Acitretin-induced subungual hemorrhage

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dc.contributor.buuauthorAydoğan, Kenan
dc.contributor.buuauthorKaradoğan, Serap Köran
dc.contributor.buuauthorTunalı, Şükran
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0193-1128tr_TR
dc.contributor.scopusid9739755800tr_TR
dc.contributor.scopusid9738885800tr_TR
dc.contributor.scopusid7004191748tr_TR
dc.date.accessioned2023-02-27T07:54:51Z
dc.date.available2023-02-27T07:54:51Z
dc.date.issued2007-04-30
dc.descriptionBu çalışma, 12-16 Ekim 2005 tarihlerinde Londra[Birleşik Krallık]'da düzenlenen 14. Congress of The European Academy of Dermatology and Venereology'de poster olarak sunulmuştur.tr_TR
dc.description.abstractA 20-year-old woman with a 2-year history of histologically confirmed palmoplantar keratoderma due to psoriasis, resistant to several topical agents, was admitted to the Department of Dermatology, Uludag University, Bursa, Turkey. Therapy with oral acitretin (0.5mg/kg/day, 35mg/day) was initiated. A month after starting acitretin treatment, she noted slight reddening of the second left fingernail. Clinical examination revealed red-brown discoloration of the second fingernail associated with subungual hemorrhage involving the proximal nail bed (lunula region) (Fig. 1). The nail change was asymptomatic. The patient complained only of discoloration underneath the nail plate. No abnormalities were detected on the skin, mucous membranes, or toenails/ other fingernails. The patient denied exposure to microtrauma or any other drugs. The erythrocyte sedimentation rate, full blood cell count, electrolytes, renal and hepatic tests, and serum lipids were normal. Coagulation tests, including blood clotting time, international normalized ratio, activated partial thromboplastin time, thrombin time, platelet number, and function tests, were within normal levels. Treatment with acitretin was discontinued, and the nail change resolved completely after 3 weeks. A similar episode of subungual hemorrhage recurred, however, within 48 h after re-challenge with a lower dose of acitretin (25 mg/day). The drug was definitively stopped and the eruption faded again within a week. An objective causality assessment suggests that subungual hemorrhage was probably related to acitretin in this patient.en_US
dc.identifier.citationAydoğan, K. vd. (2007). "Acitretin-induced subungual hemorrhage". International Journal of Dermatology, 46(5), 494-495.en_US
dc.identifier.endpage495tr_TR
dc.identifier.issn0011-9059
dc.identifier.issue5tr_TR
dc.identifier.pubmed17472680tr_TR
dc.identifier.scopus2-s2.0-34248183569tr_TR
dc.identifier.startpage494tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1365-4632.2006.03059.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1365-4632.2006.03059.x
dc.identifier.urihttp://hdl.handle.net/11452/31220
dc.identifier.volume46tr_TR
dc.identifier.wos000246150900012tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDermatologyen_US
dc.subjectPsoriasisen_US
dc.subjectEtretinatemen_US
dc.subjectMulticenteren_US
dc.subjectSecondaryen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood cell counten_US
dc.subject.emtreeBlood clotting testen_US
dc.subject.emtreeBlood clotting timeen_US
dc.subject.emtreeCase reporten_US
dc.subject.emtreeClinical examinationen_US
dc.subject.emtreeDisease durationen_US
dc.subject.emtreeDrug withdrawalen_US
dc.subject.emtreeErythrocyte sedimentation rateen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHospital admissionen_US
dc.subject.emtreeHospital departmenten_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInternational normalized ratioen_US
dc.subject.emtreeKeratosis palmoplantarisen_US
dc.subject.emtreeKidney function testen_US
dc.subject.emtreeLipid blood levelen_US
dc.subject.emtreeLiver function testen_US
dc.subject.emtreeNail diseaseen_US
dc.subject.emtreePartial thromboplastin timeen_US
dc.subject.emtreePsoriasisen_US
dc.subject.emtreeThrombin timeen_US
dc.subject.emtreeThrombocyte counten_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeUniversity hospitalen_US
dc.subject.emtreeElectrolyteen_US
dc.subject.emtreeEtretinen_US
dc.subject.emtreeLipiden_US
dc.subject.meshAcitretinen_US
dc.subject.meshAdministration, oralen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshHemorrhageen_US
dc.subject.meshHumansen_US
dc.subject.meshKeratoderma, palmoplantaren_US
dc.subject.meshKeratolytic agentsen_US
dc.subject.meshNail diseasesen_US
dc.subject.scopusPhototherapy; Pustulosis Palmoplantaris; Etretinen_US
dc.subject.wosDermatologyen_US
dc.titleAcitretin-induced subungual hemorrhageen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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