloon distension. We also describe a new technique with multiple detrusor incisions instead of detrusorotomy. Methods: A total of 24 animals were included in the study. Three different techniques of autoaugmentation cystoplasty were applied to surgically reduced bladders of 14 sheep. Five sheep underwent surgical reduction of bladder capacity as control group and five sheep underwent sham operation. In Group DIB (detrusor incision with balloon), standard whole thickness incisions on bladder wall were performed and a silicon balloon was inflated intravesically postoperatively. Group DMB (detrusorotomy with balloon) and Group DM (detrusorotomy) underwent standard detrusorotomy. After measuring capacities and compliances, animals were sacrificed on 90th postoperative day. Bladders were histopathologically evaluated. Expression of vascular endothelial growth factor (VEGF), CD31, and microvessel density (MVD) was noted. Quantification of collagen subtypes was also performed. Results: The mean capacity and compliance for Group DM and control were not significantly different and both were lower than other augmentation groups and sham. In Groups DMB and DM fibrosis was significantly increased. The VEGF expression was lower in Group DIB with respect to other augmentation groups whereas MVD was not significantly different. Measurement of total collagen and collagen subtypes revealed an increase in total collagen of groups DMB and DM when compared to other groups. Quantification of collagen subtypes demonstrated that types I and III were significantly increased in aforementioned groups. Conclusion: Autoaugmentation omentocystoplasty in sheep model does not result in a reliable increase in bladder capacity and compliance. Intravesical balloon inflation makes the achievement more pronounced and significantly increases the bladder capacity and compliance.en_US
dc.identifier.citationBurgu, B. vd. (2011). "Can the outcome of autoaugmentation omentocystoplasty be improved? Urodynamic, histological, and collagen content evaluation in sheep model". Neurourology and Urodynamics, 30(7), 1371-1375.en_US
dc.identifier.endpage1375tr_TR
dc.identifier.issn0733-2467
dc.identifier.issn1520-6777
dc.identifier.issue7tr_TR
dc.identifier.pubmed21404322tr_TR
dc.identifier.scopus2-s2.0-80052076755tr_TR
dc.identifier.startpage1371tr_TR
dc.identifier.urihttps://doi.org/10.1002/nau.21010
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/nau.21010
dc.identifier.urihttp://hdl.handle.net/11452/25373
dc.identifier.volume30tr_TR
dc.identifier.wos000294727800034tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalNeurourology and Urodynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrology & nephrologyen_US
dc.subjectAutoaugmentationen_US
dc.subjectCollagenen_US
dc.subjectIntavesical balloonen_US
dc.subjectSheepen_US
dc.subjectVascularizationen_US
dc.subjectBladder autoaugmentationen_US
dc.subjectAugmentationen_US
dc.subjectGastrocystoplastyen_US
dc.subjectUrotheliumen_US
dc.subject.emtreeCD31 antigenen_US
dc.subject.emtreeCollagenen_US
dc.subject.emtreeCollagen type 1en_US
dc.subject.emtreeCollagen type 3en_US
dc.subject.emtreeVasculotropinen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAutoaugmentation omentocystoplastyen_US
dc.subject.emtreeBalloon catheteren_US
dc.subject.emtreeBladder capacityen_US
dc.subject.emtreeBladder reconstructionen_US
dc.subject.emtreeContent analysisen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFibrosisen_US
dc.subject.emtreeHistologyen_US
dc.subject.emtreeMicrovasculatureen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeOmentoplastyen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeSham procedureen_US
dc.subject.emtreeSheepen_US
dc.subject.emtreeSurgical techniqueen_US
dc.subject.emtreeUrodynamicsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, CD31en_US
dc.subject.meshCollagenen_US
dc.subject.meshComplianceen_US
dc.subject.meshDilatationen_US
dc.subject.meshFemaleen_US
dc.subject.meshModels, animalen_US
dc.subject.meshOmentumen_US
dc.subject.meshSheepen_US
dc.subject.meshSurgical fapsen_US
dc.subject.meshTime factorsen_US
dc.subject.meshUrinary bladderen_US
dc.subject.meshUrodynamicsen_US
dc.subject.meshUrologic surgical proceduresen_US
dc.subject.meshVascular endothelial growth factor aen_US
dc.subject.scopusUrinary Diversion; Urethral Catheterization; Bladderen_US
dc.subject.wosUrology & nephrologyen_US
dc.titleCan the outcome of autoaugmentation omentocystoplasty be improved? Urodynamic, histological, and collagen content evaluation in sheep modelen_US
dc.typeArticle
dc.wos.quartileQ1en_US

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science
PubMed
Scopus