Open-label trial of cyclosporine for vulvar lichen sclerosus

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dc.contributor.buuauthorBaşkan, Emel Bülbül
dc.contributor.buuauthorTuran, Hakan
dc.contributor.buuauthorTunalı, Şükran
dc.contributor.buuauthorToker, Semra Çıkman
dc.contributor.buuauthorSarıcaoğlu, Hayriye
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabiilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0144-3263tr_TR
dc.contributor.researcheridAAH-1388-2021tr_TR
dc.contributor.scopusid6602518817tr_TR
dc.contributor.scopusid16835681500tr_TR
dc.contributor.scopusid7004191748tr_TR
dc.contributor.scopusid14054750900tr_TR
dc.contributor.scopusid6603722836tr_TR
dc.date.accessioned2022-10-24T08:59:59Z
dc.date.available2022-10-24T08:59:59Z
dc.date.issued2007-08
dc.description.abstractBackground: Lichen sclerosus (LS) is a chronic inflammatory disease of skin and mucosal surfaces which is generally difficult to treat. Objective: We evaluated the efficacy of oral cyclosporine in refractory vulvar LS. Methods: Five patients with refractory vulvar LS were treated with oral cyclosporine (3-4 mg/kg/d) for 3 months. They were followed up on a monthly basis. Results: At the end of the treatment, the mean total symptom score regressed significantly and clinical findings such as erythema and erosion showed marked improvement. Mild adverse effects were seen in 3 patients. Limitations: The patients did not give consent to rebiopsy at the end of the treatment. Conclusion: Moderate dose of oral cyclosporine could be an effective alternative in the treatment of refractory vulvar LS.en_US
dc.identifier.citationBaşkan, E. B. vd. (2007). "Open-label trial of cyclosporine for vulvar lichen sclerosus". Journal of the American Academy of Dermatology, 57(2), 276-278.en_US
dc.identifier.endpage278tr_TR
dc.identifier.issn0190-9622
dc.identifier.issue2tr_TR
dc.identifier.pubmed17442452tr_TR
dc.identifier.scopus2-s2.0-34447257389tr_TR
dc.identifier.startpage276tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.jaad.2007.03.006
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0190962207005403
dc.identifier.urihttp://hdl.handle.net/11452/29191
dc.identifier.volume57tr_TR
dc.identifier.wos000248340000011tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherMosby Elsevieren_US
dc.relation.journalJournal of the American Academy of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDermatologyen_US
dc.subjectClobetasolen_US
dc.subject.emtreePimecrolimusen_US
dc.subject.emtreeCalcipotriolen_US
dc.subject.emtreeClobetasolen_US
dc.subject.emtreeCyclosporinen_US
dc.subject.emtreeEstrogenen_US
dc.subject.emtreeTestosteroneen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeLichen sclerosus et atrophicusen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeDrug dose reductionen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeErosionen_US
dc.subject.emtreeErythemaen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFollow upen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeRemissionen_US
dc.subject.emtreeOutcome assessmenten_US
dc.subject.emtreeOpen studyen_US
dc.subject.emtreeRetrospective studyen_US
dc.subject.emtreeTreatment durationen_US
dc.subject.emtreeTreatment responseen_US
dc.subject.meshAdministration, oralen_US
dc.subject.meshFollow-up studiesen_US
dc.subject.meshAdministration, topicalen_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-inflammatory agentsen_US
dc.subject.meshClobetasolen_US
dc.subject.meshCyclosporineen_US
dc.subject.meshFemaleen_US
dc.subject.meshVulvar lichen sclerosusen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshOintmentsen_US
dc.subject.meshRetrospective studiesen_US
dc.subject.meshTreatment outcomeen_US
dc.subject.scopusLichen Sclerosus Et Atrophicus; Vulva Kraurosis; Balanitis Xerotica Obliteransen_US
dc.subject.wosDermatologyen_US
dc.titleOpen-label trial of cyclosporine for vulvar lichen sclerosusen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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